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• W2901682024 endingPage "1200" @default.
• W2901682024 startingPage "1193" @default.
• W2901682024 abstract "Lung injury is a hydrogen sulfide (H2S)-associated complication with high mortality in acute pancreatitis (AP) cases. Herein, we used Prussian Blue (PB) as a H2S-responsive acceptor to develop a novel pure-inorganic upconversion nanoprobe for detecting and eliminating H2S, which can be used for diagnosing AP and alleviating lung injury. Upconversion nanoprobes with 5 nm PB shells were optimized to achieve outstanding in vitro H2S detection capacity (linear range: 0-150 μM, LOD: 50 nM), which met the in vivo serum H2S range, and thus were feasible for imaging H2S in vivo. More importantly, when combined with the traditional H2S synthetase inhibitor dl-PAG, the nanoprobes also served as a therapeutic agent that synergistically alleviated lung injury. As PB is an FDA-approved drug, our work proposes a potential clinical modality for the early diagnosis of AP, which will decrease lung injury-induced mortality and increase the survival rates of AP cases." @default.
• W2901682024 created "2018-11-29" @default.
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• W2901682024 date "2019-01-01" @default.
• W2901682024 modified "2023-10-14" @default.
• W2901682024 title "Rationally designed pure-inorganic upconversion nanoprobes for ultra-highly selective hydrogen sulfide imaging and elimination <i>in vivo</i>" @default.
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• W2901682024 doi "https://doi.org/10.1039/c8sc04464c" @default.
• W2901682024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6349023" @default.
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• W2901682024 hasPublicationYear "2019" @default.
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