FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901798378> ?p ?o ?g. }

• W2901798378 endingPage "143" @default.
• W2901798378 startingPage "134" @default.
• W2901798378 abstract "Interferon α (IFNα) so far is the only therapeutic option for chronic hepatitis B virus (HBV) infection that can lead to virus clearance. Unfortunately, its application is limited by side effects and response rates are low. The aim of this study was to generate a novel long-acting IFNα with the help of PASylation technology that adds a polypeptide comprising Proline, Alanine and Serine (PAS) to increase plasma half-life. Following evaluation of four selected recombinant murine IFNα (mIFNα) subtypes in cell culture, the most active subtype, mIFNα11, was fused with a 600 amino acid PAS chain. The activity of PAS-mIFNα was assessed by interferon bioassay and further evaluated for induction of interferon-stimulated genes (ISG) and antiviral efficacy in cell culture as well as in HBV-transgenic mice. PAS-mIFNα induced expression of ISG comparable to unmodified mIFNα and, likewise, evoked dose-dependent reduction of HBV replication in vitro. In vivo, PAS-mIFNα led to pronounced suppression of HBV replication without detectable liver damage whereas conventional mIFNα treatment only had a modest antiviral effect. Importantly, all PAS-mIFNα treated mice showed an anti-HBs antibody response, lost HBsAg and achieved seroconversion after three weeks. PASylated IFNα showed a profoundly increased antiviral effect in vivo compared to the non-modified version without toxicity, providing proof-of-concept that an improved IFNα can achieve higher rates of HBV antiviral and immune control." @default.
• W2901798378 created "2018-11-29" @default.
• W2901798378 creator A5010432172 @default.
• W2901798378 creator A5016243200 @default.
• W2901798378 creator A5018469284 @default.
• W2901798378 creator A5022155277 @default.
• W2901798378 creator A5038456446 @default.
• W2901798378 creator A5040016555 @default.
• W2901798378 creator A5043515383 @default.
• W2901798378 creator A5052121433 @default.
• W2901798378 creator A5054375555 @default.
• W2901798378 creator A5070530041 @default.
• W2901798378 creator A5073836849 @default.
• W2901798378 creator A5089752592 @default.
• W2901798378 date "2019-01-01" @default.
• W2901798378 modified "2023-10-18" @default.
• W2901798378 title "PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice" @default.
• W2901798378 cites W1514154332 @default.
• W2901798378 cites W1540878706 @default.
• W2901798378 cites W1799137450 @default.
• W2901798378 cites W1918954877 @default.
• W2901798378 cites W1950099322 @default.
• W2901798378 cites W1967475015 @default.
• W2901798378 cites W1984349476 @default.
• W2901798378 cites W1995488467 @default.
• W2901798378 cites W2011308270 @default.
• W2901798378 cites W2013039788 @default.
• W2901798378 cites W2014374827 @default.
• W2901798378 cites W2015763479 @default.
• W2901798378 cites W2019472095 @default.
• W2901798378 cites W2026036608 @default.
• W2901798378 cites W2040653543 @default.
• W2901798378 cites W2047188856 @default.
• W2901798378 cites W2047468814 @default.
• W2901798378 cites W2051173965 @default.
• W2901798378 cites W2052242127 @default.
• W2901798378 cites W2062343812 @default.
• W2901798378 cites W2066279181 @default.
• W2901798378 cites W2066680692 @default.
• W2901798378 cites W2067919074 @default.
• W2901798378 cites W2073526502 @default.
• W2901798378 cites W2092554625 @default.
• W2901798378 cites W2096828550 @default.
• W2901798378 cites W2101273158 @default.
• W2901798378 cites W2115528382 @default.
• W2901798378 cites W2115677357 @default.
• W2901798378 cites W2119387393 @default.
• W2901798378 cites W2120426460 @default.
• W2901798378 cites W2139926695 @default.
• W2901798378 cites W2161892929 @default.
• W2901798378 cites W2169631718 @default.
• W2901798378 cites W2316569370 @default.
• W2901798378 cites W2419632689 @default.
• W2901798378 cites W2424031828 @default.
• W2901798378 cites W2535870561 @default.
• W2901798378 cites W2541628542 @default.
• W2901798378 cites W2594710582 @default.
• W2901798378 cites W2595248089 @default.
• W2901798378 cites W2727454415 @default.
• W2901798378 cites W2739640246 @default.
• W2901798378 cites W2801666689 @default.
• W2901798378 doi "https://doi.org/10.1016/j.antiviral.2018.11.003" @default.
• W2901798378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30439382" @default.
• W2901798378 hasPublicationYear "2019" @default.
• W2901798378 type Work @default.
• W2901798378 sameAs 2901798378 @default.
• W2901798378 citedByCount "20" @default.
• W2901798378 countsByYear W29017983782019 @default.
• W2901798378 countsByYear W29017983782020 @default.
• W2901798378 countsByYear W29017983782021 @default.
• W2901798378 countsByYear W29017983782022 @default.
• W2901798378 countsByYear W29017983782023 @default.
• W2901798378 crossrefType "journal-article" @default.
• W2901798378 hasAuthorship W2901798378A5010432172 @default.
• W2901798378 hasAuthorship W2901798378A5016243200 @default.
• W2901798378 hasAuthorship W2901798378A5018469284 @default.
• W2901798378 hasAuthorship W2901798378A5022155277 @default.
• W2901798378 hasAuthorship W2901798378A5038456446 @default.
• W2901798378 hasAuthorship W2901798378A5040016555 @default.
• W2901798378 hasAuthorship W2901798378A5043515383 @default.
• W2901798378 hasAuthorship W2901798378A5052121433 @default.
• W2901798378 hasAuthorship W2901798378A5054375555 @default.
• W2901798378 hasAuthorship W2901798378A5070530041 @default.
• W2901798378 hasAuthorship W2901798378A5073836849 @default.
• W2901798378 hasAuthorship W2901798378A5089752592 @default.
• W2901798378 hasConcept C150903083 @default.
• W2901798378 hasConcept C159047783 @default.
• W2901798378 hasConcept C207001950 @default.
• W2901798378 hasConcept C2522874641 @default.
• W2901798378 hasConcept C2776178377 @default.
• W2901798378 hasConcept C2777410769 @default.
• W2901798378 hasConcept C2777451964 @default.
• W2901798378 hasConcept C2780593183 @default.
• W2901798378 hasConcept C71924100 @default.
• W2901798378 hasConcept C86803240 @default.
• W2901798378 hasConcept C98274493 @default.
• W2901798378 hasConceptScore W2901798378C150903083 @default.
• W2901798378 hasConceptScore W2901798378C159047783 @default.

• next