FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901632435> ?p ?o ?g. }

• W2901632435 endingPage "183" @default.
• W2901632435 startingPage "174" @default.
• W2901632435 abstract "Overexpression of mitotic arrest deficient 2 (MAD2) and/or cell division cycle 20 (CDC20) in the spindle assembly checkpoint leads to chromosomal instability and aneuploidy. Cell-in-cell (CIC) structures are formed by the process where cancer or immune cells are internalized into adjacent host cancer cells. Here, we investigated the clinicopathological significances of spindle assembly checkpoint protein overexpression and CIC structures in 829 cases of normal, premalignant, and gastric cancer (GC) lesions. MAD2 and CDC20 expressions were significantly increased in intestinal metaplasia, low-grade dysplasia, high-grade dysplasia (HGD), and early GC than normal mucosa, and their expression levels were the highest in HGD. Interestingly, CDC20 immunohistochemistry specifically stained the outer cells of CIC structures, which were the most frequently observed in early GC. In univariate analyses, MAD2 and CDC20 overexpressions and CIC formation were associated with older age, intestinal histology, lower tumor-node-metastasis stage, and longer recurrence-free survival and cancer-specific survival of GC patients. In multivariate survival analyses, MAD2 and CDC20 overexpressions were associated with better recurrence-free survival (hazard ratio, 0.61; P = .012) and cancer-specific survival (hazard ratio, 0.63; P = .043), respectively. In conclusion, MAD2 and CDC20 are the most expressed in HGD, suggesting their roles in the early stage of gastric carcinogenesis, whereas their overexpressions in GC are associated with intestinal histology and favorable clinicopathological parameters, which may be useful for immunohistochemical classification of chromosomal instability–type GC. Moreover, CDC20 is a novel immunohistochemical marker for highlighting CIC structures." @default.
• W2901632435 created "2018-11-29" @default.
• W2901632435 creator A5001129813 @default.
• W2901632435 creator A5049273599 @default.
• W2901632435 creator A5077546080 @default.
• W2901632435 creator A5085982516 @default.
• W2901632435 date "2019-03-01" @default.
• W2901632435 modified "2023-09-30" @default.
• W2901632435 title "Spindle assembly checkpoint MAD2 and CDC20 overexpressions and cell-in-cell formation in gastric cancer and its precursor lesions" @default.
• W2901632435 cites W1787257297 @default.
• W2901632435 cites W1963750681 @default.
• W2901632435 cites W1969722712 @default.
• W2901632435 cites W1984328656 @default.
• W2901632435 cites W2007877171 @default.
• W2901632435 cites W2013193231 @default.
• W2901632435 cites W2013213027 @default.
• W2901632435 cites W2021579554 @default.
• W2901632435 cites W2030202463 @default.
• W2901632435 cites W2036616013 @default.
• W2901632435 cites W2037295429 @default.
• W2901632435 cites W2059640573 @default.
• W2901632435 cites W2060714341 @default.
• W2901632435 cites W2066662245 @default.
• W2901632435 cites W2075203982 @default.
• W2901632435 cites W2081772067 @default.
• W2901632435 cites W2083643696 @default.
• W2901632435 cites W2087625931 @default.
• W2901632435 cites W2090407379 @default.
• W2901632435 cites W2100211280 @default.
• W2901632435 cites W2112497627 @default.
• W2901632435 cites W2126547130 @default.
• W2901632435 cites W2145393673 @default.
• W2901632435 cites W2148287035 @default.
• W2901632435 cites W2312633322 @default.
• W2901632435 cites W2528481396 @default.
• W2901632435 cites W2606614539 @default.
• W2901632435 cites W2612895811 @default.
• W2901632435 cites W2619753693 @default.
• W2901632435 cites W2737578400 @default.
• W2901632435 cites W2768981791 @default.
• W2901632435 cites W2876484164 @default.
• W2901632435 doi "https://doi.org/10.1016/j.humpath.2018.10.029" @default.
• W2901632435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30448220" @default.
• W2901632435 hasPublicationYear "2019" @default.
• W2901632435 type Work @default.
• W2901632435 sameAs 2901632435 @default.
• W2901632435 citedByCount "21" @default.
• W2901632435 countsByYear W29016324352019 @default.
• W2901632435 countsByYear W29016324352020 @default.
• W2901632435 countsByYear W29016324352021 @default.
• W2901632435 countsByYear W29016324352022 @default.
• W2901632435 countsByYear W29016324352023 @default.
• W2901632435 crossrefType "journal-article" @default.
• W2901632435 hasAuthorship W2901632435A5001129813 @default.
• W2901632435 hasAuthorship W2901632435A5049273599 @default.
• W2901632435 hasAuthorship W2901632435A5077546080 @default.
• W2901632435 hasAuthorship W2901632435A5085982516 @default.
• W2901632435 hasConcept C104317684 @default.
• W2901632435 hasConcept C105696609 @default.
• W2901632435 hasConcept C121608353 @default.
• W2901632435 hasConcept C126322002 @default.
• W2901632435 hasConcept C140752955 @default.
• W2901632435 hasConcept C142724271 @default.
• W2901632435 hasConcept C204232928 @default.
• W2901632435 hasConcept C2775894508 @default.
• W2901632435 hasConcept C2777563682 @default.
• W2901632435 hasConcept C29537977 @default.
• W2901632435 hasConcept C30481170 @default.
• W2901632435 hasConcept C502942594 @default.
• W2901632435 hasConcept C55493867 @default.
• W2901632435 hasConcept C71924100 @default.
• W2901632435 hasConcept C86803240 @default.
• W2901632435 hasConceptScore W2901632435C104317684 @default.
• W2901632435 hasConceptScore W2901632435C105696609 @default.
• W2901632435 hasConceptScore W2901632435C121608353 @default.
• W2901632435 hasConceptScore W2901632435C126322002 @default.
• W2901632435 hasConceptScore W2901632435C140752955 @default.
• W2901632435 hasConceptScore W2901632435C142724271 @default.
• W2901632435 hasConceptScore W2901632435C204232928 @default.
• W2901632435 hasConceptScore W2901632435C2775894508 @default.
• W2901632435 hasConceptScore W2901632435C2777563682 @default.
• W2901632435 hasConceptScore W2901632435C29537977 @default.
• W2901632435 hasConceptScore W2901632435C30481170 @default.
• W2901632435 hasConceptScore W2901632435C502942594 @default.
• W2901632435 hasConceptScore W2901632435C55493867 @default.
• W2901632435 hasConceptScore W2901632435C71924100 @default.
• W2901632435 hasConceptScore W2901632435C86803240 @default.
• W2901632435 hasFunder F4320322120 @default.
• W2901632435 hasLocation W29016324351 @default.
• W2901632435 hasLocation W29016324352 @default.
• W2901632435 hasOpenAccess W2901632435 @default.
• W2901632435 hasPrimaryLocation W29016324351 @default.
• W2901632435 hasRelatedWork W1992332176 @default.
• W2901632435 hasRelatedWork W2034876822 @default.
• W2901632435 hasRelatedWork W2055479802 @default.
• W2901632435 hasRelatedWork W2072602519 @default.
• W2901632435 hasRelatedWork W2145143834 @default.
• W2901632435 hasRelatedWork W2393033873 @default.

• next