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• W2901493932 abstract "Abstract RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation and disease. Their binding sites cover more of the genome than coding exons; nevertheless, most noncoding variant-prioritization methods only focus on transcriptional regulation. Here, we integrate the portfolio of ENCODE-RBP experiments to develop RADAR, a variant-scoring framework. RADAR uses conservation, RNA structure, network centrality, and motifs to provide an overall impact score. Then it further incorporates tissue-specific inputs to highlight disease-specific variants. Our results demonstrate RADAR can successfully pinpoint variants, both somatic and germline, associated with RBP-function dysregulation, that cannot be found by most current prioritization methods, for example variants affecting splicing." @default.
• W2901493932 created "2018-11-29" @default.
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• W2901493932 date "2018-11-19" @default.
• W2901493932 modified "2023-09-24" @default.
• W2901493932 title "RADAR: annotation and prioritization of variants in the post-transcriptional regulome of RNA-binding proteins" @default.
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• W2901493932 doi "https://doi.org/10.1101/474072" @default.
• W2901493932 hasPublicationYear "2018" @default.
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