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- W2901574124 abstract "Objective We aimed to design and synthesize a new macromolecule for sentinel node detection to improve the imaging quality and avoid possible adverse effect. Background The imaging of sentinel lymph node has been an important field in the nuclear medicine. A lot of imaging agents have been developed, including 99mTc-sulfer colloid, 99mTc-labeled dextrans and the latest 99mTc-DTPA–mannosyl–dextran. With the technology advanced, the imaging ability of the agents has been better and better. However, there are still some drawbacks. Materials and methods The new macromolecule agent was based on the dextran macromolecule backbone. Then the gly–gly–gly and mannose molecules were conjugated onto the backbone proportionally by targeting two different reaction sites. Once the new macromolecule was labelled with 99mTc, its imaging ability was tested by single-photon emission computed tomography scanning with 99mTc-sulfur colloid as the comparison. Results The average numbers of gly–gyl–gyl and mannosyl groups on the dextran backbone are determined to be ∼1: 2 per dextran. The average molecular diameter and molecular weight are measured to be 5.4±0.7 nm and 10 324 g/mol, respectively. The macromolecule is labelled by 99mTc with 93.2±2.4% radiochemical yield. The lymphatic imaging by single-photon emission computed tomography with the labeled compound showed no worse imaging ability but cost less time than the commercially available 99mTc-sulfur colloid. Conclusion A new macromolecule imaging agent for sentinel node detection has been synthesized with better imaging ability and less imaging time cost." @default.
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- W2901574124 date "2019-02-01" @default.
- W2901574124 modified "2023-10-17" @default.
- W2901574124 title "The synthesis of a new macromolecule for the sentinel node detection" @default.
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- W2901574124 doi "https://doi.org/10.1097/mnm.0000000000000951" @default.
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