Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901604955> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2901604955 abstract "Les recepteurs pentameriques canaux (pLGICs) sont des recepteurs neuronaux impliques dans la neurotransmission rapide et qui comprennent les recepteurs suivants : nAchR, GABAR, GlyR or 5HT3R. Lorsqu’ils ne fonctionnent pas correctement ils sont impliques dans des pathologies comme Alzheimer ou Parkinson. Dans cette etude, nous avons realise des simulations de dynamique moleculaire d’un homologue procaryote des pLGICs. Grâce a l’analyse de 2.5 us de simulation nous avons pu capturer la fermeture complete dudit recepteur et decrire un mecanisme de gating. Ce mecanisme en deux etapes, 1) twisting puis 2) blooming semble compatible avec tous les pLGICs. Dans un second temps, nous avons utilise notre connaissance du mecanisme de gating afin de faire des calculs d’energie libre le long du twisting, pour differents complexes proteine/ligands. De cette facon, nous avons pu discriminer entre des ligands actifs et inactifs et ainsi fournir des pistes pour le design de nouveaux traitements." @default.
- W2901604955 created "2018-11-29" @default.
- W2901604955 creator A5007708103 @default.
- W2901604955 date "2017-12-20" @default.
- W2901604955 modified "2023-09-27" @default.
- W2901604955 title "Allosteric modulation of pentameric ligand gated ion channels : from the jiggling of atoms to neuropharmacological strategies" @default.
- W2901604955 hasPublicationYear "2017" @default.
- W2901604955 type Work @default.
- W2901604955 sameAs 2901604955 @default.
- W2901604955 citedByCount "0" @default.
- W2901604955 crossrefType "dissertation" @default.
- W2901604955 hasAuthorship W2901604955A5007708103 @default.
- W2901604955 hasConcept C12554922 @default.
- W2901604955 hasConcept C153911025 @default.
- W2901604955 hasConcept C166342909 @default.
- W2901604955 hasConcept C170493617 @default.
- W2901604955 hasConcept C185592680 @default.
- W2901604955 hasConcept C194544171 @default.
- W2901604955 hasConcept C50254741 @default.
- W2901604955 hasConcept C55493867 @default.
- W2901604955 hasConcept C71240020 @default.
- W2901604955 hasConcept C86803240 @default.
- W2901604955 hasConceptScore W2901604955C12554922 @default.
- W2901604955 hasConceptScore W2901604955C153911025 @default.
- W2901604955 hasConceptScore W2901604955C166342909 @default.
- W2901604955 hasConceptScore W2901604955C170493617 @default.
- W2901604955 hasConceptScore W2901604955C185592680 @default.
- W2901604955 hasConceptScore W2901604955C194544171 @default.
- W2901604955 hasConceptScore W2901604955C50254741 @default.
- W2901604955 hasConceptScore W2901604955C55493867 @default.
- W2901604955 hasConceptScore W2901604955C71240020 @default.
- W2901604955 hasConceptScore W2901604955C86803240 @default.
- W2901604955 hasLocation W29016049551 @default.
- W2901604955 hasOpenAccess W2901604955 @default.
- W2901604955 hasPrimaryLocation W29016049551 @default.
- W2901604955 hasRelatedWork W2784790176 @default.
- W2901604955 hasRelatedWork W2982282629 @default.
- W2901604955 hasRelatedWork W2994974293 @default.
- W2901604955 hasRelatedWork W3005241319 @default.
- W2901604955 hasRelatedWork W3013785441 @default.
- W2901604955 hasRelatedWork W3016249774 @default.
- W2901604955 hasRelatedWork W3027661357 @default.
- W2901604955 hasRelatedWork W3030368093 @default.
- W2901604955 hasRelatedWork W3040914808 @default.
- W2901604955 hasRelatedWork W3043216507 @default.
- W2901604955 hasRelatedWork W3131490443 @default.
- W2901604955 hasRelatedWork W3143561074 @default.
- W2901604955 hasRelatedWork W3151432939 @default.
- W2901604955 hasRelatedWork W3161150634 @default.
- W2901604955 hasRelatedWork W3164098695 @default.
- W2901604955 hasRelatedWork W3164722158 @default.
- W2901604955 hasRelatedWork W3205931168 @default.
- W2901604955 hasRelatedWork W3209411421 @default.
- W2901604955 hasRelatedWork W61752489 @default.
- W2901604955 hasRelatedWork W3110824448 @default.
- W2901604955 isParatext "false" @default.
- W2901604955 isRetracted "false" @default.
- W2901604955 magId "2901604955" @default.
- W2901604955 workType "dissertation" @default.