FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901852085> ?p ?o ?g. }

• W2901852085 endingPage "440" @default.
• W2901852085 startingPage "440" @default.
• W2901852085 abstract "Phospholipase D (PLD) is involved in many biological processes. PLD1 plays a crucial role in regulating the platelet activity of mice; however, the role of PLD in the platelet activation of humans remains unclear. Therefore, we investigated whether PLD is involved in the platelet activation of humans. Our data revealed that inhibition of PLD1 or PLD2 using pharmacological inhibitors effectively inhibits platelet aggregation in humans. However, previous studies have showed that PLD1 or PLD2 deletion did not affect mouse platelet aggregation in vitro, whereas only PLD1 deletion inhibited thrombus formation in vivo. Intriguingly, our data also showed that the pharmacological inhibition of PLD1 or PLD2 does not affect mouse platelet aggregation in vitro, whereas the inhibition of only PLD1 delayed thrombus formation in vivo. These findings indicate that PLD may play differential roles in humans and mice. In humans, PLD inhibition attenuates platelet activation, adhesion, spreading, and clot retraction. For the first time, we demonstrated that PLD1 and PLD2 are essential for platelet activation in humans, and PLD plays different roles in platelet function in humans and mice. Our findings also indicate that targeting PLD may provide a safe and alternative therapeutic approach for preventing thromboembolic disorders." @default.
• W2901852085 created "2018-11-29" @default.
• W2901852085 creator A5001077780 @default.
• W2901852085 creator A5020877227 @default.
• W2901852085 creator A5022184391 @default.
• W2901852085 creator A5025047436 @default.
• W2901852085 creator A5032789979 @default.
• W2901852085 creator A5052370583 @default.
• W2901852085 creator A5056401612 @default.
• W2901852085 creator A5082325105 @default.
• W2901852085 date "2018-11-14" @default.
• W2901852085 modified "2023-10-16" @default.
• W2901852085 title "An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets" @default.
• W2901852085 cites W1480729244 @default.
• W2901852085 cites W1953933918 @default.
• W2901852085 cites W1963967561 @default.
• W2901852085 cites W1971095341 @default.
• W2901852085 cites W1972750612 @default.
• W2901852085 cites W1973453444 @default.
• W2901852085 cites W1984241869 @default.
• W2901852085 cites W1993159760 @default.
• W2901852085 cites W2008492030 @default.
• W2901852085 cites W2016544534 @default.
• W2901852085 cites W2019435017 @default.
• W2901852085 cites W2020707198 @default.
• W2901852085 cites W2036636564 @default.
• W2901852085 cites W2046589593 @default.
• W2901852085 cites W2046737719 @default.
• W2901852085 cites W2053399051 @default.
• W2901852085 cites W2059159442 @default.
• W2901852085 cites W2071552704 @default.
• W2901852085 cites W2077130731 @default.
• W2901852085 cites W2091969736 @default.
• W2901852085 cites W2100089051 @default.
• W2901852085 cites W2109963121 @default.
• W2901852085 cites W2121836743 @default.
• W2901852085 cites W2129303232 @default.
• W2901852085 cites W2136478232 @default.
• W2901852085 cites W2143976331 @default.
• W2901852085 cites W2165938620 @default.
• W2901852085 cites W2166535571 @default.
• W2901852085 cites W2173000237 @default.
• W2901852085 cites W2284815995 @default.
• W2901852085 cites W2340670419 @default.
• W2901852085 doi "https://doi.org/10.3390/jcm7110440" @default.
• W2901852085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6262437" @default.
• W2901852085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30441821" @default.
• W2901852085 hasPublicationYear "2018" @default.
• W2901852085 type Work @default.
• W2901852085 sameAs 2901852085 @default.
• W2901852085 citedByCount "6" @default.
• W2901852085 countsByYear W29018520852019 @default.
• W2901852085 countsByYear W29018520852020 @default.
• W2901852085 countsByYear W29018520852021 @default.
• W2901852085 countsByYear W29018520852023 @default.
• W2901852085 crossrefType "journal-article" @default.
• W2901852085 hasAuthorship W2901852085A5001077780 @default.
• W2901852085 hasAuthorship W2901852085A5020877227 @default.
• W2901852085 hasAuthorship W2901852085A5022184391 @default.
• W2901852085 hasAuthorship W2901852085A5025047436 @default.
• W2901852085 hasAuthorship W2901852085A5032789979 @default.
• W2901852085 hasAuthorship W2901852085A5052370583 @default.
• W2901852085 hasAuthorship W2901852085A5056401612 @default.
• W2901852085 hasAuthorship W2901852085A5082325105 @default.
• W2901852085 hasBestOaLocation W29018520851 @default.
• W2901852085 hasConcept C126322002 @default.
• W2901852085 hasConcept C150903083 @default.
• W2901852085 hasConcept C180373561 @default.
• W2901852085 hasConcept C185592680 @default.
• W2901852085 hasConcept C202751555 @default.
• W2901852085 hasConcept C203014093 @default.
• W2901852085 hasConcept C207001950 @default.
• W2901852085 hasConcept C2776909261 @default.
• W2901852085 hasConcept C2777015399 @default.
• W2901852085 hasConcept C2778918659 @default.
• W2901852085 hasConcept C2781362458 @default.
• W2901852085 hasConcept C3018697912 @default.
• W2901852085 hasConcept C41625074 @default.
• W2901852085 hasConcept C55493867 @default.
• W2901852085 hasConcept C6182249 @default.
• W2901852085 hasConcept C62478195 @default.
• W2901852085 hasConcept C71924100 @default.
• W2901852085 hasConcept C86803240 @default.
• W2901852085 hasConcept C89560881 @default.
• W2901852085 hasConcept C95444343 @default.
• W2901852085 hasConcept C98274493 @default.
• W2901852085 hasConceptScore W2901852085C126322002 @default.
• W2901852085 hasConceptScore W2901852085C150903083 @default.
• W2901852085 hasConceptScore W2901852085C180373561 @default.
• W2901852085 hasConceptScore W2901852085C185592680 @default.
• W2901852085 hasConceptScore W2901852085C202751555 @default.
• W2901852085 hasConceptScore W2901852085C203014093 @default.
• W2901852085 hasConceptScore W2901852085C207001950 @default.
• W2901852085 hasConceptScore W2901852085C2776909261 @default.
• W2901852085 hasConceptScore W2901852085C2777015399 @default.
• W2901852085 hasConceptScore W2901852085C2778918659 @default.
• W2901852085 hasConceptScore W2901852085C2781362458 @default.
• W2901852085 hasConceptScore W2901852085C3018697912 @default.

• next