Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901492711> ?p ?o ?g. }
- W2901492711 endingPage "2111" @default.
- W2901492711 startingPage "2103" @default.
- W2901492711 abstract "Cells of all mammals recognize double-stranded RNA (dsRNA) as a foreign material. In response, they release interferons (IFNs) and activate a ubiquitously expressed pseudokinase/endoribonuclease RNase L. RNase L executes regulated RNA decay and halts global translation. Here, we developed a biosensor for 2',5'-oligoadenylate (2-5A), the natural activator of RNase L. Using this biosensor, we found that 2-5A was acutely synthesized by cells in response to dsRNA sensing, which immediately triggered cellular RNA cleavage by RNase L and arrested host protein synthesis. However, translation-arrested cells still transcribed IFN-stimulated genes and secreted IFNs of types I and III (IFN-β and IFN-λ). Our data suggest that IFNs escape from the action of RNase L on translation. We propose that the 2-5A/RNase L pathway serves to rapidly and accurately suppress basal protein synthesis, preserving privileged production of defense proteins of the innate immune system." @default.
- W2901492711 created "2018-11-29" @default.
- W2901492711 creator A5010804800 @default.
- W2901492711 creator A5023199603 @default.
- W2901492711 creator A5026315981 @default.
- W2901492711 creator A5030517401 @default.
- W2901492711 creator A5054538286 @default.
- W2901492711 creator A5061877057 @default.
- W2901492711 creator A5070124654 @default.
- W2901492711 creator A5071133192 @default.
- W2901492711 creator A5080021282 @default.
- W2901492711 creator A5080123162 @default.
- W2901492711 date "2019-01-17" @default.
- W2901492711 modified "2023-10-18" @default.
- W2901492711 title "Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L" @default.
- W2901492711 cites W1516930947 @default.
- W2901492711 cites W1519427152 @default.
- W2901492711 cites W1550721230 @default.
- W2901492711 cites W1866441788 @default.
- W2901492711 cites W1967390196 @default.
- W2901492711 cites W1969119726 @default.
- W2901492711 cites W1972683642 @default.
- W2901492711 cites W1978064890 @default.
- W2901492711 cites W1980396381 @default.
- W2901492711 cites W1980438612 @default.
- W2901492711 cites W1995296637 @default.
- W2901492711 cites W1999087217 @default.
- W2901492711 cites W2001951173 @default.
- W2901492711 cites W2010532053 @default.
- W2901492711 cites W2024701689 @default.
- W2901492711 cites W2037513168 @default.
- W2901492711 cites W2040640278 @default.
- W2901492711 cites W2046013214 @default.
- W2901492711 cites W2060421066 @default.
- W2901492711 cites W2061742276 @default.
- W2901492711 cites W2078870286 @default.
- W2901492711 cites W2083693608 @default.
- W2901492711 cites W2085552343 @default.
- W2901492711 cites W2086931364 @default.
- W2901492711 cites W2087670757 @default.
- W2901492711 cites W2091523299 @default.
- W2901492711 cites W2094191346 @default.
- W2901492711 cites W2098624952 @default.
- W2901492711 cites W2099963467 @default.
- W2901492711 cites W2101083359 @default.
- W2901492711 cites W2102050179 @default.
- W2901492711 cites W2122877775 @default.
- W2901492711 cites W2122994357 @default.
- W2901492711 cites W2138262758 @default.
- W2901492711 cites W2143542499 @default.
- W2901492711 cites W2149444093 @default.
- W2901492711 cites W2157135427 @default.
- W2901492711 cites W2162711679 @default.
- W2901492711 cites W2165094405 @default.
- W2901492711 cites W2166343003 @default.
- W2901492711 cites W2175514210 @default.
- W2901492711 cites W2207109000 @default.
- W2901492711 cites W2231530063 @default.
- W2901492711 cites W2255242978 @default.
- W2901492711 cites W2263177460 @default.
- W2901492711 cites W2345499595 @default.
- W2901492711 cites W2559845696 @default.
- W2901492711 cites W2600241225 @default.
- W2901492711 cites W2604527570 @default.
- W2901492711 cites W2747389445 @default.
- W2901492711 cites W2766528155 @default.
- W2901492711 cites W2767888279 @default.
- W2901492711 cites W303679952 @default.
- W2901492711 doi "https://doi.org/10.1073/pnas.1818363116" @default.
- W2901492711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6369740" @default.
- W2901492711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30655338" @default.
- W2901492711 hasPublicationYear "2019" @default.
- W2901492711 type Work @default.
- W2901492711 sameAs 2901492711 @default.
- W2901492711 citedByCount "27" @default.
- W2901492711 countsByYear W29014927112019 @default.
- W2901492711 countsByYear W29014927112020 @default.
- W2901492711 countsByYear W29014927112021 @default.
- W2901492711 countsByYear W29014927112022 @default.
- W2901492711 countsByYear W29014927112023 @default.
- W2901492711 crossrefType "journal-article" @default.
- W2901492711 hasAuthorship W2901492711A5010804800 @default.
- W2901492711 hasAuthorship W2901492711A5023199603 @default.
- W2901492711 hasAuthorship W2901492711A5026315981 @default.
- W2901492711 hasAuthorship W2901492711A5030517401 @default.
- W2901492711 hasAuthorship W2901492711A5054538286 @default.
- W2901492711 hasAuthorship W2901492711A5061877057 @default.
- W2901492711 hasAuthorship W2901492711A5070124654 @default.
- W2901492711 hasAuthorship W2901492711A5071133192 @default.
- W2901492711 hasAuthorship W2901492711A5080021282 @default.
- W2901492711 hasAuthorship W2901492711A5080123162 @default.
- W2901492711 hasBestOaLocation W29014927111 @default.
- W2901492711 hasConcept C104317684 @default.
- W2901492711 hasConcept C105580179 @default.
- W2901492711 hasConcept C10879258 @default.
- W2901492711 hasConcept C149364088 @default.
- W2901492711 hasConcept C153911025 @default.
- W2901492711 hasConcept C159047783 @default.