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• W2901830822 abstract "Cisplatin resistance is a major cause of treatment failure in advanced ovarian cancer. The limited evidence shows the paradoxical regulation of miR-205 on chemotherapy resistance in cancer. Herein, we found that miR-205-5p was enormously increased in cisplatin-resistant C13K ovarian cancer cells compared with its cisplatin-sensitive OV2008 parental cells using miRNA microarrays, which was further verified by quantitative PCR. Furthermore, we confirmed that inhibition of miR-205-5p upregulated PTEN and subsequently attenuated its downstream target p-AKT, which inversed C13K cells from cisplatin resistance to sensitivity. Our data suggest that miR-205-5p contributes to cisplatin resistance in C13K ovarian cancer cells may via targeting PTEN/AKT pathway." @default.
• W2901830822 created "2018-11-29" @default.
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• W2901830822 date "2018-11-19" @default.
• W2901830822 modified "2023-10-18" @default.
• W2901830822 title "miR-205-5p Mediated Downregulation of PTEN Contributes to Cisplatin Resistance in C13K Human Ovarian Cancer Cells" @default.
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• W2901830822 doi "https://doi.org/10.3389/fgene.2018.00555" @default.
• W2901830822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6253938" @default.
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