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• W2901493218 abstract "Abstract Hemodialysis for chronic renal failure was introduced and developed in Seattle, WA, in the 1960s. Using Kiil dialyzers, weekly dialysis time and frequency were established to be about 30 hours on 3 time weekly dialysis. This dialysis time and frequency was associated with 10% yearly mortality in the United States in 1970s. Later in 1970s, newer and more efficient dialyzers were developed and it was felt that dialysis time could be shortened. An additional incentive to shorten dialysis was felt to be lower cost and higher convenience. Additional support for shortening dialysis time was provided by a randomized prospective trial performed by National Cooperative Dialysis Study (NCDS). This study committed a Type II statistical error rejecting the time of dialysis as an important factor in determining the quality of dialysis. This study also provided the basis for the establishment of the Kt/V urea index as a measure of dialysis adequacy. This index having been established in a sacrosanct randomized controlled trial (RCT), was readily accepted by the HD community, and led to shorter dialysis, and higher mortality in the United States. Kt/V urea is a poor measure of dialysis quality because it combines three unrelated variables into a single formula. These variables influence the clinical status of the patient independent of each other. It is impossible to compensate short dialysis duration (t) with the increased clearance of urea (K), because the tolerance of ultrafiltration depends on the plasma‐refilling rate, which has nothing in common with urea clearance. Later, another RCT (the HEMO study) committed a Type III statistical error by asking the wrong research question, thus not yielding any valuable results. Fortunately, it did not lead to deterioration of dialysis outcomes in the United States. The third RCT in this field (“in‐center hemodialysis 6 times per week versus 3 times per week”) did not bring forth any valuable results, but at least confirmed what was already known. The fourth such trial (“The effects of frequent nocturnal home hemodialysis”) too did not show any positive results primarily due to significant subject recruitment issues leading to inappropriate selection of patients. Comparison of the value of peritoneal dialysis and HD in RCTs could not be completed because of recruitment problems. Randomized controlled trials have therefore failed to yield any meaningful information in the area of dose and or frequency of hemodialysis." @default.
• W2901493218 created "2018-11-29" @default.
• W2901493218 creator A5070111035 @default.
• W2901493218 creator A5078896108 @default.
• W2901493218 date "2018-10-01" @default.
• W2901493218 modified "2023-10-04" @default.
• W2901493218 title "A need for a paradigm shift in focus: From Kt/V_ureato appropriate removal of sodium (the ignored uremic toxin)" @default.
• W2901493218 cites W119772017 @default.
• W2901493218 cites W1585898998 @default.
• W2901493218 cites W1589468757 @default.
• W2901493218 cites W1591736691 @default.
• W2901493218 cites W190842063 @default.
• W2901493218 cites W1964826356 @default.
• W2901493218 cites W1965654099 @default.
• W2901493218 cites W1966360818 @default.
• W2901493218 cites W1968466300 @default.
• W2901493218 cites W1971338572 @default.
• W2901493218 cites W1972712321 @default.
• W2901493218 cites W1973969311 @default.
• W2901493218 cites W1981222637 @default.
• W2901493218 cites W1982036702 @default.
• W2901493218 cites W1982203662 @default.
• W2901493218 cites W1983685868 @default.
• W2901493218 cites W1985737499 @default.
• W2901493218 cites W1988247085 @default.
• W2901493218 cites W1994119233 @default.
• W2901493218 cites W1996458600 @default.
• W2901493218 cites W1997458494 @default.
• W2901493218 cites W1998637589 @default.
• W2901493218 cites W2000275644 @default.
• W2901493218 cites W2005117301 @default.
• W2901493218 cites W2009827993 @default.
• W2901493218 cites W2013220681 @default.
• W2901493218 cites W2015414294 @default.
• W2901493218 cites W2019837788 @default.
• W2901493218 cites W2020400938 @default.
• W2901493218 cites W2021164080 @default.
• W2901493218 cites W2022320644 @default.
• W2901493218 cites W2023144747 @default.
• W2901493218 cites W2024178248 @default.
• W2901493218 cites W2033172489 @default.
• W2901493218 cites W2035063106 @default.
• W2901493218 cites W2035373592 @default.
• W2901493218 cites W2038570295 @default.
• W2901493218 cites W2039354600 @default.
• W2901493218 cites W2040777756 @default.
• W2901493218 cites W2043110900 @default.
• W2901493218 cites W2044365682 @default.
• W2901493218 cites W2046133290 @default.
• W2901493218 cites W2046934161 @default.
• W2901493218 cites W2048325364 @default.
• W2901493218 cites W2050035272 @default.
• W2901493218 cites W2052823058 @default.
• W2901493218 cites W2054361787 @default.
• W2901493218 cites W2059388576 @default.
• W2901493218 cites W2063527500 @default.
• W2901493218 cites W2067595465 @default.
• W2901493218 cites W2068772557 @default.
• W2901493218 cites W2069280895 @default.
• W2901493218 cites W2070309439 @default.
• W2901493218 cites W2074383190 @default.
• W2901493218 cites W2075651763 @default.
• W2901493218 cites W2076955620 @default.
• W2901493218 cites W2078686645 @default.
• W2901493218 cites W2084775027 @default.
• W2901493218 cites W2085183224 @default.
• W2901493218 cites W2086154367 @default.
• W2901493218 cites W2087724260 @default.
• W2901493218 cites W2090759999 @default.
• W2901493218 cites W2091809632 @default.
• W2901493218 cites W2092967724 @default.
• W2901493218 cites W2093483948 @default.
• W2901493218 cites W2098071664 @default.
• W2901493218 cites W2102324358 @default.
• W2901493218 cites W2105322673 @default.
• W2901493218 cites W2112488843 @default.
• W2901493218 cites W2113848844 @default.
• W2901493218 cites W2114693066 @default.
• W2901493218 cites W2115793908 @default.
• W2901493218 cites W2118291100 @default.
• W2901493218 cites W2120376107 @default.
• W2901493218 cites W2123493410 @default.
• W2901493218 cites W2129616197 @default.
• W2901493218 cites W2130329266 @default.
• W2901493218 cites W2135609266 @default.
• W2901493218 cites W2135732621 @default.
• W2901493218 cites W2137938257 @default.
• W2901493218 cites W2139219118 @default.
• W2901493218 cites W2141445133 @default.
• W2901493218 cites W2146023168 @default.
• W2901493218 cites W2149405263 @default.
• W2901493218 cites W2149448546 @default.
• W2901493218 cites W2153566321 @default.
• W2901493218 cites W2157507874 @default.
• W2901493218 cites W2164705482 @default.
• W2901493218 cites W2169000978 @default.
• W2901493218 cites W2170460897 @default.
• W2901493218 cites W2181782128 @default.
• W2901493218 cites W2181836982 @default.
• W2901493218 cites W2235267645 @default.

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