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- W2901502060 abstract "Severe malaria and viral infections cause life-threatening diseases in millions of people worldwide every year. In search for effective bioactive hybrid molecules, which may possess improved properties compared to their parent compounds, a series of betulinic acid/betulin based dimer and hybrid compounds carrying ferrocene and/or artesunic acid moieties, was designed and, synthesized de novo. Furthermore, they were analyzed in vitro against malaria parasites (growth inhibition of 3D7-strain P. falciparum-infected erythrocytes) and human cytomegalovirus (HCMV). From this series of hybrids/dimers, the betulinic acid/betulin and artesunic acid hybrids 11 and 12 showed the most potent activities against P. falciparum and HCMV. On the strength of results, additive and/or synergistic effects between the natural or semisynthetic products, such as betulinic acid-/betulin- and artesunic acid-derived compounds, are suggested on the basis of putatively complex modes of antimicrobial action. This advantage may be taken into account in future drug development." @default.
- W2901502060 created "2018-11-29" @default.
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- W2901502060 date "2019-01-01" @default.
- W2901502060 modified "2023-10-03" @default.
- W2901502060 title "Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities" @default.
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- W2901502060 doi "https://doi.org/10.1016/j.bmc.2018.11.018" @default.
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