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- W2901646965 endingPage "258" @default.
- W2901646965 startingPage "246" @default.
- W2901646965 abstract "Endoplasmic reticulum (ER) is a crucial single membrane organelle that acts as a quality control system for cellular proteins as it is intricately involved in their synthesis, folding and trafficking to the respective targets. Type 2 diabetes is characterized by enhanced blood glucose level that promotes insulin resistance and hampers cellular glucose metabolism. Hyperglycemia provokes mitochondrial ROS production and glycation of proteins which exert a tremendous load on ER for conventional refolding of misfolded/unfolded and nascent proteins that perturb ER homeostasis resulting in apoptotic cell death. Impairment in ER functions is suspected to be through specific ER membrane-bound proteins known as Unfolded Protein Response (UPR) sensor proteins. Conformational changes in these proteins induce oligomerization and cross-autophosphorylation which facilitate processes required for the restoration of ER homeostatic imbalance. Multiple studies have reported the involvement of UPR mediated autophagy and apoptotic pathways in the progression of metabolic disorders including diabetes, cardiac ischemia/reperfusion injury and hypoxia-mediated cell death. In this review, the involvement of UPR pathways in the progression of diabetes associated complications have been addressed, which underscores molecular crosstalks during neuropathy, nephropathy, hepatic injury and retinopathy. A better understanding of these molecular interventions may reveal advanced therapeutic approaches for preventing diabetic comorbidities. The article also highlights the importance of phytochemicals that are emerging as novel ER stress inhibitors and are being explored for targeted interaction in preventing cell death responses during diabetes." @default.
- W2901646965 created "2018-11-29" @default.
- W2901646965 creator A5027985341 @default.
- W2901646965 creator A5036169096 @default.
- W2901646965 creator A5064482385 @default.
- W2901646965 date "2019-01-01" @default.
- W2901646965 modified "2023-09-29" @default.
- W2901646965 title "Emerging role of Unfolded Protein Response (UPR) mediated proteotoxic apoptosis in diabetes" @default.
- W2901646965 cites W1044743974 @default.
- W2901646965 cites W1492991941 @default.
- W2901646965 cites W1600715668 @default.
- W2901646965 cites W1697178647 @default.
- W2901646965 cites W1765185969 @default.
- W2901646965 cites W1776429102 @default.
- W2901646965 cites W1819701782 @default.
- W2901646965 cites W1855830668 @default.
- W2901646965 cites W1940688833 @default.
- W2901646965 cites W1949377242 @default.
- W2901646965 cites W1966157599 @default.
- W2901646965 cites W1966671518 @default.
- W2901646965 cites W1968834521 @default.
- W2901646965 cites W1970195253 @default.
- W2901646965 cites W1972379925 @default.
- W2901646965 cites W1974068337 @default.
- W2901646965 cites W1976161806 @default.
- W2901646965 cites W1976496691 @default.
- W2901646965 cites W1976531450 @default.
- W2901646965 cites W1976943917 @default.
- W2901646965 cites W1977262241 @default.
- W2901646965 cites W1978216048 @default.
- W2901646965 cites W1978390469 @default.
- W2901646965 cites W1978999653 @default.
- W2901646965 cites W1979782246 @default.
- W2901646965 cites W1985042459 @default.
- W2901646965 cites W1988973837 @default.
- W2901646965 cites W1990057935 @default.
- W2901646965 cites W1990979658 @default.
- W2901646965 cites W1991250346 @default.
- W2901646965 cites W1995651519 @default.
- W2901646965 cites W1997464771 @default.
- W2901646965 cites W1997573654 @default.
- W2901646965 cites W1997745787 @default.
- W2901646965 cites W1998300009 @default.
- W2901646965 cites W2001399725 @default.
- W2901646965 cites W2004873298 @default.
- W2901646965 cites W2006058363 @default.
- W2901646965 cites W2007743440 @default.
- W2901646965 cites W2009062388 @default.
- W2901646965 cites W2012792172 @default.
- W2901646965 cites W2016294684 @default.
- W2901646965 cites W2019141360 @default.
- W2901646965 cites W2023975386 @default.
- W2901646965 cites W2030818171 @default.
- W2901646965 cites W2033754437 @default.
- W2901646965 cites W2034657491 @default.
- W2901646965 cites W2036143320 @default.
- W2901646965 cites W2036377986 @default.
- W2901646965 cites W2037010692 @default.
- W2901646965 cites W2041655090 @default.
- W2901646965 cites W2042546405 @default.
- W2901646965 cites W2043029086 @default.
- W2901646965 cites W2043275103 @default.
- W2901646965 cites W2043387126 @default.
- W2901646965 cites W2043757786 @default.
- W2901646965 cites W2045403903 @default.
- W2901646965 cites W2046290896 @default.
- W2901646965 cites W2046561887 @default.
- W2901646965 cites W2048209604 @default.
- W2901646965 cites W2049110564 @default.
- W2901646965 cites W2049432355 @default.
- W2901646965 cites W2057518766 @default.
- W2901646965 cites W2058235401 @default.
- W2901646965 cites W2059035026 @default.
- W2901646965 cites W2065084983 @default.
- W2901646965 cites W2068335749 @default.
- W2901646965 cites W2069924169 @default.
- W2901646965 cites W2071717526 @default.
- W2901646965 cites W2075127177 @default.
- W2901646965 cites W2075429429 @default.
- W2901646965 cites W2077023300 @default.
- W2901646965 cites W2079578062 @default.
- W2901646965 cites W2080797115 @default.
- W2901646965 cites W2081550541 @default.
- W2901646965 cites W2081931975 @default.
- W2901646965 cites W2085201901 @default.
- W2901646965 cites W2086444426 @default.
- W2901646965 cites W2086626108 @default.
- W2901646965 cites W2087618734 @default.
- W2901646965 cites W2089894176 @default.
- W2901646965 cites W2090475821 @default.
- W2901646965 cites W2092970668 @default.
- W2901646965 cites W2094185904 @default.
- W2901646965 cites W2094327138 @default.
- W2901646965 cites W2096396734 @default.
- W2901646965 cites W2096987196 @default.
- W2901646965 cites W2097016322 @default.
- W2901646965 cites W2097681320 @default.
- W2901646965 cites W2099125910 @default.