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- W2901688693 abstract "Objective: To determine frontal lobe function in pediatric temporal lobe epilepsy via fMRI. Background: Chronic temporal lobe epilepsy (TLE) in both children and adults is now known to be associated with widespread neuropsychological abnormalities, including Executive Function (EF). The timing and course of these diffuse cognitive abnormalities is yet to be clarified as well as the structural and functional correlates of abnormal EF. In the present study we examine EF in children with new onset TLE and its substrate using functional neuroimaging. Design/Methods: Twenty-nine children (14 TLE subjects, 15 controls, ages 8–16) underwent functional neuroimaging while performing the N-Back task. In this task, participants were presented with a series of single consonant letters and instructed to press a button with their dominant hand when the presented letter was the same as the one presented n letters ago. Subjects were tested using 2 load conditions: 0-back (‘press for Q’) and 2-back. Each subject performed low and high working memory (WM) load fMRI runs, in a counterbalanced order, each lasting 310 seconds. Results: TLE patients had slower reaction time in the 0-back task (p = 0.014), but accuracy did not significantly differ from controls (p = 0.149) TLE participants had both slower reaction time (p = 0.01) and poorer accuracy (p = 0.04) on working memory performance in the 2-back task Between-group differences TLE participants exhibited areas of reduced task activation compared to controls (p Conclusions: Executive dysfunction is observed in children with newly diagnosed TLE using functional neuroimaging. Compared to controls, children with TLE demonstrate reduced activation in the executive control network which correlates with a classic working memory task (a component of executive function) on neuropsychological assessment. Study Supported by: This research was supported by funding from the Epilepsy Foundation, ID: 336343 Disclosure: Dr. Oyegbile has nothing to disclose. Dr. VanMeter has nothing to disclose. Dr. Gaillard has received personal compensation in an editorial capacity for associate editor epilepsia. Dr. Gaillard holds stock and/or stock options in Pfizer (13,200), Siemens (21,300), General Electric (97,000, estate Allen Van Tine Gaillard)., which sponsored research in which Dr. Gaillard was involved as an investigator. Dr. Gaillard has received research support from NIH, PERF,. Dr. Hermann has nothing to disclose." @default.
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- W2901688693 date "2018-04-10" @default.
- W2901688693 modified "2023-09-27" @default.
- W2901688693 title "Frontal Lobe Functions in Children with Newly Diagnosed Temporal Lobe Epilepsy: Functional Magnetic Resonance Imaging (P3.287)" @default.
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