FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901605031> ?p ?o ?g. }

• W2901605031 endingPage "S133" @default.
• W2901605031 startingPage "S133" @default.
• W2901605031 abstract "Introduction Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a potentially life-threatening severe cutaneous adverse drug reaction (SCAR) that can be triggered by medications. Toxic Epidermal Necrolysis (TEN) is also a type of SCAR. To the best of our knowledge, we present a first known clear case of DRESS which progressed to clinical TEN and was successfully treated. Case Description A 17-year old female was started on Lamotrigine and Escitalopram for a mood disorder. One week later, she developed tender cervical lymphadenopathy, fevers, and abdominal discomfort. About 2.5 weeks after starting these two medications, she developed a raised, pruritic, erythematous rash on her arms. Although the medication was discontinued, she failed to improve and developed facial angioedema, hepatic failure, eosinophilia and atypical lymphocytosis - all concerning signs for DRESS. Skin biopsy confirmed perivascular lymphocytic infiltrate with scattered eosinophils supporting DRESS. She was treated with intravenous immunoglobulin and eventually discharged home with a resolving rash. As Prednisone was tapered, the patient was readmitted with concerns for relapsing DRESS. She went on to develop TEN with mucosal involvement as well as greater than 30 percent skin involvement. She was successfully treated with a combination of Cyclosporine and high dose Prednisone. Discussion There is paucity of literature on SCAR overlap syndromes and we acknowledge the ambiguity and difficulty with this diagnosis given the overlapping presentation with SCAR syndromes. Although the mortality rate tends to be quite high for SCAR overlap syndromes, our patient was successfully treated with a combination of IVIG, steroids and Cyclosporine. Progression towards TEN. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a potentially life-threatening severe cutaneous adverse drug reaction (SCAR) that can be triggered by medications. Toxic Epidermal Necrolysis (TEN) is also a type of SCAR. To the best of our knowledge, we present a first known clear case of DRESS which progressed to clinical TEN and was successfully treated. A 17-year old female was started on Lamotrigine and Escitalopram for a mood disorder. One week later, she developed tender cervical lymphadenopathy, fevers, and abdominal discomfort. About 2.5 weeks after starting these two medications, she developed a raised, pruritic, erythematous rash on her arms. Although the medication was discontinued, she failed to improve and developed facial angioedema, hepatic failure, eosinophilia and atypical lymphocytosis - all concerning signs for DRESS. Skin biopsy confirmed perivascular lymphocytic infiltrate with scattered eosinophils supporting DRESS. She was treated with intravenous immunoglobulin and eventually discharged home with a resolving rash. As Prednisone was tapered, the patient was readmitted with concerns for relapsing DRESS. She went on to develop TEN with mucosal involvement as well as greater than 30 percent skin involvement. She was successfully treated with a combination of Cyclosporine and high dose Prednisone. There is paucity of literature on SCAR overlap syndromes and we acknowledge the ambiguity and difficulty with this diagnosis given the overlapping presentation with SCAR syndromes. Although the mortality rate tends to be quite high for SCAR overlap syndromes, our patient was successfully treated with a combination of IVIG, steroids and Cyclosporine. Progression towards TEN." @default.
• W2901605031 created "2018-11-29" @default.
• W2901605031 creator A5033844142 @default.
• W2901605031 creator A5057173578 @default.
• W2901605031 creator A5087257669 @default.
• W2901605031 creator A5089160822 @default.
• W2901605031 date "2018-11-01" @default.
• W2901605031 modified "2023-09-25" @default.
• W2901605031 title "DRESS TO TEN: IS THIS A CONTINUUM?" @default.
• W2901605031 doi "https://doi.org/10.1016/j.anai.2018.09.441" @default.
• W2901605031 hasPublicationYear "2018" @default.
• W2901605031 type Work @default.
• W2901605031 sameAs 2901605031 @default.
• W2901605031 citedByCount "1" @default.
• W2901605031 countsByYear W29016050312018 @default.
• W2901605031 crossrefType "journal-article" @default.
• W2901605031 hasAuthorship W2901605031A5033844142 @default.
• W2901605031 hasAuthorship W2901605031A5057173578 @default.
• W2901605031 hasAuthorship W2901605031A5087257669 @default.
• W2901605031 hasAuthorship W2901605031A5089160822 @default.
• W2901605031 hasConcept C118552586 @default.
• W2901605031 hasConcept C141071460 @default.
• W2901605031 hasConcept C142724271 @default.
• W2901605031 hasConcept C16005928 @default.
• W2901605031 hasConcept C2775934546 @default.
• W2901605031 hasConcept C2777129736 @default.
• W2901605031 hasConcept C2778186239 @default.
• W2901605031 hasConcept C2778570526 @default.
• W2901605031 hasConcept C2778720950 @default.
• W2901605031 hasConcept C2778802184 @default.
• W2901605031 hasConcept C2779134260 @default.
• W2901605031 hasConcept C2779655305 @default.
• W2901605031 hasConcept C2780439664 @default.
• W2901605031 hasConcept C2780664588 @default.
• W2901605031 hasConcept C71924100 @default.
• W2901605031 hasConceptScore W2901605031C118552586 @default.
• W2901605031 hasConceptScore W2901605031C141071460 @default.
• W2901605031 hasConceptScore W2901605031C142724271 @default.
• W2901605031 hasConceptScore W2901605031C16005928 @default.
• W2901605031 hasConceptScore W2901605031C2775934546 @default.
• W2901605031 hasConceptScore W2901605031C2777129736 @default.
• W2901605031 hasConceptScore W2901605031C2778186239 @default.
• W2901605031 hasConceptScore W2901605031C2778570526 @default.
• W2901605031 hasConceptScore W2901605031C2778720950 @default.
• W2901605031 hasConceptScore W2901605031C2778802184 @default.
• W2901605031 hasConceptScore W2901605031C2779134260 @default.
• W2901605031 hasConceptScore W2901605031C2779655305 @default.
• W2901605031 hasConceptScore W2901605031C2780439664 @default.
• W2901605031 hasConceptScore W2901605031C2780664588 @default.
• W2901605031 hasConceptScore W2901605031C71924100 @default.
• W2901605031 hasIssue "5" @default.
• W2901605031 hasLocation W29016050311 @default.
• W2901605031 hasOpenAccess W2901605031 @default.
• W2901605031 hasPrimaryLocation W29016050311 @default.
• W2901605031 hasRelatedWork W2016310235 @default.
• W2901605031 hasRelatedWork W2080894976 @default.
• W2901605031 hasRelatedWork W2085907742 @default.
• W2901605031 hasRelatedWork W2204930520 @default.
• W2901605031 hasRelatedWork W2259928828 @default.
• W2901605031 hasRelatedWork W2576379769 @default.
• W2901605031 hasRelatedWork W2901605031 @default.
• W2901605031 hasRelatedWork W3005064763 @default.
• W2901605031 hasRelatedWork W3126985475 @default.
• W2901605031 hasRelatedWork W2186580693 @default.
• W2901605031 hasVolume "121" @default.
• W2901605031 isParatext "false" @default.
• W2901605031 isRetracted "false" @default.
• W2901605031 magId "2901605031" @default.
• W2901605031 workType "article" @default.