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• W2901652008 abstract "Bruno1Bruno M.J. Pancreatic cancer screening in high-risk individuals: Ready for prime time?.Gastrointest Endosc. 2018; 87: 1451-1453Abstract Full Text Full Text PDF Scopus (4) Google Scholar must be commended for his wise and critical analysis when commenting on the study reporting screening pancreatic cancer in high-risk individuals with germline genetic mutations.2DaVee T. Coronel E. Papafragkakis C. et al.Pancreatic cancer screening in high-risk individuals with germline genetic mutations.Gastrointest Endosc. 2018; 87: 1443-1450Abstract Full Text Full Text PDF PubMed Scopus (39) Google Scholar Indeed, medicine is now too frequently more about hype than hope. Exaggerated claims are such an epidemic3Braillon A. Sciensationalism.Am J Med. 2011; 124: e13Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar that Bruno introduced his conclusion thus: “…this editorial might be perceived as pessimistic….”! In my humble opinion, the difference between pessimistic people and optimistic ones is only that the former are well-informed and wise. The observational study published in Gastrointestinal Endoscopy coincided with a similar one in another journal, also negative but “optimistic.”4Gangi A. Malafa M. Klapman J. Endoscopic ultrasound-based pancreatic cancer screening of high-risk individuals: a prospective observational trial.Pancreas. 2018; 47: 586-591Crossref PubMed Scopus (18) Google Scholar In contrast to the one published in Gastrointestinal Endoscopy,2DaVee T. Coronel E. Papafragkakis C. et al.Pancreatic cancer screening in high-risk individuals with germline genetic mutations.Gastrointest Endosc. 2018; 87: 1443-1450Abstract Full Text Full Text PDF PubMed Scopus (39) Google Scholar it failed to provide data about smoking, alcohol use, and obesity.5Camilleri M. Malhi H. Acosta A. Gastrointestinal complications of obesity.Gastroenterology. 2017; 152: 1656-1670Abstract Full Text Full Text PDF PubMed Scopus (101) Google Scholar These most prevalent conditions are avoidable causes of pancreatic cancer (and premature mortality), and multifactorial lifestyle interventions by trained professionals are robustly evidence-based for effectiveness.6Baumann S. Toft U. Aadahl M. et al.The long-term effect of a population-based life-style intervention on smoking and alcohol consumption. The Inter99 Study--a randomized controlled trial.Addiction. 2015; 110: 1853-1860Crossref PubMed Scopus (30) Google Scholar A letter to the editor requesting these overlooked data was rejected, and appeals for reconsideration received no responses. Gastrointestinal Endoscopy and the publisher must be commended for their professionalism. The author disclosed no financial relationships relevant to this publication. Pancreatic cancer screening in high-risk individuals: Ready for prime time?Gastrointestinal EndoscopyVol. 87Issue 6PreviewResearch and scientific evidence that screening in individuals at high risk for the development of pancreatic cancer is worthwhile, let alone in the general population, stays far behind compared with screening for prostate, colon, or, for example, breast cancer. Even for those programs, for which dozens of studies have already been published, including randomized controlled trials, some serious concerns have been voiced about their true effectiveness.1,2 Although cancer screening may be linked to fewer deaths from tumors, studies are usually underpowered to detect overall mortality benefits, and finding cancers doesn’t necessarily save lives when fatalities from all causes are taken into account, including the harmful effects of the tests themselves or of unnecessary treatments. Full-Text PDF" @default.
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• W2901652008 date "2018-12-01" @default.
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• W2901652008 title "Screening for pancreatic cancer and… scientific integrity" @default.
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• W2901652008 doi "https://doi.org/10.1016/j.gie.2018.06.023" @default.
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