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• W2901506611 abstract "Research and design of drugs for treatment against microbial infections require the study of pathogenic proteins involved during infection and replication. Drugs can be designed to interfere with the interaction network of these pathogenic proteins and inhibit the infection process. Determination of the structure and ligands of the target proteins in microbes is essential for designing mechanistic-based drugs. Two Chlamydia proteins involved in host cell invasion were investigated in this study. The goal is to identify amino acids involved at the binding interface of Chlamydia chaperon proteins Scc1 and Scc4 by solution NMR spectroscopy. This information will give a lead in designing drugs that will interfere with Scc1:Scc4 binding, thus preventing Chlamydia invasion. Two new purification methods for isolating untagged Scc4 and the formation of mixed heterodimer complexes for NMR studies are described. The experimental NMR spectroscopy data was recorded and used to analyze the structural conformations of Scc4 when transitioning from homodimer to the heterodimer complex. Research presented in the second section is a novel structural modification method for therapeutic peptides through glycoalkylation. The modification is intended to improve the pharmacokinetic properties of lysine-containing peptide drugs, through half-life elongation and increased oral bioavailability. Specifically, the therapeutic tripeptide, Ac‑KPV-NH2, was modified with a sugar derivative. Although the effect of the modification could not be assessed through antimicrobial and anti-inflammatory tests, the glycoalkylated peptides are shown to be stable against pronase cleavage. The unmodified tripeptide was cleaved by pronase in less than 24 hours, indicating that the glycoalkylation confers proteolytic stability." @default.
• W2901506611 created "2018-11-29" @default.
• W2901506611 creator A5034473420 @default.
• W2901506611 date "2022-06-10" @default.
• W2901506611 modified "2023-10-15" @default.
• W2901506611 title "NMR Structural Investigation of Chlamydial Protein Complex and Lysine Glycomimetic for Drug Design" @default.
• W2901506611 cites W137428939 @default.
• W2901506611 cites W1527888204 @default.
• W2901506611 cites W1534250034 @default.
• W2901506611 cites W1544453555 @default.
• W2901506611 cites W1588679159 @default.
• W2901506611 cites W159622809 @default.
• W2901506611 cites W159772091 @default.
• W2901506611 cites W1691012859 @default.
• W2901506611 cites W1827384741 @default.
• W2901506611 cites W1856146536 @default.
• W2901506611 cites W1860382351 @default.
• W2901506611 cites W1876945793 @default.
• W2901506611 cites W1964164586 @default.
• W2901506611 cites W1965334549 @default.
• W2901506611 cites W1971169066 @default.
• W2901506611 cites W1971652191 @default.
• W2901506611 cites W1972234611 @default.
• W2901506611 cites W1972584860 @default.
• W2901506611 cites W1978666883 @default.
• W2901506611 cites W1980444234 @default.
• W2901506611 cites W1980535563 @default.
• W2901506611 cites W1980945213 @default.
• W2901506611 cites W1983131914 @default.
• W2901506611 cites W1986216396 @default.
• W2901506611 cites W1992450378 @default.
• W2901506611 cites W1995381722 @default.
• W2901506611 cites W1996284070 @default.
• W2901506611 cites W1997768835 @default.
• W2901506611 cites W1998222399 @default.
• W2901506611 cites W1998341792 @default.
• W2901506611 cites W2008518614 @default.
• W2901506611 cites W2011284512 @default.
• W2901506611 cites W2011393854 @default.
• W2901506611 cites W2012506141 @default.
• W2901506611 cites W2012634417 @default.
• W2901506611 cites W2012840643 @default.
• W2901506611 cites W2019790788 @default.
• W2901506611 cites W2027743942 @default.
• W2901506611 cites W2031918462 @default.
• W2901506611 cites W2033075555 @default.
• W2901506611 cites W2034758664 @default.
• W2901506611 cites W2034969165 @default.
• W2901506611 cites W2036511353 @default.
• W2901506611 cites W2036601571 @default.
• W2901506611 cites W2036919132 @default.
• W2901506611 cites W2041655580 @default.
• W2901506611 cites W2042639841 @default.
• W2901506611 cites W2043736572 @default.
• W2901506611 cites W2044199954 @default.
• W2901506611 cites W2044573804 @default.
• W2901506611 cites W2045248788 @default.
• W2901506611 cites W2047710091 @default.
• W2901506611 cites W2049322319 @default.
• W2901506611 cites W2050000500 @default.
• W2901506611 cites W2050811727 @default.
• W2901506611 cites W2052385946 @default.
• W2901506611 cites W2053988575 @default.
• W2901506611 cites W2054747491 @default.
• W2901506611 cites W2059832664 @default.
• W2901506611 cites W2060831509 @default.
• W2901506611 cites W2061998708 @default.
• W2901506611 cites W2070027483 @default.
• W2901506611 cites W2073047768 @default.
• W2901506611 cites W2074770586 @default.
• W2901506611 cites W2075470662 @default.
• W2901506611 cites W2075519217 @default.
• W2901506611 cites W2075819111 @default.
• W2901506611 cites W2076985673 @default.
• W2901506611 cites W2081172289 @default.
• W2901506611 cites W2081306620 @default.
• W2901506611 cites W2081837827 @default.
• W2901506611 cites W2084310228 @default.
• W2901506611 cites W2084845164 @default.
• W2901506611 cites W2087214422 @default.
• W2901506611 cites W2091579515 @default.
• W2901506611 cites W2092278008 @default.
• W2901506611 cites W2092771417 @default.
• W2901506611 cites W2093700493 @default.
• W2901506611 cites W2093974041 @default.
• W2901506611 cites W2094766468 @default.
• W2901506611 cites W2098225921 @default.
• W2901506611 cites W2098289636 @default.
• W2901506611 cites W2098838427 @default.
• W2901506611 cites W2103548696 @default.
• W2901506611 cites W2106877484 @default.
• W2901506611 cites W2107239395 @default.
• W2901506611 cites W2108845389 @default.
• W2901506611 cites W2109550123 @default.
• W2901506611 cites W2109877611 @default.
• W2901506611 cites W2109939279 @default.
• W2901506611 cites W2116380446 @default.
• W2901506611 cites W2121766101 @default.
• W2901506611 cites W2126020648 @default.
• W2901506611 cites W2127113854 @default.

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