Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901817521> ?p ?o ?g. }
- W2901817521 endingPage "199" @default.
- W2901817521 startingPage "190" @default.
- W2901817521 abstract "Oral squamous cell carcinoma (OSCC) is the most common malignant cancer, with high mortality rates in advanced stages. Recent studies have shown that the expression of ALPK1 mRNA and its inhibitory differentiation function are associated with cancer progression. However, the expression and clinicopathologic features of ALPK1 in OSCC remain unexplored. Herein, the authors investigated the expression patterns of ALPK1 in 39 matched OSCC patients and examined the relationship between ALPK1 protein expression and clinicopathologic factors using immunohistochemical scores. Using Western blot analysis, ALPK1 expression was found to be significantly higher in tumor tissues than that in nontumor tissues. Through an immunoreactive scoring system, a significantly higher number of advanced-stage tumor size T4 and lymph node metastasis N2 exhibited higher ALPK1 expression levels than that exhibited by T1/T2/T3 tumors and N0/N1. In addition, ALPK1 protein expression was aberrant in malignant oral cancer cell lines compared with that in pre-malignant oral epithelial cells, whereas minimal expression was observed in normal oral epithelial cells. Knockdown of ALPK1 resulted in a significant reduction in cell growth, migration, and invasion capacity in vitro. Consequently, expression of N-cadherin and vimentin decreased in ALPK1-deficient cells. Thus, these results suggest that ALPK1 serves as a potential biomarker and target for OSCC development in late stages." @default.
- W2901817521 created "2018-11-29" @default.
- W2901817521 creator A5030670961 @default.
- W2901817521 creator A5043333442 @default.
- W2901817521 creator A5045333057 @default.
- W2901817521 creator A5056788629 @default.
- W2901817521 creator A5058305068 @default.
- W2901817521 creator A5061547257 @default.
- W2901817521 creator A5067150020 @default.
- W2901817521 creator A5072563983 @default.
- W2901817521 creator A5085706377 @default.
- W2901817521 date "2019-01-01" @default.
- W2901817521 modified "2023-10-18" @default.
- W2901817521 title "ALPK1 Expression Is Associated with Lymph Node Metastasis and Tumor Growth in Oral Squamous Cell Carcinoma Patients" @default.
- W2901817521 cites W1496606526 @default.
- W2901817521 cites W1597197478 @default.
- W2901817521 cites W1883079188 @default.
- W2901817521 cites W1954576485 @default.
- W2901817521 cites W1982483822 @default.
- W2901817521 cites W1987602380 @default.
- W2901817521 cites W1993990713 @default.
- W2901817521 cites W1995541297 @default.
- W2901817521 cites W2006004173 @default.
- W2901817521 cites W2012729913 @default.
- W2901817521 cites W2021700900 @default.
- W2901817521 cites W2030029307 @default.
- W2901817521 cites W2036372593 @default.
- W2901817521 cites W2036674239 @default.
- W2901817521 cites W2048229450 @default.
- W2901817521 cites W2073878222 @default.
- W2901817521 cites W2076583198 @default.
- W2901817521 cites W2076797886 @default.
- W2901817521 cites W2080261745 @default.
- W2901817521 cites W2084863590 @default.
- W2901817521 cites W2094089333 @default.
- W2901817521 cites W2095746901 @default.
- W2901817521 cites W2108120163 @default.
- W2901817521 cites W2112825838 @default.
- W2901817521 cites W2120168819 @default.
- W2901817521 cites W2122423445 @default.
- W2901817521 cites W2126777451 @default.
- W2901817521 cites W2132052921 @default.
- W2901817521 cites W2133615225 @default.
- W2901817521 cites W2136871952 @default.
- W2901817521 cites W2142812093 @default.
- W2901817521 cites W2150196913 @default.
- W2901817521 cites W2157946848 @default.
- W2901817521 cites W2167030621 @default.
- W2901817521 cites W2189132033 @default.
- W2901817521 cites W2220948290 @default.
- W2901817521 cites W2374914800 @default.
- W2901817521 cites W2419488572 @default.
- W2901817521 cites W2511396244 @default.
- W2901817521 cites W2547244800 @default.
- W2901817521 cites W2590679695 @default.
- W2901817521 cites W2604610798 @default.
- W2901817521 cites W2607075581 @default.
- W2901817521 cites W2607323894 @default.
- W2901817521 cites W2614296412 @default.
- W2901817521 cites W2767054968 @default.
- W2901817521 cites W973171548 @default.
- W2901817521 doi "https://doi.org/10.1016/j.ajpath.2018.09.003" @default.
- W2901817521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315765" @default.
- W2901817521 hasPublicationYear "2019" @default.
- W2901817521 type Work @default.
- W2901817521 sameAs 2901817521 @default.
- W2901817521 citedByCount "13" @default.
- W2901817521 countsByYear W29018175212019 @default.
- W2901817521 countsByYear W29018175212020 @default.
- W2901817521 countsByYear W29018175212021 @default.
- W2901817521 countsByYear W29018175212022 @default.
- W2901817521 countsByYear W29018175212023 @default.
- W2901817521 crossrefType "journal-article" @default.
- W2901817521 hasAuthorship W2901817521A5030670961 @default.
- W2901817521 hasAuthorship W2901817521A5043333442 @default.
- W2901817521 hasAuthorship W2901817521A5045333057 @default.
- W2901817521 hasAuthorship W2901817521A5056788629 @default.
- W2901817521 hasAuthorship W2901817521A5058305068 @default.
- W2901817521 hasAuthorship W2901817521A5061547257 @default.
- W2901817521 hasAuthorship W2901817521A5067150020 @default.
- W2901817521 hasAuthorship W2901817521A5072563983 @default.
- W2901817521 hasAuthorship W2901817521A5085706377 @default.
- W2901817521 hasBestOaLocation W29018175211 @default.
- W2901817521 hasConcept C104317684 @default.
- W2901817521 hasConcept C121608353 @default.
- W2901817521 hasConcept C142724271 @default.
- W2901817521 hasConcept C147447768 @default.
- W2901817521 hasConcept C1491633281 @default.
- W2901817521 hasConcept C173396325 @default.
- W2901817521 hasConcept C204232928 @default.
- W2901817521 hasConcept C2776415932 @default.
- W2901817521 hasConcept C2779013556 @default.
- W2901817521 hasConcept C2780849966 @default.
- W2901817521 hasConcept C502942594 @default.
- W2901817521 hasConcept C54355233 @default.
- W2901817521 hasConcept C55493867 @default.
- W2901817521 hasConcept C71924100 @default.
- W2901817521 hasConcept C81885089 @default.