FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901761663> ?p ?o ?g. }

• W2901761663 endingPage "e0207711" @default.
• W2901761663 startingPage "e0207711" @default.
• W2901761663 abstract "Despite the prevalence of inhalation therapy in the treatment of pediatric respiratory disorders, most prominently asthma, the fraction of inhaled drugs reaching the lungs for maximal efficacy remains adversely low. By and large drug delivery devices and their inhalation guidelines are typically derived from adult studies with child dosages adapted according to body weight. While it has long been recognized that physiological (e.g. airway sizes, breathing maneuvers) and physical transport (e.g. aerosol dynamics) characteristics are critical in governing deposition outcomes, such knowledge has yet to be extensively adapted to younger populations. Motivated by such shortcomings, the present work leverages in a first step in silico computational fluid dynamics (CFD) to explore opportunities for augmenting aerosol deposition in children based on respiratory physiological and physical transport determinants. Using an idealized, anatomically-faithful upper airway geometry, airflow and aerosol motion are simulated as a function of age, spanning a five year old to an adult. Breathing conditions mimic realistic age-specific inhalation maneuvers representative of Dry Powder Inhalers (DPI) and nebulizer inhalation. Our findings point to the existence of a single dimensionless curve governing deposition in the conductive airways via the dimensionless Stokes number (Stk). Most significantly, we uncover the existence of a distinct deposition peak irrespective of age. For the DPI simulations, this peak (∼ 80%) occurs at Stk ≈ 0.06 whereas for nebulizer simulations, the corresponding peak (∼ 45%) occurs in the range of Stk between 0.03-0.04. Such dimensionless findings hence translate to an optimal window of micron-sized aerosols that evolves with age and varies with inhalation device. The existence of such deposition optima advocates revisiting design guidelines for optimizing deposition outcomes in pediatric inhalation therapy." @default.
• W2901761663 created "2018-11-29" @default.
• W2901761663 creator A5029172221 @default.
• W2901761663 creator A5045190191 @default.
• W2901761663 creator A5048430194 @default.
• W2901761663 creator A5052676561 @default.
• W2901761663 creator A5071131673 @default.
• W2901761663 date "2018-11-20" @default.
• W2901761663 modified "2023-10-14" @default.
• W2901761663 title "Targeting inhaled aerosol delivery to upper airways in children: Insight from computational fluid dynamics (CFD)" @default.
• W2901761663 cites W1507490315 @default.
• W2901761663 cites W1942329753 @default.
• W2901761663 cites W1967026734 @default.
• W2901761663 cites W1974640020 @default.
• W2901761663 cites W1976628115 @default.
• W2901761663 cites W1986522976 @default.
• W2901761663 cites W1988978734 @default.
• W2901761663 cites W1991968623 @default.
• W2901761663 cites W1993193134 @default.
• W2901761663 cites W1998319112 @default.
• W2901761663 cites W1998792586 @default.
• W2901761663 cites W2004803270 @default.
• W2901761663 cites W2005856267 @default.
• W2901761663 cites W2008624656 @default.
• W2901761663 cites W2008918656 @default.
• W2901761663 cites W2011588065 @default.
• W2901761663 cites W2014595029 @default.
• W2901761663 cites W2016181188 @default.
• W2901761663 cites W2020462662 @default.
• W2901761663 cites W2022405720 @default.
• W2901761663 cites W2022441342 @default.
• W2901761663 cites W2025018153 @default.
• W2901761663 cites W2025531712 @default.
• W2901761663 cites W2026472533 @default.
• W2901761663 cites W2030213676 @default.
• W2901761663 cites W2037595863 @default.
• W2901761663 cites W2038526590 @default.
• W2901761663 cites W2038703846 @default.
• W2901761663 cites W2039206076 @default.
• W2901761663 cites W2039888688 @default.
• W2901761663 cites W2042235230 @default.
• W2901761663 cites W2046256563 @default.
• W2901761663 cites W2046370810 @default.
• W2901761663 cites W2052109061 @default.
• W2901761663 cites W2059681146 @default.
• W2901761663 cites W2061514443 @default.
• W2901761663 cites W2063725191 @default.
• W2901761663 cites W2064323811 @default.
• W2901761663 cites W2069321448 @default.
• W2901761663 cites W2071588037 @default.
• W2901761663 cites W2073266737 @default.
• W2901761663 cites W2078671329 @default.
• W2901761663 cites W2081979876 @default.
• W2901761663 cites W2086170438 @default.
• W2901761663 cites W2087783100 @default.
• W2901761663 cites W2093146297 @default.
• W2901761663 cites W2097534845 @default.
• W2901761663 cites W2100263089 @default.
• W2901761663 cites W2101909755 @default.
• W2901761663 cites W2108175690 @default.
• W2901761663 cites W2108943436 @default.
• W2901761663 cites W2115229157 @default.
• W2901761663 cites W2116014377 @default.
• W2901761663 cites W2130124185 @default.
• W2901761663 cites W2132424246 @default.
• W2901761663 cites W2132858909 @default.
• W2901761663 cites W2132916726 @default.
• W2901761663 cites W2140718395 @default.
• W2901761663 cites W2142167741 @default.
• W2901761663 cites W2143585992 @default.
• W2901761663 cites W2149818536 @default.
• W2901761663 cites W2152837630 @default.
• W2901761663 cites W2165436165 @default.
• W2901761663 cites W2170130633 @default.
• W2901761663 cites W2172012864 @default.
• W2901761663 cites W2174025193 @default.
• W2901761663 cites W2179924016 @default.
• W2901761663 cites W2212214068 @default.
• W2901761663 cites W2230519420 @default.
• W2901761663 cites W2255415998 @default.
• W2901761663 cites W2281689438 @default.
• W2901761663 cites W2460976003 @default.
• W2901761663 cites W2487604334 @default.
• W2901761663 cites W2517190534 @default.
• W2901761663 cites W2520934308 @default.
• W2901761663 cites W2530735078 @default.
• W2901761663 cites W2751774187 @default.
• W2901761663 cites W2753673201 @default.
• W2901761663 cites W2763883500 @default.
• W2901761663 cites W2775027552 @default.
• W2901761663 cites W2777139155 @default.
• W2901761663 cites W2799328229 @default.
• W2901761663 cites W4213189266 @default.
• W2901761663 cites W4238406112 @default.
• W2901761663 doi "https://doi.org/10.1371/journal.pone.0207711" @default.
• W2901761663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6245749" @default.
• W2901761663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30458054" @default.
• W2901761663 hasPublicationYear "2018" @default.

• next