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- W2901479719 abstract "New isatin-β-thiocarbohydrazone hybrids 4-17 were designed relied on isatin scaffold to generate various analogs with expected antimicrobial activity. The new hybrids were estimated for antibacterial effectiveness over S. aureus, B. cereus and E. coli, and antifungal efficacy over C. albicans and A. fumigatus. Compound 14 evinced the highest efficacy over A. fumigatus and C. albicans. In addition, 5 and 12 showed eminent efficacy toward A. fumigatus, where compounds 4, 7, 9, 11, 13, 15 and 16 exhibited moderate activity over the same fungus. Moreover, 6 and 9 displayed moderate activity over C. albicans. The new compounds were also estimated for antiquorum-sensing effectiveness against C. violacium, where compound 17 showed interesting activity. In vitro cytotoxicity assay of the new analogs was done over Hela and COS-7 cancer cell lines. All analogs have IC50 values >50 μM toward both cell lines." @default.
- W2901479719 created "2018-11-29" @default.
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- W2901479719 date "2018-11-17" @default.
- W2901479719 modified "2023-10-18" @default.
- W2901479719 title "Microwave-assisted synthesis, antimicrobial, antiquorum-sensing and cytotoxic activities of a new series of isatin-β-thiocarbohydrazones" @default.
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- W2901479719 doi "https://doi.org/10.1080/00397911.2018.1520889" @default.
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