Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901763103> ?p ?o ?g. }
- W2901763103 abstract "The oncogene HDAC6 controls numerous cell processes that are related to tumorigenesis and metastasis, and has recently arisen as a target to treat malignancies. The ERK cascade is a classic pathway driving oncogenesis, and the components of this pathway are either highly mutated in cancers or are vital in cancer's pathological activity. The interactions between these important components of tumor proliferation have been examined, and our research has demonstrated that they regulate each other as evidenced by different posttranslational modifications. Preclinical evidence also supports clinical trials cotargeting these two pathways, which may provide better efficacy than single treatment. Furthermore, HDAC6 and ERK both participate in the regulation of T cell maturation and may have implications on the functions of immune cells. This leads to the possibility of connecting HDAC6 and ERK to immunotherapy. In this review, we summarize the published studies about the interaction of HDAC6 and ERK cascade and their relationship to cancers. We also include the association of HDAC6 and ERK to immune system and discuss the plausibility of linking these to immunotherapy." @default.
- W2901763103 created "2018-11-29" @default.
- W2901763103 creator A5019233978 @default.
- W2901763103 creator A5031079074 @default.
- W2901763103 creator A5038600573 @default.
- W2901763103 creator A5053431676 @default.
- W2901763103 creator A5061627280 @default.
- W2901763103 creator A5070520673 @default.
- W2901763103 creator A5075033525 @default.
- W2901763103 creator A5086340080 @default.
- W2901763103 date "2018-05-01" @default.
- W2901763103 modified "2023-10-16" @default.
- W2901763103 title "Implications of the HDAC6-ERK1 feed forward loop in immunotherapy" @default.
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