FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901815488> ?p ?o ?g. }

• W2901815488 abstract "Malignant peripheral nerve sheath tumors (MPNSTs) are the leading cause of death in neurofibromatosis type 1 (NF1) patients. Current treatment modalities have been largely unsuccessful in improving MPNST patient survival, making the identification of new therapeutic targets urgent. In this study, we found that interference with Usp9X, a deubiquitinating enzyme which is overexpressed in nervous system tumors, or Mcl-1, an anti-apoptotic member of the Bcl-2 family whose degradation is regulated by Usp9X, causes rapid death in human MPNST cell lines. Although both Usp9X and Mcl-1 knockdown elicited some features of apoptosis, broad spectrum caspase inhibition was ineffective in preventing knockdown-induced MPNST cell death suggesting that caspase-independent death pathways were also activated. Ultrastructural examination of MPNST cells following either Usp9X interference or pharmacological inhibition showed extensive cytoplasmic vacuolization and swelling of endoplasmic reticulum (ER) and mitochondria most consistent with paraptotic cell death. Finally, the Usp9X pharmacological inhibitor WP1130 significantly reduced human MPNST growth and induced tumor cell death in an in vivo xenograft model. In total, these findings indicate that Usp9X and Mcl-1 play significant roles in maintaining human MPNST cell viability and that pharmacological inhibition of Usp9X deubiquitinase activity could be a therapeutic target for MPNST treatment." @default.
• W2901815488 created "2018-11-29" @default.
• W2901815488 creator A5019896041 @default.
• W2901815488 creator A5042737865 @default.
• W2901815488 creator A5045125797 @default.
• W2901815488 creator A5055489210 @default.
• W2901815488 creator A5071472484 @default.
• W2901815488 date "2018-11-26" @default.
• W2901815488 modified "2023-10-15" @default.
• W2901815488 title "Usp9X Regulates Cell Death in Malignant Peripheral Nerve Sheath Tumors" @default.
• W2901815488 cites W1625022788 @default.
• W2901815488 cites W1697178647 @default.
• W2901815488 cites W1827063072 @default.
• W2901815488 cites W1867601378 @default.
• W2901815488 cites W1888266266 @default.
• W2901815488 cites W1975750525 @default.
• W2901815488 cites W1979856883 @default.
• W2901815488 cites W1991249033 @default.
• W2901815488 cites W2007960245 @default.
• W2901815488 cites W2020511385 @default.
• W2901815488 cites W2027606367 @default.
• W2901815488 cites W2036700881 @default.
• W2901815488 cites W2047520539 @default.
• W2901815488 cites W2057710602 @default.
• W2901815488 cites W2059416155 @default.
• W2901815488 cites W2077398861 @default.
• W2901815488 cites W2082933218 @default.
• W2901815488 cites W2083395199 @default.
• W2901815488 cites W2089794529 @default.
• W2901815488 cites W2093354991 @default.
• W2901815488 cites W2133810023 @default.
• W2901815488 cites W2134404356 @default.
• W2901815488 cites W2154155095 @default.
• W2901815488 cites W2163970515 @default.
• W2901815488 cites W2164180823 @default.
• W2901815488 cites W2227783113 @default.
• W2901815488 cites W2253837246 @default.
• W2901815488 cites W2439038120 @default.
• W2901815488 cites W2536166319 @default.
• W2901815488 cites W2565888984 @default.
• W2901815488 cites W2568302777 @default.
• W2901815488 cites W2576633496 @default.
• W2901815488 cites W2597180544 @default.
• W2901815488 cites W2615465908 @default.
• W2901815488 cites W2616358207 @default.
• W2901815488 doi "https://doi.org/10.1038/s41598-018-35806-5" @default.
• W2901815488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6255814" @default.
• W2901815488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30478285" @default.
• W2901815488 hasPublicationYear "2018" @default.
• W2901815488 type Work @default.
• W2901815488 sameAs 2901815488 @default.
• W2901815488 citedByCount "11" @default.
• W2901815488 countsByYear W29018154882019 @default.
• W2901815488 countsByYear W29018154882020 @default.
• W2901815488 countsByYear W29018154882021 @default.
• W2901815488 countsByYear W29018154882022 @default.
• W2901815488 countsByYear W29018154882023 @default.
• W2901815488 crossrefType "journal-article" @default.
• W2901815488 hasAuthorship W2901815488A5019896041 @default.
• W2901815488 hasAuthorship W2901815488A5042737865 @default.
• W2901815488 hasAuthorship W2901815488A5045125797 @default.
• W2901815488 hasAuthorship W2901815488A5055489210 @default.
• W2901815488 hasAuthorship W2901815488A5071472484 @default.
• W2901815488 hasBestOaLocation W29018154881 @default.
• W2901815488 hasConcept C102658986 @default.
• W2901815488 hasConcept C104317684 @default.
• W2901815488 hasConcept C142724271 @default.
• W2901815488 hasConcept C173396325 @default.
• W2901815488 hasConcept C190283241 @default.
• W2901815488 hasConcept C25602115 @default.
• W2901815488 hasConcept C2778173781 @default.
• W2901815488 hasConcept C2778614373 @default.
• W2901815488 hasConcept C2778984943 @default.
• W2901815488 hasConcept C31573885 @default.
• W2901815488 hasConcept C502942594 @default.
• W2901815488 hasConcept C55493867 @default.
• W2901815488 hasConcept C71924100 @default.
• W2901815488 hasConcept C86803240 @default.
• W2901815488 hasConceptScore W2901815488C102658986 @default.
• W2901815488 hasConceptScore W2901815488C104317684 @default.
• W2901815488 hasConceptScore W2901815488C142724271 @default.
• W2901815488 hasConceptScore W2901815488C173396325 @default.
• W2901815488 hasConceptScore W2901815488C190283241 @default.
• W2901815488 hasConceptScore W2901815488C25602115 @default.
• W2901815488 hasConceptScore W2901815488C2778173781 @default.
• W2901815488 hasConceptScore W2901815488C2778614373 @default.
• W2901815488 hasConceptScore W2901815488C2778984943 @default.
• W2901815488 hasConceptScore W2901815488C31573885 @default.
• W2901815488 hasConceptScore W2901815488C502942594 @default.
• W2901815488 hasConceptScore W2901815488C55493867 @default.
• W2901815488 hasConceptScore W2901815488C71924100 @default.
• W2901815488 hasConceptScore W2901815488C86803240 @default.
• W2901815488 hasFunder F4320306078 @default.
• W2901815488 hasFunder F4320337351 @default.
• W2901815488 hasFunder F4320337359 @default.
• W2901815488 hasIssue "1" @default.
• W2901815488 hasLocation W29018154881 @default.
• W2901815488 hasLocation W29018154882 @default.
• W2901815488 hasLocation W29018154883 @default.
• W2901815488 hasLocation W29018154884 @default.

• next