FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901533991> ?p ?o ?g. }

• W2901533991 abstract "Abstract Designer receptors exclusively activated by designer drugs (DREADDs) derived from muscarinic receptors are a powerful tool to test causality in basic neuroscience, but are also potentially amenable to clinical translation. A major obstacle is however that the widely-used agonist clozapine-N-oxide undergoes conversion to clozapine, which penetrates the blood-brain barrier but has an unfavorable side effect profile. Perlapine has been reported to activate DREADDs at nanomolar concentrations, but is not approved for use in humans by the Food and Drug Administration or European Medicines Agency, limiting its translational potential. Here we report that the atypical antipsychotic drug olanzapine, widely available in various formulations, is a full and potent agonist of the human muscarinic-receptor M4-based DREADD, facilitating clinical translation of chemogenetics to treat CNS diseases." @default.
• W2901533991 created "2018-11-29" @default.
• W2901533991 creator A5007163256 @default.
• W2901533991 creator A5016825496 @default.
• W2901533991 creator A5018218680 @default.
• W2901533991 creator A5021821796 @default.
• W2901533991 creator A5039047464 @default.
• W2901533991 creator A5047142056 @default.
• W2901533991 creator A5055426888 @default.
• W2901533991 creator A5058837835 @default.
• W2901533991 creator A5080990266 @default.
• W2901533991 date "2018-11-24" @default.
• W2901533991 modified "2023-10-18" @default.
• W2901533991 title "Olanzapine: a full and potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics" @default.
• W2901533991 cites W1663154925 @default.
• W2901533991 cites W1735892282 @default.
• W2901533991 cites W1966403223 @default.
• W2901533991 cites W1976646460 @default.
• W2901533991 cites W1985517071 @default.
• W2901533991 cites W1987930903 @default.
• W2901533991 cites W1989820875 @default.
• W2901533991 cites W2001522991 @default.
• W2901533991 cites W2016460935 @default.
• W2901533991 cites W2027065525 @default.
• W2901533991 cites W2044851644 @default.
• W2901533991 cites W2074852398 @default.
• W2901533991 cites W2078374001 @default.
• W2901533991 cites W2088335517 @default.
• W2901533991 cites W2089242580 @default.
• W2901533991 cites W2103959703 @default.
• W2901533991 cites W2122995608 @default.
• W2901533991 cites W2133776757 @default.
• W2901533991 cites W2134079336 @default.
• W2901533991 cites W2155478691 @default.
• W2901533991 cites W2275148408 @default.
• W2901533991 cites W238238306 @default.
• W2901533991 cites W2409829112 @default.
• W2901533991 cites W2469411888 @default.
• W2901533991 cites W2726666234 @default.
• W2901533991 cites W2745223669 @default.
• W2901533991 cites W2767074493 @default.
• W2901533991 cites W2767891136 @default.
• W2901533991 cites W2804376135 @default.
• W2901533991 cites W2873849039 @default.
• W2901533991 cites W2883679687 @default.
• W2901533991 doi "https://doi.org/10.1101/477513" @default.
• W2901533991 hasPublicationYear "2018" @default.
• W2901533991 type Work @default.
• W2901533991 sameAs 2901533991 @default.
• W2901533991 citedByCount "2" @default.
• W2901533991 countsByYear W29015339912019 @default.
• W2901533991 countsByYear W29015339912020 @default.
• W2901533991 crossrefType "posted-content" @default.
• W2901533991 hasAuthorship W2901533991A5007163256 @default.
• W2901533991 hasAuthorship W2901533991A5016825496 @default.
• W2901533991 hasAuthorship W2901533991A5018218680 @default.
• W2901533991 hasAuthorship W2901533991A5021821796 @default.
• W2901533991 hasAuthorship W2901533991A5039047464 @default.
• W2901533991 hasAuthorship W2901533991A5047142056 @default.
• W2901533991 hasAuthorship W2901533991A5055426888 @default.
• W2901533991 hasAuthorship W2901533991A5058837835 @default.
• W2901533991 hasAuthorship W2901533991A5080990266 @default.
• W2901533991 hasBestOaLocation W29015339911 @default.
• W2901533991 hasConcept C118552586 @default.
• W2901533991 hasConcept C126322002 @default.
• W2901533991 hasConcept C15744967 @default.
• W2901533991 hasConcept C169760540 @default.
• W2901533991 hasConcept C170493617 @default.
• W2901533991 hasConcept C2776412080 @default.
• W2901533991 hasConcept C2776619155 @default.
• W2901533991 hasConcept C2778938600 @default.
• W2901533991 hasConcept C2780494398 @default.
• W2901533991 hasConcept C33789571 @default.
• W2901533991 hasConcept C71924100 @default.
• W2901533991 hasConcept C98274493 @default.
• W2901533991 hasConceptScore W2901533991C118552586 @default.
• W2901533991 hasConceptScore W2901533991C126322002 @default.
• W2901533991 hasConceptScore W2901533991C15744967 @default.
• W2901533991 hasConceptScore W2901533991C169760540 @default.
• W2901533991 hasConceptScore W2901533991C170493617 @default.
• W2901533991 hasConceptScore W2901533991C2776412080 @default.
• W2901533991 hasConceptScore W2901533991C2776619155 @default.
• W2901533991 hasConceptScore W2901533991C2778938600 @default.
• W2901533991 hasConceptScore W2901533991C2780494398 @default.
• W2901533991 hasConceptScore W2901533991C33789571 @default.
• W2901533991 hasConceptScore W2901533991C71924100 @default.
• W2901533991 hasConceptScore W2901533991C98274493 @default.
• W2901533991 hasLocation W29015339911 @default.
• W2901533991 hasLocation W29015339912 @default.
• W2901533991 hasOpenAccess W2901533991 @default.
• W2901533991 hasPrimaryLocation W29015339911 @default.
• W2901533991 hasRelatedWork W1556946175 @default.
• W2901533991 hasRelatedWork W1917953303 @default.
• W2901533991 hasRelatedWork W2013592625 @default.
• W2901533991 hasRelatedWork W2048063085 @default.
• W2901533991 hasRelatedWork W2055929037 @default.
• W2901533991 hasRelatedWork W2157127087 @default.
• W2901533991 hasRelatedWork W2170000130 @default.
• W2901533991 hasRelatedWork W2373217907 @default.
• W2901533991 hasRelatedWork W3158616219 @default.

• next