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• W2901598361 abstract "To find satisfactory treatment strategies for neuropathic pain syndromes, the cellular mechanisms should be illuminated. Central sensitization is a generator of pain hypersensitivity, and is mainly reflected in neuronal hyperexcitability in pain pathway. Neuronal excitability depends on two components, the synaptic inputs and the intrinsic excitability. Previous studies have focused on the synaptic plasticity in different forms of pain. But little is known about the changes of neuronal intrinsic excitability in neuropathic pain. To address this question, whole-cell patch clamp recordings were performed to study the synaptic transmission and neuronal intrinsic excitability one week after SNI or sham operation in male C57BL/6J mice. We found increased sEPSC (spontaneous excitatory postsynaptic currents) frequency in layer II/III pyramidal neurons of anterior cingulate cortex (ACC) from mice with neuropathic pain. Elevated intrinsic excitability of these neurons after nerve injury was also picked up, which was reflected in gain of input-output curve, ISI, spike threshold and refractory period. Besides firing rate related to neuronal intrinsic excitability, spike timing also plays an important role in neural information processing. The precision of spike timing measured by standard deviation of spike timing (SDST) was decreased in neuropathic pain state. The electrophysiological studies revealed the elevated intrinsic excitation in layer II/III pyramidal neurons of ACC in mice with neuropathic pain, which might contribute to central excitation." @default.
• W2901598361 created "2018-11-29" @default.
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• W2901598361 date "2018-11-21" @default.
• W2901598361 modified "2023-10-14" @default.
• W2901598361 title "The Changes of Intrinsic Excitability of Pyramidal Neurons in Anterior Cingulate Cortex in Neuropathic Pain" @default.
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• W2901598361 doi "https://doi.org/10.3389/fncel.2018.00436" @default.
• W2901598361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6258991" @default.
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