FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901873089> ?p ?o ?g. }

• W2901873089 endingPage "81" @default.
• W2901873089 startingPage "77" @default.
• W2901873089 abstract "Alteration of gene expression profile in CD3+ T-cells after downregulating MALT1 Xu Wang,1,2,* Shuai Lu,1,2,* Yankai Xiao,1,2 Ling Xu,2,3 Lingling Zhou,1,2 Junyan Hu,2 Bo Li,1,2 Chengwu Zeng,1,2 Yangqiu Li1–3 1Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, People’s Republic of China; 2Institute of Hematology, Jinan University, Guangzhou, 510632, People’s Republic of China; 3Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, People’s Republic of China *These authors contributed equally to this work Background: T cell immunodeficiency is a common feature in patients with different kinds of hematological disease such as T cell non-Hodgkin lymphoma (T-NHL), B cells NHL (B-NHL), NK/T cell NHL (NK/T-CL) and acute myeloid leukemia (AML). In our recent research, we found that significantly lower expression levels in MALT1 and NF-κB were related to suppression of T cell activation. Therefore, this study was conducted to further investigate the role of downregulating MALT1 in the development of immunodeficiency in T cells.Methods: We induced activation inhibition in CD3+ T cells by MALT1 knockdown. Then we characterized the gene expression profile after MALT1 suppression by microarray analysis.Result: The differentially expressed genes were ZAP-70, p65, MDM2, ATM, NFATC2 which participate in the NF-κB, p53, and NFAT pathways in CD3+ T cells after MALT1 downregulation.Conclusion: MALT1 suppression may contribute to immunodeficiency in T cells via suppression of T cell activation and proliferation pathways. These data may help to explain some of the characteristics of immunodeficiency of T cells. Keywords: CD3+ T-cells, MALT1, immunodeficiency, T-cell activation, microarray" @default.
• W2901873089 created "2018-11-29" @default.
• W2901873089 creator A5007159963 @default.
• W2901873089 creator A5030965415 @default.
• W2901873089 creator A5036901902 @default.
• W2901873089 creator A5054175249 @default.
• W2901873089 creator A5056101043 @default.
• W2901873089 creator A5064726724 @default.
• W2901873089 creator A5072612814 @default.
• W2901873089 creator A5077001548 @default.
• W2901873089 creator A5090713571 @default.
• W2901873089 date "2018-11-01" @default.
• W2901873089 modified "2023-10-17" @default.
• W2901873089 title "Alteration of gene expression profile in CD3⁺ T-cells after downregulating MALT1" @default.
• W2901873089 cites W1569503463 @default.
• W2901873089 cites W1966841369 @default.
• W2901873089 cites W1968373686 @default.
• W2901873089 cites W1973922247 @default.
• W2901873089 cites W1975203744 @default.
• W2901873089 cites W1999410989 @default.
• W2901873089 cites W2001545384 @default.
• W2901873089 cites W2003310227 @default.
• W2901873089 cites W2028382049 @default.
• W2901873089 cites W2040068538 @default.
• W2901873089 cites W2060416013 @default.
• W2901873089 cites W2074150439 @default.
• W2901873089 cites W2088852852 @default.
• W2901873089 cites W2090487809 @default.
• W2901873089 cites W2092977634 @default.
• W2901873089 cites W2094863064 @default.
• W2901873089 cites W2118083075 @default.
• W2901873089 cites W2123490898 @default.
• W2901873089 cites W2151892297 @default.
• W2901873089 cites W2166883361 @default.
• W2901873089 cites W2168580711 @default.
• W2901873089 cites W2409672023 @default.
• W2901873089 cites W2744424523 @default.
• W2901873089 doi "https://doi.org/10.2147/itt.s179656" @default.
• W2901873089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6251356" @default.
• W2901873089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30538965" @default.
• W2901873089 hasPublicationYear "2018" @default.
• W2901873089 type Work @default.
• W2901873089 sameAs 2901873089 @default.
• W2901873089 citedByCount "0" @default.
• W2901873089 crossrefType "journal-article" @default.
• W2901873089 hasAuthorship W2901873089A5007159963 @default.
• W2901873089 hasAuthorship W2901873089A5030965415 @default.
• W2901873089 hasAuthorship W2901873089A5036901902 @default.
• W2901873089 hasAuthorship W2901873089A5054175249 @default.
• W2901873089 hasAuthorship W2901873089A5056101043 @default.
• W2901873089 hasAuthorship W2901873089A5064726724 @default.
• W2901873089 hasAuthorship W2901873089A5072612814 @default.
• W2901873089 hasAuthorship W2901873089A5077001548 @default.
• W2901873089 hasAuthorship W2901873089A5090713571 @default.
• W2901873089 hasBestOaLocation W29018730891 @default.
• W2901873089 hasConcept C104317684 @default.
• W2901873089 hasConcept C114684123 @default.
• W2901873089 hasConcept C153911025 @default.
• W2901873089 hasConcept C167672396 @default.
• W2901873089 hasConcept C173396325 @default.
• W2901873089 hasConcept C189938988 @default.
• W2901873089 hasConcept C203014093 @default.
• W2901873089 hasConcept C2776090121 @default.
• W2901873089 hasConcept C502942594 @default.
• W2901873089 hasConcept C54355233 @default.
• W2901873089 hasConcept C71924100 @default.
• W2901873089 hasConcept C81885089 @default.
• W2901873089 hasConcept C86339819 @default.
• W2901873089 hasConcept C86803240 @default.
• W2901873089 hasConcept C8891405 @default.
• W2901873089 hasConceptScore W2901873089C104317684 @default.
• W2901873089 hasConceptScore W2901873089C114684123 @default.
• W2901873089 hasConceptScore W2901873089C153911025 @default.
• W2901873089 hasConceptScore W2901873089C167672396 @default.
• W2901873089 hasConceptScore W2901873089C173396325 @default.
• W2901873089 hasConceptScore W2901873089C189938988 @default.
• W2901873089 hasConceptScore W2901873089C203014093 @default.
• W2901873089 hasConceptScore W2901873089C2776090121 @default.
• W2901873089 hasConceptScore W2901873089C502942594 @default.
• W2901873089 hasConceptScore W2901873089C54355233 @default.
• W2901873089 hasConceptScore W2901873089C71924100 @default.
• W2901873089 hasConceptScore W2901873089C81885089 @default.
• W2901873089 hasConceptScore W2901873089C86339819 @default.
• W2901873089 hasConceptScore W2901873089C86803240 @default.
• W2901873089 hasConceptScore W2901873089C8891405 @default.
• W2901873089 hasLocation W29018730891 @default.
• W2901873089 hasLocation W29018730892 @default.
• W2901873089 hasLocation W29018730893 @default.
• W2901873089 hasLocation W29018730894 @default.
• W2901873089 hasOpenAccess W2901873089 @default.
• W2901873089 hasPrimaryLocation W29018730891 @default.
• W2901873089 hasRelatedWork W102043283 @default.
• W2901873089 hasRelatedWork W1503092209 @default.
• W2901873089 hasRelatedWork W1981231261 @default.
• W2901873089 hasRelatedWork W1995181168 @default.
• W2901873089 hasRelatedWork W2006758543 @default.
• W2901873089 hasRelatedWork W2025637968 @default.
• W2901873089 hasRelatedWork W2048446519 @default.

• next