Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901708082> ?p ?o ?g. }
- W2901708082 abstract "The long-term success of dental implants is established by literature. Although clinically well defined, the complex genetic pathways underlying osseointegration have not yet been fully elucidated. Furthermore, patients with osteopenia/osteoporosis are considered to present as higher risk for implant failure. Porous tantalum trabecular metal (PTTM), an open-cell porous biomaterial, is suggested to present enhanced biocompatibility and osteoconductivity. The goal of this study was to evaluate the expression patterns of a panel of genes closely associated with osteogenesis and wound healing in osteopenic patients receiving either traditional titanium (Ti) or PTTM cylinders to assess the pathway of genes activation in the early phases of osseointegration.Implant cylinders made of Ti and PTTM were placed in osteopenic volunteers. At 2- and 4 weeks of healing, one Ti and one PTTM cylinder were removed from each subject for RT-PCR analysis using osteogenesis PCR array.Compared to Ti, PTTM-associated bone displayed upregulation of bone matrix proteins, BMP/TGF tisuperfamily, soluble ligand and integrin receptors, growth factors, and collagen genes at one or both time points. Histologically, PTTM implants displayed more robust osteogenesis deposition and maturity when compared to Ti implants from the same patient.Our results indicate that PTTM properties could induce an earlier activation of genes associated with osteogenesis in osteopenic patients suggesting that PTTM implants may attenuate the relative risk of placing dental implants in this population." @default.
- W2901708082 created "2018-11-29" @default.
- W2901708082 creator A5007129874 @default.
- W2901708082 creator A5015664157 @default.
- W2901708082 creator A5016732331 @default.
- W2901708082 creator A5027384981 @default.
- W2901708082 creator A5060915194 @default.
- W2901708082 creator A5063251928 @default.
- W2901708082 creator A5066775807 @default.
- W2901708082 creator A5074924642 @default.
- W2901708082 date "2018-11-23" @default.
- W2901708082 modified "2023-10-18" @default.
- W2901708082 title "Transcriptomic profiling of tantalum metal implant osseointegration in osteopenic patients" @default.
- W2901708082 cites W115107697 @default.
- W2901708082 cites W125852739 @default.
- W2901708082 cites W1532398647 @default.
- W2901708082 cites W1559756705 @default.
- W2901708082 cites W1604203913 @default.
- W2901708082 cites W160845983 @default.
- W2901708082 cites W1800630880 @default.
- W2901708082 cites W1927111502 @default.
- W2901708082 cites W1963633719 @default.
- W2901708082 cites W1971287048 @default.
- W2901708082 cites W1971858811 @default.
- W2901708082 cites W1975821933 @default.
- W2901708082 cites W1978122265 @default.
- W2901708082 cites W1978778471 @default.
- W2901708082 cites W1981614386 @default.
- W2901708082 cites W1985356521 @default.
- W2901708082 cites W1985716862 @default.
- W2901708082 cites W1988331392 @default.
- W2901708082 cites W1992221121 @default.
- W2901708082 cites W1995654353 @default.
- W2901708082 cites W2000123764 @default.
- W2901708082 cites W2006825597 @default.
- W2901708082 cites W2014405464 @default.
- W2901708082 cites W2026072611 @default.
- W2901708082 cites W2039256109 @default.
- W2901708082 cites W2040569119 @default.
- W2901708082 cites W2040645421 @default.
- W2901708082 cites W2048679917 @default.
- W2901708082 cites W2049559529 @default.
- W2901708082 cites W2056825523 @default.
- W2901708082 cites W2056885783 @default.
- W2901708082 cites W2057971375 @default.
- W2901708082 cites W2058628090 @default.
- W2901708082 cites W2063736731 @default.
- W2901708082 cites W2063905029 @default.
- W2901708082 cites W2066052326 @default.
- W2901708082 cites W2069518047 @default.
- W2901708082 cites W2069811152 @default.
- W2901708082 cites W2071780635 @default.
- W2901708082 cites W2072403329 @default.
- W2901708082 cites W2078039754 @default.
- W2901708082 cites W2078948410 @default.
- W2901708082 cites W2079256952 @default.
- W2901708082 cites W2081554679 @default.
- W2901708082 cites W2082417649 @default.
- W2901708082 cites W2083854248 @default.
- W2901708082 cites W2085461582 @default.
- W2901708082 cites W2087173056 @default.
- W2901708082 cites W2088045492 @default.
- W2901708082 cites W2088645454 @default.
- W2901708082 cites W2092073786 @default.
- W2901708082 cites W2095247807 @default.
- W2901708082 cites W2101682146 @default.
- W2901708082 cites W2107277218 @default.
- W2901708082 cites W2107556429 @default.
- W2901708082 cites W2109692680 @default.
- W2901708082 cites W2112581723 @default.
- W2901708082 cites W2112721491 @default.
- W2901708082 cites W2114162483 @default.
- W2901708082 cites W2117841258 @default.
- W2901708082 cites W2120366567 @default.
- W2901708082 cites W2123672254 @default.
- W2901708082 cites W2127048170 @default.
- W2901708082 cites W2127502255 @default.
- W2901708082 cites W2136137131 @default.
- W2901708082 cites W2136823415 @default.
- W2901708082 cites W2137376744 @default.
- W2901708082 cites W2138700890 @default.
- W2901708082 cites W2146122692 @default.
- W2901708082 cites W2146664122 @default.
- W2901708082 cites W2146978818 @default.
- W2901708082 cites W2147060741 @default.
- W2901708082 cites W2147112206 @default.
- W2901708082 cites W2150628622 @default.
- W2901708082 cites W2150743378 @default.
- W2901708082 cites W2151300296 @default.
- W2901708082 cites W2159210886 @default.
- W2901708082 cites W2171504172 @default.
- W2901708082 cites W2172270516 @default.
- W2901708082 cites W2179280333 @default.
- W2901708082 cites W2180599529 @default.
- W2901708082 cites W2192080449 @default.
- W2901708082 cites W2246698452 @default.
- W2901708082 cites W2292815294 @default.
- W2901708082 cites W2325586548 @default.
- W2901708082 cites W2415272057 @default.
- W2901708082 cites W2415792841 @default.