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- W2901838085 abstract "Abstract Objective: The purpose of this study was to investigate the association of microRNA polymorphisms ( miR-25 T>C, miR-32 C>A, miR-125 C>T, and miR-222 G>T) with primary ovarian insufficiency (POI) in Korean women. Methods: We conducted a case-control study of Korean women: 142 participants with POI and 266 controls with at least 1 live birth and no history of pregnancy loss. Results: The haplotype-based multifactor dimensionality reduction analysis revealed that the T-C-T-G ( miR-25/-32/-125/-222 ), T-A-C-G ( miR-25/-32/-125/-222 ), C-T-G ( miR-32/-125/-222 ), A-C-G ( miR-32/-125/-222 ), T-G ( miR-122/-222 ), C-T ( miR-32/-125 ), and C-C ( miR-25/-32 ) inferred haplotypes were significantly less frequent in POI ( P < 0.05), which suggested potential protective effects. Participants with POI had significantly increased luteinizing hormone levels ( P < 0.05), but hormonal levels, including luteinizing hormone, were not significantly different between POI women and control women with miR-32/-125/-222 . Conclusions: After considering multiple comparisons, we concluded that miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T had no relation with POI." @default.
- W2901838085 created "2018-11-29" @default.
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- W2901838085 date "2019-04-01" @default.
- W2901838085 modified "2023-10-14" @default.
- W2901838085 title "The association of miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T polymorphisms with a risk of primary ovarian insufficiency in Korean women" @default.
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- W2901838085 doi "https://doi.org/10.1097/gme.0000000000001258" @default.
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