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• W2901604811 endingPage "473" @default.
• W2901604811 startingPage "473" @default.
• W2901604811 abstract "Staphylococcus aureus is a nosocomial pathogen that can cause chronic to persistent infections. Among different mediators of pathogenesis, toxin-antitoxin (TA) systems are emerging as the most prominent. These systems are frequently studied in Escherichia coli and Mycobacterial species but rarely explored in S. aureus. In the present study, we thoroughly analyzed the S. aureus genome and screened all possible TA systems using the Rasta bacteria and toxin-antitoxin database. We further searched E. coli and Mycobacterial TA homologs and selected 67 TA loci as putative TA systems in S. aureus. The host inhibition of growth (HigBA) TA family was predominantly detected in S. aureus. In addition, we detected seven pathogenicity islands in the S. aureus genome that are enriched with virulence genes and contain 26 out of 67 TA systems. We ectopically expressed multiple TA genes in E. coli and S. aureus that exhibited bacteriostatic and bactericidal effects on cell growth. The type I Fst toxin created holes in the cell wall while the TxpA toxin reduced cell size and induced cell wall septation. Besides, we identified a new TA system whose antitoxin functions as a transcriptional autoregulator while the toxin functions as an inhibitor of autoregulation. Altogether, this study provides a plethora of new as well as previously known TA systems that will revitalize the research on S. aureus TA systems." @default.
• W2901604811 created "2018-11-29" @default.
• W2901604811 creator A5016532375 @default.
• W2901604811 creator A5020914629 @default.
• W2901604811 creator A5068067170 @default.
• W2901604811 date "2018-11-14" @default.
• W2901604811 modified "2023-10-11" @default.
• W2901604811 title "Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus" @default.
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• W2901604811 doi "https://doi.org/10.3390/toxins10110473" @default.
• W2901604811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6266405" @default.
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• W2901604811 hasPublicationYear "2018" @default.
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