FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901505320> ?p ?o ?g. }

• W2901505320 endingPage "3730" @default.
• W2901505320 startingPage "3730" @default.
• W2901505320 abstract "Effective therapies for erectile dysfunction (ED) associated with diabetes mellitus (DM) are needed. In this study, the effects of stromal cell-derived factor-1 (SDF-1)-expressing engineered mesenchymal stem cells (SDF-1 eMSCs) and the relevant mechanisms in the corpus cavernosum of a streptozotocin (STZ)-induced DM ED rat model were evaluated. In a randomized controlled trial, Sprague–Dawley (SD) rats (n = 48) were divided into four groups (n = 12/group): Normal (control), DM ED (diabetes induced by STZ), DM ED + BM-MSC (treated with bone marrow [BM]-derived MSCs), and DM ED + SDF-1 eMSC (treated with SDF-1-expressing BM-MSCs). After four weeks, intracavernosal pressure (ICP), an indicator of erectile function, was 0.75 ± 0.07 in the normal group, 0.27 ± 0.08 in the DM ED group, 0.42 ± 0.11 in the DM ED + BM-MSC group, and 0.58 ± 0.11 in the DM ED + SDF-1 eMSC group. BM-MSCs, especially SDF-1 eMSCs, improved ED (p < 0.05). SDF-1 eMSC treatment improved the smooth muscle content in the corpus cavernosum (p < 0.05). As SDF-1 expression increased, ED recovery improved. In the SDF-1 eMSC group, levels of neuronal nitric oxide synthase (nNOS) and phosphorylated endothelial NOS (p-eNOS) were higher than those in other groups (p < 0.05). In addition, high stromal cell-derived factor-1 (SDF-1) expression was associated with increased vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in DM ED rats (p < 0.05). Higher levels of phosphorylated protein kinase B (p-AKT)/protein kinase B (AKT) (p < 0.05) and B-cell lymphoma-2 (Bcl-2) and lower levels of the apoptosis factors Bcl2-associated x (Bax) and caspase-3 were observed in the MSC-treated group than in the DM ED group (p < 0.05). SDF-1 eMSCs showed beneficial effects on recovery from erectile function." @default.
• W2901505320 created "2018-11-29" @default.
• W2901505320 creator A5030517224 @default.
• W2901505320 creator A5039826308 @default.
• W2901505320 creator A5044728581 @default.
• W2901505320 creator A5045915712 @default.
• W2901505320 creator A5052742153 @default.
• W2901505320 creator A5058978154 @default.
• W2901505320 creator A5063822726 @default.
• W2901505320 creator A5064706570 @default.
• W2901505320 creator A5064750279 @default.
• W2901505320 creator A5065311878 @default.
• W2901505320 creator A5070299337 @default.
• W2901505320 creator A5075307711 @default.
• W2901505320 creator A5078381046 @default.
• W2901505320 creator A5090332742 @default.
• W2901505320 date "2018-11-23" @default.
• W2901505320 modified "2023-10-14" @default.
• W2901505320 title "Engineered Mesenchymal Stem Cells Expressing Stromal Cell-derived Factor-1 Improve Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats" @default.
• W2901505320 cites W1660259488 @default.
• W2901505320 cites W1882775097 @default.
• W2901505320 cites W1892364723 @default.
• W2901505320 cites W1966530219 @default.
• W2901505320 cites W1979043688 @default.
• W2901505320 cites W1987520122 @default.
• W2901505320 cites W1990253071 @default.
• W2901505320 cites W2000973677 @default.
• W2901505320 cites W2003698942 @default.
• W2901505320 cites W2026090536 @default.
• W2901505320 cites W2037589198 @default.
• W2901505320 cites W2062907730 @default.
• W2901505320 cites W2063891798 @default.
• W2901505320 cites W2080559907 @default.
• W2901505320 cites W2085025583 @default.
• W2901505320 cites W2094518579 @default.
• W2901505320 cites W2097391898 @default.
• W2901505320 cites W2108875285 @default.
• W2901505320 cites W2115115786 @default.
• W2901505320 cites W2118701732 @default.
• W2901505320 cites W2138946470 @default.
• W2901505320 cites W2142298248 @default.
• W2901505320 cites W2145023494 @default.
• W2901505320 cites W2149285411 @default.
• W2901505320 cites W2159911604 @default.
• W2901505320 cites W2164329646 @default.
• W2901505320 cites W2168369822 @default.
• W2901505320 cites W2174795622 @default.
• W2901505320 cites W2182948109 @default.
• W2901505320 cites W2212034679 @default.
• W2901505320 cites W2331159203 @default.
• W2901505320 cites W2344013087 @default.
• W2901505320 cites W2550915777 @default.
• W2901505320 cites W2563459440 @default.
• W2901505320 cites W2606356811 @default.
• W2901505320 cites W2624110828 @default.
• W2901505320 cites W2736573284 @default.
• W2901505320 cites W2749855134 @default.
• W2901505320 cites W2753934688 @default.
• W2901505320 cites W2757023605 @default.
• W2901505320 cites W2805235251 @default.
• W2901505320 cites W2927569964 @default.
• W2901505320 doi "https://doi.org/10.3390/ijms19123730" @default.
• W2901505320 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6321323" @default.
• W2901505320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30477146" @default.
• W2901505320 hasPublicationYear "2018" @default.
• W2901505320 type Work @default.
• W2901505320 sameAs 2901505320 @default.
• W2901505320 citedByCount "30" @default.
• W2901505320 countsByYear W29015053202019 @default.
• W2901505320 countsByYear W29015053202020 @default.
• W2901505320 countsByYear W29015053202021 @default.
• W2901505320 countsByYear W29015053202022 @default.
• W2901505320 countsByYear W29015053202023 @default.
• W2901505320 crossrefType "journal-article" @default.
• W2901505320 hasAuthorship W2901505320A5030517224 @default.
• W2901505320 hasAuthorship W2901505320A5039826308 @default.
• W2901505320 hasAuthorship W2901505320A5044728581 @default.
• W2901505320 hasAuthorship W2901505320A5045915712 @default.
• W2901505320 hasAuthorship W2901505320A5052742153 @default.
• W2901505320 hasAuthorship W2901505320A5058978154 @default.
• W2901505320 hasAuthorship W2901505320A5063822726 @default.
• W2901505320 hasAuthorship W2901505320A5064706570 @default.
• W2901505320 hasAuthorship W2901505320A5064750279 @default.
• W2901505320 hasAuthorship W2901505320A5065311878 @default.
• W2901505320 hasAuthorship W2901505320A5070299337 @default.
• W2901505320 hasAuthorship W2901505320A5075307711 @default.
• W2901505320 hasAuthorship W2901505320A5078381046 @default.
• W2901505320 hasAuthorship W2901505320A5090332742 @default.
• W2901505320 hasBestOaLocation W29015053201 @default.
• W2901505320 hasConcept C126322002 @default.
• W2901505320 hasConcept C134018914 @default.
• W2901505320 hasConcept C142724271 @default.
• W2901505320 hasConcept C167734588 @default.
• W2901505320 hasConcept C16930146 @default.
• W2901505320 hasConcept C170493617 @default.
• W2901505320 hasConcept C198826908 @default.
• W2901505320 hasConcept C2775960820 @default.
• W2901505320 hasConcept C2777025900 @default.

• next