Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901741449> ?p ?o ?g. }
- W2901741449 endingPage "3093" @default.
- W2901741449 startingPage "3075" @default.
- W2901741449 abstract "Cancer-associated fibroblasts (CAFs) are highly prominent in breast tumors, but their functional heterogeneity and origin are still largely unresolved. We report that bone marrow (BM)–derived mesenchymal stromal cells (MSCs) are recruited to primary breast tumors and to lung metastases and differentiate to a distinct subpopulation of CAFs. We show that BM-derived CAFs are functionally important for tumor growth and enhance angiogenesis via up-regulation of Clusterin. Using newly generated transgenic mice and adoptive BM transplantations, we demonstrate that BM-derived fibroblasts are a substantial source of CAFs in the tumor microenvironment. Unlike resident CAFs, BM-derived CAFs do not express PDGFRα, and their recruitment resulted in a decrease in the percentage of PDGFRα-expressing CAFs. Strikingly, decrease in PDGFRα in breast cancer patients was associated with worse prognosis, suggesting that BM-derived CAFs may have deleterious effects on survival. Therefore, PDGFRα expression distinguishes two functionally unique CAF populations in breast tumors and metastases and may have important implications for patient stratification and precision therapeutics." @default.
- W2901741449 created "2018-11-29" @default.
- W2901741449 creator A5008169267 @default.
- W2901741449 creator A5014313085 @default.
- W2901741449 creator A5021648941 @default.
- W2901741449 creator A5029858514 @default.
- W2901741449 creator A5040082843 @default.
- W2901741449 creator A5041516680 @default.
- W2901741449 creator A5045030798 @default.
- W2901741449 creator A5052545062 @default.
- W2901741449 creator A5056770960 @default.
- W2901741449 creator A5059302541 @default.
- W2901741449 creator A5073033099 @default.
- W2901741449 creator A5074717453 @default.
- W2901741449 date "2018-11-23" @default.
- W2901741449 modified "2023-10-15" @default.
- W2901741449 title "Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer" @default.
- W2901741449 cites W1487373628 @default.
- W2901741449 cites W1571628027 @default.
- W2901741449 cites W1585505607 @default.
- W2901741449 cites W1617495083 @default.
- W2901741449 cites W1904692756 @default.
- W2901741449 cites W1965691956 @default.
- W2901741449 cites W1968650422 @default.
- W2901741449 cites W1978099625 @default.
- W2901741449 cites W1986995465 @default.
- W2901741449 cites W1991719268 @default.
- W2901741449 cites W2006196877 @default.
- W2901741449 cites W2008104067 @default.
- W2901741449 cites W2012034410 @default.
- W2901741449 cites W2044339772 @default.
- W2901741449 cites W2049258429 @default.
- W2901741449 cites W2052092179 @default.
- W2901741449 cites W2053101826 @default.
- W2901741449 cites W2062809449 @default.
- W2901741449 cites W2063249586 @default.
- W2901741449 cites W2063405902 @default.
- W2901741449 cites W2064225313 @default.
- W2901741449 cites W2068009696 @default.
- W2901741449 cites W2075465677 @default.
- W2901741449 cites W2076838198 @default.
- W2901741449 cites W2076891934 @default.
- W2901741449 cites W2076971387 @default.
- W2901741449 cites W2077446789 @default.
- W2901741449 cites W2093172278 @default.
- W2901741449 cites W2093804120 @default.
- W2901741449 cites W2096047971 @default.
- W2901741449 cites W2100303404 @default.
- W2901741449 cites W2102729369 @default.
- W2901741449 cites W2107872506 @default.
- W2901741449 cites W2110957241 @default.
- W2901741449 cites W2112507699 @default.
- W2901741449 cites W2115189949 @default.
- W2901741449 cites W2122914905 @default.
- W2901741449 cites W2138831748 @default.
- W2901741449 cites W2139788242 @default.
- W2901741449 cites W2141815918 @default.
- W2901741449 cites W2142530756 @default.
- W2901741449 cites W2143001097 @default.
- W2901741449 cites W2143820626 @default.
- W2901741449 cites W2146749615 @default.
- W2901741449 cites W2155412740 @default.
- W2901741449 cites W2157142589 @default.
- W2901741449 cites W2160108544 @default.
- W2901741449 cites W2160609918 @default.
- W2901741449 cites W2161214210 @default.
- W2901741449 cites W2163807830 @default.
- W2901741449 cites W2168631000 @default.
- W2901741449 cites W2169281418 @default.
- W2901741449 cites W2170866914 @default.
- W2901741449 cites W2189406882 @default.
- W2901741449 cites W2347175105 @default.
- W2901741449 cites W2442704894 @default.
- W2901741449 cites W2443870287 @default.
- W2901741449 cites W2476542314 @default.
- W2901741449 cites W2512899508 @default.
- W2901741449 cites W2525107653 @default.
- W2901741449 cites W2541492211 @default.
- W2901741449 cites W2605141165 @default.
- W2901741449 cites W2749802773 @default.
- W2901741449 cites W2760162359 @default.
- W2901741449 cites W2762323160 @default.
- W2901741449 doi "https://doi.org/10.1084/jem.20180818" @default.
- W2901741449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6279405" @default.
- W2901741449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30470719" @default.
- W2901741449 hasPublicationYear "2018" @default.
- W2901741449 type Work @default.
- W2901741449 sameAs 2901741449 @default.
- W2901741449 citedByCount "177" @default.
- W2901741449 countsByYear W29017414492018 @default.
- W2901741449 countsByYear W29017414492019 @default.
- W2901741449 countsByYear W29017414492020 @default.
- W2901741449 countsByYear W29017414492021 @default.
- W2901741449 countsByYear W29017414492022 @default.
- W2901741449 countsByYear W29017414492023 @default.
- W2901741449 crossrefType "journal-article" @default.
- W2901741449 hasAuthorship W2901741449A5008169267 @default.
- W2901741449 hasAuthorship W2901741449A5014313085 @default.