Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901756091> ?p ?o ?g. }
- W2901756091 endingPage "335" @default.
- W2901756091 startingPage "323" @default.
- W2901756091 abstract "Meters of DNA wrap around histone proteins to form nucleosomes and fit inside the micron-diameter nucleus. For the genetic information encoded in the DNA to become available for transcription, replication, and repair, the DNA-histone assembly must be disrupted. Experiment has indicated that the outer stretches of nucleosomal DNA breathe by spontaneously detaching from and reattaching to the histone core. Here, we report direct observation of spontaneous DNA breathing in atomistic molecular dynamics simulations, detailing a microscopic mechanism of the DNA breathing process. According to our simulations, the outer stretches of nucleosomal DNA detach in discrete steps involving 5 or 10 base pairs, with the detachment process being orchestrated by the motion of several conserved histone residues. The inner stretches of nucleosomal DNA are found to be more stably associated with the histone core by more abundant nonspecific DNA-protein contacts, providing a microscopic interpretation of nucleosome unraveling experiments. The CG content of nucleosomal DNA is found to anticorrelate with the extent of unwrapping, supporting the possibility that AT-rich segments may signal the start of transcription by forming less stable nucleosomes." @default.
- W2901756091 created "2018-11-29" @default.
- W2901756091 creator A5076175038 @default.
- W2901756091 creator A5081401368 @default.
- W2901756091 date "2019-01-01" @default.
- W2901756091 modified "2023-10-10" @default.
- W2901756091 title "Molecular Mechanism of Spontaneous Nucleosome Unraveling" @default.
- W2901756091 cites W1031578623 @default.
- W2901756091 cites W1564217760 @default.
- W2901756091 cites W1608797052 @default.
- W2901756091 cites W1946633197 @default.
- W2901756091 cites W1969263578 @default.
- W2901756091 cites W1972758026 @default.
- W2901756091 cites W1976499671 @default.
- W2901756091 cites W1978979339 @default.
- W2901756091 cites W1981050748 @default.
- W2901756091 cites W1981225934 @default.
- W2901756091 cites W1981962803 @default.
- W2901756091 cites W1984762771 @default.
- W2901756091 cites W1985383327 @default.
- W2901756091 cites W1987162338 @default.
- W2901756091 cites W1988997227 @default.
- W2901756091 cites W1991794210 @default.
- W2901756091 cites W2002376004 @default.
- W2901756091 cites W2005450410 @default.
- W2901756091 cites W2006855885 @default.
- W2901756091 cites W2007765298 @default.
- W2901756091 cites W2008656832 @default.
- W2901756091 cites W2015029046 @default.
- W2901756091 cites W2017196167 @default.
- W2901756091 cites W2018097663 @default.
- W2901756091 cites W2020884463 @default.
- W2901756091 cites W2021722016 @default.
- W2901756091 cites W2022772618 @default.
- W2901756091 cites W2024857462 @default.
- W2901756091 cites W2028120697 @default.
- W2901756091 cites W2028263411 @default.
- W2901756091 cites W2029667189 @default.
- W2901756091 cites W2039011578 @default.
- W2901756091 cites W2040193953 @default.
- W2901756091 cites W2049722408 @default.
- W2901756091 cites W2052904236 @default.
- W2901756091 cites W2057216141 @default.
- W2901756091 cites W2057350299 @default.
- W2901756091 cites W2057477511 @default.
- W2901756091 cites W2058874255 @default.
- W2901756091 cites W2061111901 @default.
- W2901756091 cites W2064388657 @default.
- W2901756091 cites W2065571115 @default.
- W2901756091 cites W2067174909 @default.
- W2901756091 cites W2070650525 @default.
- W2901756091 cites W2077547710 @default.
- W2901756091 cites W2079114755 @default.
- W2901756091 cites W2080139629 @default.
- W2901756091 cites W2080569293 @default.
- W2901756091 cites W2081468628 @default.
- W2901756091 cites W2081693079 @default.
- W2901756091 cites W2081800341 @default.
- W2901756091 cites W2084118479 @default.
- W2901756091 cites W2084748297 @default.
- W2901756091 cites W2084868118 @default.
- W2901756091 cites W2087225474 @default.
- W2901756091 cites W2091190427 @default.
- W2901756091 cites W2099343472 @default.
- W2901756091 cites W2102123683 @default.
- W2901756091 cites W2103945336 @default.
- W2901756091 cites W2108636498 @default.
- W2901756091 cites W2111089783 @default.
- W2901756091 cites W2113857452 @default.
- W2901756091 cites W2124618141 @default.
- W2901756091 cites W2127933934 @default.
- W2901756091 cites W2128572087 @default.
- W2901756091 cites W2129314778 @default.
- W2901756091 cites W2129695352 @default.
- W2901756091 cites W2136729627 @default.
- W2901756091 cites W2144792857 @default.
- W2901756091 cites W2151553287 @default.
- W2901756091 cites W2152406248 @default.
- W2901756091 cites W2154109129 @default.
- W2901756091 cites W2154240028 @default.
- W2901756091 cites W2157089275 @default.
- W2901756091 cites W2157222407 @default.
- W2901756091 cites W2162563461 @default.
- W2901756091 cites W2167132427 @default.
- W2901756091 cites W2266595811 @default.
- W2901756091 cites W2316392160 @default.
- W2901756091 cites W2317141545 @default.
- W2901756091 cites W2325642794 @default.
- W2901756091 cites W2329092529 @default.
- W2901756091 cites W2340534477 @default.
- W2901756091 cites W2414650303 @default.
- W2901756091 cites W2416255515 @default.
- W2901756091 cites W2441639196 @default.
- W2901756091 cites W2485301169 @default.
- W2901756091 cites W2495057506 @default.
- W2901756091 cites W2523898334 @default.
- W2901756091 cites W2561226423 @default.
- W2901756091 cites W2563570199 @default.