FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901806411> ?p ?o ?g. }

• W2901806411 abstract "Thrombogenicity is the predominant obstacle to successful implantation of decellularized spleen matrix (DSM). The aim of this study was to construct a transplantable functional bioartificial liver (BAL) with the use of DSM. This was achieved by layer-by-layer electrostatic immobilization technique by using poly dimethyl diallyl ammonium chloride and heparin. After heparin immobilization, DSM gradually turned from translucent into completely opaque milky white. Toluidine blue staining showed strong positive staining of the entire coated DSM. In vitro diluted blood perfusion test showed that the splenic arterial pressure of the heparin-coated DSM was much lower than that of the non-coated DSM (p < 0.01). Then, we heterotopically transplanted the modified DSM into rat hepatic injury model for 6 h to evaluate the hemocompatibility in vivo. Overall, HE staining and vWF immunohistochemistry all confirmed that heparin-coated DSM has a satisfactory anticoagulant effect. Based on the heparin-coated DSM, BALs were built with the use of rat primary hepatocytes. Our results demonstrate that these heparin-coated BALs satisfied anticoagulant effects even after 6 h. Immunofluorescence of ALB and G6PC also showed that hepatocytes in heparin-coated BAL have significantly higher cell viability and function than the non-coated group. However, serum analysis did not indicate a significant difference between the two groups but a slight trend of improvement with respect to serum albumin (p = 0.156) and aspartate transaminase (p = 0.140). In conclusion, we demonstrated that the BAL constructed by heparin-coated DSM can exert satisfactory short-term anticoagulant effects and can compensate for a certain degree of liver function." @default.
• W2901806411 created "2018-11-29" @default.
• W2901806411 creator A5008996333 @default.
• W2901806411 creator A5015368950 @default.
• W2901806411 creator A5018814025 @default.
• W2901806411 creator A5033897388 @default.
• W2901806411 creator A5034471264 @default.
• W2901806411 creator A5045030837 @default.
• W2901806411 creator A5046007194 @default.
• W2901806411 creator A5065522744 @default.
• W2901806411 creator A5083866167 @default.
• W2901806411 date "2019-01-04" @default.
• W2901806411 modified "2023-10-18" @default.
• W2901806411 title "Hemocompatibility improvement of decellularized spleen matrix for constructing transplantable bioartificial liver" @default.
• W2901806411 cites W1061628335 @default.
• W2901806411 cites W1490154674 @default.
• W2901806411 cites W1505044265 @default.
• W2901806411 cites W1755364265 @default.
• W2901806411 cites W1825249397 @default.
• W2901806411 cites W1965557044 @default.
• W2901806411 cites W1968928057 @default.
• W2901806411 cites W1989938134 @default.
• W2901806411 cites W2008565536 @default.
• W2901806411 cites W2051744951 @default.
• W2901806411 cites W2058221324 @default.
• W2901806411 cites W2059486645 @default.
• W2901806411 cites W2086519181 @default.
• W2901806411 cites W2110353731 @default.
• W2901806411 cites W2111338636 @default.
• W2901806411 cites W2224218846 @default.
• W2901806411 cites W2261148770 @default.
• W2901806411 cites W2285308423 @default.
• W2901806411 cites W2341478524 @default.
• W2901806411 cites W2346705306 @default.
• W2901806411 cites W2346854436 @default.
• W2901806411 cites W2410643502 @default.
• W2901806411 cites W2461170978 @default.
• W2901806411 cites W2466174295 @default.
• W2901806411 cites W2505395891 @default.
• W2901806411 cites W2564900473 @default.
• W2901806411 cites W2592704774 @default.
• W2901806411 cites W2594153159 @default.
• W2901806411 cites W2737883714 @default.
• W2901806411 cites W2752442160 @default.
• W2901806411 cites W2773047424 @default.
• W2901806411 cites W2796070610 @default.
• W2901806411 cites W28696350 @default.
• W2901806411 doi "https://doi.org/10.1088/1748-605x/aaf375" @default.
• W2901806411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30523825" @default.
• W2901806411 hasPublicationYear "2019" @default.
• W2901806411 type Work @default.
• W2901806411 sameAs 2901806411 @default.
• W2901806411 citedByCount "9" @default.
• W2901806411 countsByYear W29018064112020 @default.
• W2901806411 countsByYear W29018064112021 @default.
• W2901806411 countsByYear W29018064112022 @default.
• W2901806411 crossrefType "journal-article" @default.
• W2901806411 hasAuthorship W2901806411A5008996333 @default.
• W2901806411 hasAuthorship W2901806411A5015368950 @default.
• W2901806411 hasAuthorship W2901806411A5018814025 @default.
• W2901806411 hasAuthorship W2901806411A5033897388 @default.
• W2901806411 hasAuthorship W2901806411A5034471264 @default.
• W2901806411 hasAuthorship W2901806411A5045030837 @default.
• W2901806411 hasAuthorship W2901806411A5046007194 @default.
• W2901806411 hasAuthorship W2901806411A5065522744 @default.
• W2901806411 hasAuthorship W2901806411A5083866167 @default.
• W2901806411 hasConcept C126322002 @default.
• W2901806411 hasConcept C136229726 @default.
• W2901806411 hasConcept C141071460 @default.
• W2901806411 hasConcept C142724271 @default.
• W2901806411 hasConcept C185592680 @default.
• W2901806411 hasConcept C190672674 @default.
• W2901806411 hasConcept C192562407 @default.
• W2901806411 hasConcept C202751555 @default.
• W2901806411 hasConcept C2776200302 @default.
• W2901806411 hasConcept C2776649359 @default.
• W2901806411 hasConcept C2777557582 @default.
• W2901806411 hasConcept C2778205648 @default.
• W2901806411 hasConcept C2780931953 @default.
• W2901806411 hasConcept C49892992 @default.
• W2901806411 hasConcept C55493867 @default.
• W2901806411 hasConcept C71867830 @default.
• W2901806411 hasConcept C71924100 @default.
• W2901806411 hasConcept C74864618 @default.
• W2901806411 hasConcept C89560881 @default.
• W2901806411 hasConcept C98274493 @default.
• W2901806411 hasConceptScore W2901806411C126322002 @default.
• W2901806411 hasConceptScore W2901806411C136229726 @default.
• W2901806411 hasConceptScore W2901806411C141071460 @default.
• W2901806411 hasConceptScore W2901806411C142724271 @default.
• W2901806411 hasConceptScore W2901806411C185592680 @default.
• W2901806411 hasConceptScore W2901806411C190672674 @default.
• W2901806411 hasConceptScore W2901806411C192562407 @default.
• W2901806411 hasConceptScore W2901806411C202751555 @default.
• W2901806411 hasConceptScore W2901806411C2776200302 @default.
• W2901806411 hasConceptScore W2901806411C2776649359 @default.
• W2901806411 hasConceptScore W2901806411C2777557582 @default.
• W2901806411 hasConceptScore W2901806411C2778205648 @default.
• W2901806411 hasConceptScore W2901806411C2780931953 @default.
• W2901806411 hasConceptScore W2901806411C49892992 @default.

• next