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• W2901766985 abstract "An extraordinary binding site generated in heparan sulfate (HS) structures, during its biosynthesis, provides a unique opportunity to interact with multiple protein ligands including viral proteins, and therefore adds tremendous value to this master molecule. An example of such a moiety is the sulfation at the C3 position of glucosamine residues in HS chain via 3-O sulfotransferase (3-OST) enzymes, which generates a unique virus-cell fusion receptor during herpes simplex virus (HSV) entry and spread. Emerging evidence now suggests that the unique patterns in HS sulfation assist multiple viruses in invading host cells at various steps of their life cycles. In addition, sulfated-HS structures are known to assist in invading host defense mechanisms and initiating multiple inflammatory processes; a critical event in the disease development. All these processes are detrimental for the host and therefore raise the question of how HS-sulfation is regulated. Epigenetic modulations have been shown to be implicated in these reactions during HSV infection as well as in HS modifying enzyme sulfotransferases, and therefore pose a critical component in answering it. Interestingly, heparanase (HPSE) activity is shown to be upregulated during virus infection and multiple other diseases assisting in virus replication to promote cell and tissue damage. These phenomena suggest that sulfotransferases and HPSE serve as key players in extracellular matrix remodeling and possibly generating unique signatures in a given disease. Therefore, identifying the epigenetic regulation of OST genes, and HPSE resulting in altered yet specific sulfation patterns in HS chain during virus infection, will be a significant a step toward developing potential diagnostic markers and designing novel therapies." @default.
• W2901766985 created "2018-11-29" @default.
• W2901766985 creator A5023333258 @default.
• W2901766985 creator A5041710956 @default.
• W2901766985 creator A5065970650 @default.
• W2901766985 creator A5074022590 @default.
• W2901766985 creator A5086095686 @default.
• W2901766985 creator A5087271584 @default.
• W2901766985 creator A5090507139 @default.
• W2901766985 date "2018-11-22" @default.
• W2901766985 modified "2023-09-27" @default.
• W2901766985 title "Sulfotransferase and Heparanase: Remodeling Engines in Promoting Virus Infection and Disease Development" @default.
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