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• W2901630393 abstract "There is currently no universally accepted standard of care treatment for low-grade gliomas, a molecularly heterogeneous group of tumors with similarly heterogeneous clinical outcomes. Risk stratification by clinical and molecular features is useful to help determine which patients benefit the most from adjuvant treatment. The addition of combination chemotherapy with procarbazine, lomustine, and vincristine confers survival advantage, as likely does temozolomide, but radiochemotherapy may not be appropriate for all patients owing to its toxicity profile. We review the approach to treatment in patients with low-grade gliomas with an emphasis on the clinical trials focusing on adjuvant chemotherapy in this population." @default.
• W2901630393 created "2018-11-29" @default.
• W2901630393 creator A5030819228 @default.
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• W2901630393 date "2019-01-01" @default.
• W2901630393 modified "2023-09-26" @default.
• W2901630393 title "Chemotherapy Treatment and Trials in Low-Grade Gliomas" @default.
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• W2901630393 doi "https://doi.org/10.1016/j.nec.2018.08.007" @default.
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