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• W2901611732 abstract "Cough is one of the most common symptoms for seeking medical care (1, 2). If cough is going to cause that much trouble, it better be worth it, and the clinical evidence is that indeed it is. Patients with impaired cough due to neuromuscular disease or postoperative sedation suffer high rates of atelectasis and pneumonia due to the failure to clear secretions from the airways, and there is evidence that a heightened cough reflex improves health (3, 4). Chief among airway secretions is mucus, and, in PNAS, Button et al. (5) analyze the biophysical requirements for a cough to separate adherent mucus from an airway wall. Before diving into the details, it is worth reviewing what is known about the biochemistry of mucus and the forces generated by a cough.Mucus is an important defense against perturbations from the outside world at wet epithelial surfaces throughout the body, including the eyes, airways, gastrointestinal tract, and genitourinary tract. Its importance is revealed when the mucus barrier malfunctions in disorders such as dry eyes or inflammatory bowel disease. Mucus is a remarkable and protean substance, with properties on the border between a viscous fluid and a soft elastic solid. Its properties primarily reflect the interactions of mucin glycoproteins (∼0.5% of mass) with water (∼98%) and salts (∼1%). Globular proteins are also present in normal mucus (∼0.5% of mass) but do not have a major impact on the physical properties of mucus unless they and DNA are present in abnormal amounts during pathologic processes (3). Mucins are very large highly glycosylated molecules, accounting for their avid interactions with water. Secreted mucins polymerize into chains and networks that confer on mucus its semisolid consistency. However, the physical properties of mucus are highly dependent on mucin concentration, with dilute mucus acting like a … [↵][1]1Email: bdickey{at}mdanderson.org. [1]: #xref-corresp-1-1" @default.
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• W2901611732 date "2018-11-20" @default.
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• W2901611732 title "What it takes for a cough to expel mucus from the airway" @default.
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• W2901611732 doi "https://doi.org/10.1073/pnas.1817484115" @default.
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