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• W2901645946 endingPage "e13912" @default.
• W2901645946 startingPage "e13912" @default.
• W2901645946 abstract "We investigated the potential adverse effects of hyperaldosteronism and/or hypoestrogenism on cardiac phenotype, and examined their combined effects in female mice overexpressing cardiac aldosterone synthase (AS). We focused on some signaling cascades challenging defensive responses to adapt and/or to survive in the face of double deleterious stresses, such as Ca2+-homeostasis, pro/anti-hypertrophic, endoplasmic reticulum stress (ER stress), pro- or anti-apoptotic effectors, and MAP kinase activation, and redox signaling. These protein expressions were assessed by immunoblotting at 9 weeks after surgery. Female wild type (FWT) and FAS mice were fed with phytoestrogen-free diet; underwent ovariectomy (Ovx) or sham-operation (Sham). Ovx increased gain weight and hypertrophy index. Transthoracic echocardiograghy was performed. Both Ovx-induced heart rate decrease and fractional shortening increase were associated with collagen type III shift. Cardiac estrogen receptor (ERα, ERβ) protein expression levels were downregulated in Ovx mice. Hypoestrogenism increased plasma aldosterone and MR protein expression in FAS mice. Both aldosterone and Ovx played as mirror effects on up and downstream signaling effectors of calcium/redox homeostasis, apoptosis, such as concomitant CaMKII activation and calcineurin down–regulation, MAP kinase inhibition (ERK1/2, p38 MAPK) and Akt activation. The ratio Bcl2/Bax is in favor to promote cell survivor. Finally, myocardium had dynamically orchestrated multiple signaling cascades to restore tolerance to hostile environment thereby contributing to a better maintenance of Ca2+/redox homeostasis. Ovx-induced collagen type III isoform shift and its upregulation may be important for the biomechanical transduction of the heart and the recovery of cardiac function in FAS mice. OVX antagonized aldosterone signaling pathways." @default.
• W2901645946 created "2018-11-29" @default.
• W2901645946 creator A5009679328 @default.
• W2901645946 creator A5017917935 @default.
• W2901645946 creator A5077167531 @default.
• W2901645946 date "2018-11-01" @default.
• W2901645946 modified "2023-10-10" @default.
• W2901645946 title "Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice" @default.
• W2901645946 cites W1144677986 @default.
• W2901645946 cites W116732461 @default.
• W2901645946 cites W1518607321 @default.
• W2901645946 cites W1537431404 @default.
• W2901645946 cites W1573821584 @default.
• W2901645946 cites W1586300346 @default.
• W2901645946 cites W1876724481 @default.
• W2901645946 cites W1928844142 @default.
• W2901645946 cites W1969052554 @default.
• W2901645946 cites W1969150166 @default.
• W2901645946 cites W1970254730 @default.
• W2901645946 cites W1977143420 @default.
• W2901645946 cites W1977186450 @default.
• W2901645946 cites W1979898067 @default.
• W2901645946 cites W1984444802 @default.
• W2901645946 cites W1984948100 @default.
• W2901645946 cites W1985141838 @default.
• W2901645946 cites W1991967118 @default.
• W2901645946 cites W1996522179 @default.
• W2901645946 cites W1997690040 @default.
• W2901645946 cites W2000165700 @default.
• W2901645946 cites W2000765231 @default.
• W2901645946 cites W2000837719 @default.
• W2901645946 cites W2002662427 @default.
• W2901645946 cites W2003197337 @default.
• W2901645946 cites W2006612035 @default.
• W2901645946 cites W2006856548 @default.
• W2901645946 cites W2007114641 @default.
• W2901645946 cites W2010211998 @default.
• W2901645946 cites W2012154384 @default.
• W2901645946 cites W2013369738 @default.
• W2901645946 cites W2019796933 @default.
• W2901645946 cites W2019814232 @default.
• W2901645946 cites W2023394535 @default.
• W2901645946 cites W2025512197 @default.
• W2901645946 cites W2028732654 @default.
• W2901645946 cites W2028733465 @default.
• W2901645946 cites W2036043627 @default.
• W2901645946 cites W2036864058 @default.
• W2901645946 cites W2040320225 @default.
• W2901645946 cites W2042340757 @default.
• W2901645946 cites W2044059133 @default.
• W2901645946 cites W2049235717 @default.
• W2901645946 cites W2054574813 @default.
• W2901645946 cites W2056286161 @default.
• W2901645946 cites W2060018075 @default.
• W2901645946 cites W2060282632 @default.
• W2901645946 cites W2061245367 @default.
• W2901645946 cites W2064194224 @default.
• W2901645946 cites W2064365601 @default.
• W2901645946 cites W2064577443 @default.
• W2901645946 cites W2067956701 @default.
• W2901645946 cites W2072219050 @default.
• W2901645946 cites W2072881240 @default.
• W2901645946 cites W2078258474 @default.
• W2901645946 cites W2086392932 @default.
• W2901645946 cites W2090897053 @default.
• W2901645946 cites W2093009414 @default.
• W2901645946 cites W2093189154 @default.
• W2901645946 cites W2098398336 @default.
• W2901645946 cites W2100205148 @default.
• W2901645946 cites W2102041759 @default.
• W2901645946 cites W2105265963 @default.
• W2901645946 cites W2110920739 @default.
• W2901645946 cites W2114159500 @default.
• W2901645946 cites W2115233843 @default.
• W2901645946 cites W2116389513 @default.
• W2901645946 cites W2121582272 @default.
• W2901645946 cites W2122653467 @default.
• W2901645946 cites W2125521951 @default.
• W2901645946 cites W2128314512 @default.
• W2901645946 cites W2131268302 @default.
• W2901645946 cites W2132692279 @default.
• W2901645946 cites W2134286592 @default.
• W2901645946 cites W2137262559 @default.
• W2901645946 cites W2142274635 @default.
• W2901645946 cites W2142604754 @default.
• W2901645946 cites W2147429178 @default.
• W2901645946 cites W2150011193 @default.
• W2901645946 cites W2150407444 @default.
• W2901645946 cites W2150694499 @default.
• W2901645946 cites W2151926452 @default.
• W2901645946 cites W2152094259 @default.
• W2901645946 cites W2154937055 @default.
• W2901645946 cites W2156976038 @default.
• W2901645946 cites W2157191747 @default.
• W2901645946 cites W2159401680 @default.
• W2901645946 cites W2160086057 @default.
• W2901645946 cites W2162695817 @default.
• W2901645946 cites W2163275136 @default.

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