FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901767534> ?p ?o ?g. }

• W2901767534 endingPage "328" @default.
• W2901767534 startingPage "321" @default.
• W2901767534 abstract "Background There is persistent uncertainty over the benefits of early intensive systolic blood pressure lowering in acute intracerebral hemorrhage. In particular, over the timing, target, and intensity of systolic blood pressure control for optimum balance of potential benefits (i.e. functional recovery) and risks (e.g. cerebral ischemia). Aims To determine associations of early systolic blood pressure lowering parameters and outcomes in patients with a hypertensive response in acute intracerebral hemorrhage. Secondary aims are to identify the modifying effects of patient characteristics and an optimal systolic blood pressure lowering profile. Methods Individual participant data pooled analyses of two large, multicenter, randomized controlled trials specifically undertaken to assess the effects of early intensive systolic blood pressure reduction on clinical outcomes in acute intracerebral hemorrhage: the Intensive Blood Pressure in Acute Intracerebral Hemorrhage Trial (INTERACT2) and the Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH-II) trial. Combined data will include baseline characteristics; systolic blood pressure in the first 24 h; process of care measures; and key efficacy and safety outcomes. Outcomes The primary outcome is functional recovery, defined by an ordinal distribution of scores on the modified Rankin scale at 90 days post-randomization. Secondary outcomes include various standard binary cut-points for disability-free survival on the modified Rankin scale, and health-related quality of life at 90 days. Safety outcomes include symptomatic hypotension requiring corrective therapy and early neurologic deterioration within 24 h, and deaths, any serious adverse event, and cardiac and renal serious adverse events, within 90 days. Discussion A pre-determined protocol was developed to facilitate successful collaboration and reduce analysis bias arising from prior knowledge of the findings. Clinical trial registration URL: http://www.clinicaltrials.gov . Unique identifiers for INTERACT2 (NCT00716079) and ATACH-II (NCT01176565)." @default.
• W2901767534 created "2018-11-29" @default.
• W2901767534 creator A5002815959 @default.
• W2901767534 creator A5005538880 @default.
• W2901767534 creator A5018995296 @default.
• W2901767534 creator A5025167498 @default.
• W2901767534 creator A5036895407 @default.
• W2901767534 creator A5074193993 @default.
• W2901767534 creator A5082747274 @default.
• W2901767534 date "2018-11-12" @default.
• W2901767534 modified "2023-10-17" @default.
• W2901767534 title "Statistical analysis plan for pooled individual patient data from two landmark randomized trials (INTERACT2 and ATACH-II) of intensive blood pressure lowering treatment in acute intracerebral hemorrhage" @default.
• W2901767534 cites W1893102940 @default.
• W2901767534 cites W1988985184 @default.
• W2901767534 cites W2008889136 @default.
• W2901767534 cites W2029584540 @default.
• W2901767534 cites W2056498577 @default.
• W2901767534 cites W2114214167 @default.
• W2901767534 cites W2115637271 @default.
• W2901767534 cites W2147048340 @default.
• W2901767534 cites W2171672167 @default.
• W2901767534 cites W2346338869 @default.
• W2901767534 cites W2409181187 @default.
• W2901767534 cites W2587958845 @default.
• W2901767534 cites W2593032758 @default.
• W2901767534 cites W2752488213 @default.
• W2901767534 cites W2766508408 @default.
• W2901767534 cites W2781811119 @default.
• W2901767534 doi "https://doi.org/10.1177/1747493018813695" @default.
• W2901767534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30418098" @default.
• W2901767534 hasPublicationYear "2018" @default.
• W2901767534 type Work @default.
• W2901767534 sameAs 2901767534 @default.
• W2901767534 citedByCount "7" @default.
• W2901767534 countsByYear W29017675342020 @default.
• W2901767534 countsByYear W29017675342022 @default.
• W2901767534 countsByYear W29017675342023 @default.
• W2901767534 crossrefType "journal-article" @default.
• W2901767534 hasAuthorship W2901767534A5002815959 @default.
• W2901767534 hasAuthorship W2901767534A5005538880 @default.
• W2901767534 hasAuthorship W2901767534A5018995296 @default.
• W2901767534 hasAuthorship W2901767534A5025167498 @default.
• W2901767534 hasAuthorship W2901767534A5036895407 @default.
• W2901767534 hasAuthorship W2901767534A5074193993 @default.
• W2901767534 hasAuthorship W2901767534A5082747274 @default.
• W2901767534 hasConcept C126322002 @default.
• W2901767534 hasConcept C127413603 @default.
• W2901767534 hasConcept C164705383 @default.
• W2901767534 hasConcept C168563851 @default.
• W2901767534 hasConcept C17624336 @default.
• W2901767534 hasConcept C177713679 @default.
• W2901767534 hasConcept C194828623 @default.
• W2901767534 hasConcept C197934379 @default.
• W2901767534 hasConcept C2777094939 @default.
• W2901767534 hasConcept C2780645631 @default.
• W2901767534 hasConcept C2780931571 @default.
• W2901767534 hasConcept C3020199598 @default.
• W2901767534 hasConcept C42219234 @default.
• W2901767534 hasConcept C541997718 @default.
• W2901767534 hasConcept C71924100 @default.
• W2901767534 hasConcept C78519656 @default.
• W2901767534 hasConcept C84393581 @default.
• W2901767534 hasConceptScore W2901767534C126322002 @default.
• W2901767534 hasConceptScore W2901767534C127413603 @default.
• W2901767534 hasConceptScore W2901767534C164705383 @default.
• W2901767534 hasConceptScore W2901767534C168563851 @default.
• W2901767534 hasConceptScore W2901767534C17624336 @default.
• W2901767534 hasConceptScore W2901767534C177713679 @default.
• W2901767534 hasConceptScore W2901767534C194828623 @default.
• W2901767534 hasConceptScore W2901767534C197934379 @default.
• W2901767534 hasConceptScore W2901767534C2777094939 @default.
• W2901767534 hasConceptScore W2901767534C2780645631 @default.
• W2901767534 hasConceptScore W2901767534C2780931571 @default.
• W2901767534 hasConceptScore W2901767534C3020199598 @default.
• W2901767534 hasConceptScore W2901767534C42219234 @default.
• W2901767534 hasConceptScore W2901767534C541997718 @default.
• W2901767534 hasConceptScore W2901767534C71924100 @default.
• W2901767534 hasConceptScore W2901767534C78519656 @default.
• W2901767534 hasConceptScore W2901767534C84393581 @default.
• W2901767534 hasFunder F4320334705 @default.
• W2901767534 hasFunder F4320337359 @default.
• W2901767534 hasIssue "3" @default.
• W2901767534 hasLocation W29017675341 @default.
• W2901767534 hasOpenAccess W2901767534 @default.
• W2901767534 hasPrimaryLocation W29017675341 @default.
• W2901767534 hasRelatedWork W2110918252 @default.
• W2901767534 hasRelatedWork W2139750291 @default.
• W2901767534 hasRelatedWork W2139922741 @default.
• W2901767534 hasRelatedWork W2160454231 @default.
• W2901767534 hasRelatedWork W2273129695 @default.
• W2901767534 hasRelatedWork W2363255808 @default.
• W2901767534 hasRelatedWork W2890068932 @default.
• W2901767534 hasRelatedWork W3142677510 @default.
• W2901767534 hasRelatedWork W3151283227 @default.
• W2901767534 hasRelatedWork W4224280838 @default.
• W2901767534 hasVolume "14" @default.
• W2901767534 isParatext "false" @default.
• W2901767534 isRetracted "false" @default.

• next