Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901884480> ?p ?o ?g. }
- W2901884480 endingPage "1513" @default.
- W2901884480 startingPage "1499" @default.
- W2901884480 abstract "In cells lacking telomerase, telomeres gradually shorten during each cell division to reach a critically short length, permanently activate the DNA damage checkpoint, and trigger replicative senescence. The increase in genome instability that occurs as a consequence may contribute to the early steps of tumorigenesis. However, because of the low frequency of mutations and the heterogeneity of telomere-induced senescence, the timing and mechanisms of genome instability increase remain elusive. Here, to capture early mutation events during replicative senescence, we used a combined microfluidic-based approach and live-cell imaging in yeast. We analyzed DNA damage checkpoint activation in consecutive cell divisions of individual cell lineages in telomerase-negative yeast cells and observed that prolonged checkpoint arrests occurred frequently in telomerase-negative lineages. Cells relied on the adaptation to the DNA damage pathway to bypass the prolonged checkpoint arrests, allowing further cell divisions despite the presence of unrepaired DNA damage. We demonstrate that the adaptation pathway is a major contributor to the genome instability induced during replicative senescence. Therefore, adaptation plays a critical role in shaping the dynamics of genome instability during replicative senescence." @default.
- W2901884480 created "2018-11-29" @default.
- W2901884480 creator A5016864857 @default.
- W2901884480 creator A5028250091 @default.
- W2901884480 creator A5038381556 @default.
- W2901884480 creator A5069577373 @default.
- W2901884480 creator A5071559560 @default.
- W2901884480 creator A5072951473 @default.
- W2901884480 creator A5077381000 @default.
- W2901884480 creator A5083225830 @default.
- W2901884480 date "2018-11-21" @default.
- W2901884480 modified "2023-10-16" @default.
- W2901884480 title "Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability" @default.
- W2901884480 cites W1480404031 @default.
- W2901884480 cites W1529432107 @default.
- W2901884480 cites W1612842202 @default.
- W2901884480 cites W1964071811 @default.
- W2901884480 cites W1965980401 @default.
- W2901884480 cites W1969153822 @default.
- W2901884480 cites W1970891016 @default.
- W2901884480 cites W1970924670 @default.
- W2901884480 cites W1975016370 @default.
- W2901884480 cites W1975425948 @default.
- W2901884480 cites W1977871027 @default.
- W2901884480 cites W1980725176 @default.
- W2901884480 cites W1983623780 @default.
- W2901884480 cites W1987609716 @default.
- W2901884480 cites W1993152080 @default.
- W2901884480 cites W1997432012 @default.
- W2901884480 cites W2002407831 @default.
- W2901884480 cites W2006765383 @default.
- W2901884480 cites W2008986696 @default.
- W2901884480 cites W2011799603 @default.
- W2901884480 cites W2013735712 @default.
- W2901884480 cites W2014401442 @default.
- W2901884480 cites W2015821968 @default.
- W2901884480 cites W2015830666 @default.
- W2901884480 cites W2024442567 @default.
- W2901884480 cites W2027779909 @default.
- W2901884480 cites W2031292590 @default.
- W2901884480 cites W2034269086 @default.
- W2901884480 cites W2035910115 @default.
- W2901884480 cites W2042000503 @default.
- W2901884480 cites W2043204829 @default.
- W2901884480 cites W2045888701 @default.
- W2901884480 cites W2048729396 @default.
- W2901884480 cites W2049353065 @default.
- W2901884480 cites W2060107244 @default.
- W2901884480 cites W2062258025 @default.
- W2901884480 cites W2064732318 @default.
- W2901884480 cites W2065369524 @default.
- W2901884480 cites W2069839388 @default.
- W2901884480 cites W2069849791 @default.
- W2901884480 cites W2070696523 @default.
- W2901884480 cites W2075478564 @default.
- W2901884480 cites W2079113820 @default.
- W2901884480 cites W2081948472 @default.
- W2901884480 cites W2083168268 @default.
- W2901884480 cites W2083753924 @default.
- W2901884480 cites W2086877549 @default.
- W2901884480 cites W2098085059 @default.
- W2901884480 cites W2106322056 @default.
- W2901884480 cites W2107130407 @default.
- W2901884480 cites W2107820972 @default.
- W2901884480 cites W2111723163 @default.
- W2901884480 cites W2117692326 @default.
- W2901884480 cites W2122658576 @default.
- W2901884480 cites W2126004462 @default.
- W2901884480 cites W2132793860 @default.
- W2901884480 cites W2135612520 @default.
- W2901884480 cites W2144538041 @default.
- W2901884480 cites W2148530409 @default.
- W2901884480 cites W2148869040 @default.
- W2901884480 cites W2149390987 @default.
- W2901884480 cites W2167279371 @default.
- W2901884480 cites W2169911836 @default.
- W2901884480 cites W2171393588 @default.
- W2901884480 cites W2179663139 @default.
- W2901884480 cites W2197269124 @default.
- W2901884480 cites W2267575889 @default.
- W2901884480 cites W2464372340 @default.
- W2901884480 cites W2520113997 @default.
- W2901884480 cites W2528485857 @default.
- W2901884480 cites W2550983084 @default.
- W2901884480 cites W2577194681 @default.
- W2901884480 cites W2740698915 @default.
- W2901884480 cites W2761193356 @default.
- W2901884480 cites W2767771270 @default.
- W2901884480 doi "https://doi.org/10.1101/gad.318485.118" @default.
- W2901884480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6295172" @default.
- W2901884480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30463903" @default.
- W2901884480 hasPublicationYear "2018" @default.
- W2901884480 type Work @default.
- W2901884480 sameAs 2901884480 @default.
- W2901884480 citedByCount "40" @default.
- W2901884480 countsByYear W29018844802018 @default.
- W2901884480 countsByYear W29018844802019 @default.
- W2901884480 countsByYear W29018844802020 @default.