FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901726072> ?p ?o ?g. }

• W2901726072 abstract "Sepsis is a multi-system syndrome that remains the leading cause of mortality and critical illness worldwide, with hemodynamic support being one of the cornerstones of the acute management of sepsis. We used an ovine model of endotoxemic shock to determine if 0.9% saline resuscitation contributes to lung inflammation and injury in acute respiratory distress syndrome, which is a common complication of sepsis, and investigated the potential role of matrix metalloproteinases in this process.Endotoxemic shock was induced in sheep by administration of an escalating dose of lipopolysaccharide, after which they subsequently received either no fluid bolus resuscitation or a 0.9% saline bolus. Lung tissue, bronchoalveolar fluid (BAL) and plasma were analysed by real-time PCR, ELISA, flow cytometry and immunohistochemical staining to assess inflammatory cells, cytokines, hyaluronan and matrix metalloproteinases.Endotoxemia was associated with decreased serum albumin and total protein levels, with activated neutrophils, while the glycocalyx glycosaminoglycan hyaluronan was significantly increased in BAL. Quantitative real-time PCR studies showed higher expression of IL-6 and IL-8 with saline resuscitation but no difference in matrix metalloproteinase expression. BAL and tissue homogenate levels of IL-6, IL-8 and IL-1β were elevated.This data shows that the inflammatory response is enhanced when a host with endotoxemia is resuscitated with saline, with a comparatively higher release of inflammatory cytokines and endothelial/glycocalyx damage, but no change in matrix metalloproteinase levels." @default.
• W2901726072 created "2018-11-29" @default.
• W2901726072 creator A5004994976 @default.
• W2901726072 creator A5005645647 @default.
• W2901726072 creator A5017751218 @default.
• W2901726072 creator A5019747495 @default.
• W2901726072 creator A5022283602 @default.
• W2901726072 creator A5037857502 @default.
• W2901726072 creator A5039138781 @default.
• W2901726072 creator A5039887789 @default.
• W2901726072 creator A5042729842 @default.
• W2901726072 creator A5044167903 @default.
• W2901726072 creator A5049464367 @default.
• W2901726072 creator A5050469350 @default.
• W2901726072 creator A5050826666 @default.
• W2901726072 creator A5054635961 @default.
• W2901726072 creator A5059498904 @default.
• W2901726072 creator A5061930534 @default.
• W2901726072 creator A5066340807 @default.
• W2901726072 creator A5073925816 @default.
• W2901726072 creator A5088613675 @default.
• W2901726072 creator A5089196380 @default.
• W2901726072 date "2018-11-22" @default.
• W2901726072 modified "2023-10-17" @default.
• W2901726072 title "Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock" @default.
• W2901726072 cites W1545521314 @default.
• W2901726072 cites W168341069 @default.
• W2901726072 cites W1769897129 @default.
• W2901726072 cites W1852399084 @default.
• W2901726072 cites W1877315027 @default.
• W2901726072 cites W1981975315 @default.
• W2901726072 cites W1993026721 @default.
• W2901726072 cites W1994334062 @default.
• W2901726072 cites W1994868010 @default.
• W2901726072 cites W2001040760 @default.
• W2901726072 cites W2023970722 @default.
• W2901726072 cites W2027415934 @default.
• W2901726072 cites W2028873933 @default.
• W2901726072 cites W2037516773 @default.
• W2901726072 cites W2041445446 @default.
• W2901726072 cites W2049857242 @default.
• W2901726072 cites W2065451944 @default.
• W2901726072 cites W2071359561 @default.
• W2901726072 cites W2077598713 @default.
• W2901726072 cites W2086412653 @default.
• W2901726072 cites W2088016032 @default.
• W2901726072 cites W2093816949 @default.
• W2901726072 cites W2096883458 @default.
• W2901726072 cites W2097036700 @default.
• W2901726072 cites W2097812456 @default.
• W2901726072 cites W2109728419 @default.
• W2901726072 cites W2112874194 @default.
• W2901726072 cites W2115000187 @default.
• W2901726072 cites W2135400753 @default.
• W2901726072 cites W2139147914 @default.
• W2901726072 cites W2145454934 @default.
• W2901726072 cites W2148788956 @default.
• W2901726072 cites W2156715637 @default.
• W2901726072 cites W2280404143 @default.
• W2901726072 cites W2287692495 @default.
• W2901726072 cites W2314787815 @default.
• W2901726072 cites W2335526311 @default.
• W2901726072 cites W2402787830 @default.
• W2901726072 cites W2615307041 @default.
• W2901726072 cites W2806678077 @default.
• W2901726072 cites W4376453108 @default.
• W2901726072 cites W781671099 @default.
• W2901726072 cites W2579350775 @default.
• W2901726072 doi "https://doi.org/10.1186/s12931-018-0935-4" @default.
• W2901726072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6249903" @default.
• W2901726072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30466423" @default.
• W2901726072 hasPublicationYear "2018" @default.
• W2901726072 type Work @default.
• W2901726072 sameAs 2901726072 @default.
• W2901726072 citedByCount "19" @default.
• W2901726072 countsByYear W29017260722019 @default.
• W2901726072 countsByYear W29017260722021 @default.
• W2901726072 countsByYear W29017260722022 @default.
• W2901726072 countsByYear W29017260722023 @default.
• W2901726072 crossrefType "journal-article" @default.
• W2901726072 hasAuthorship W2901726072A5004994976 @default.
• W2901726072 hasAuthorship W2901726072A5005645647 @default.
• W2901726072 hasAuthorship W2901726072A5017751218 @default.
• W2901726072 hasAuthorship W2901726072A5019747495 @default.
• W2901726072 hasAuthorship W2901726072A5022283602 @default.
• W2901726072 hasAuthorship W2901726072A5037857502 @default.
• W2901726072 hasAuthorship W2901726072A5039138781 @default.
• W2901726072 hasAuthorship W2901726072A5039887789 @default.
• W2901726072 hasAuthorship W2901726072A5042729842 @default.
• W2901726072 hasAuthorship W2901726072A5044167903 @default.
• W2901726072 hasAuthorship W2901726072A5049464367 @default.
• W2901726072 hasAuthorship W2901726072A5050469350 @default.
• W2901726072 hasAuthorship W2901726072A5050826666 @default.
• W2901726072 hasAuthorship W2901726072A5054635961 @default.
• W2901726072 hasAuthorship W2901726072A5059498904 @default.
• W2901726072 hasAuthorship W2901726072A5061930534 @default.
• W2901726072 hasAuthorship W2901726072A5066340807 @default.
• W2901726072 hasAuthorship W2901726072A5073925816 @default.
• W2901726072 hasAuthorship W2901726072A5088613675 @default.
• W2901726072 hasAuthorship W2901726072A5089196380 @default.

• next