Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901917768> ?p ?o ?g. }
- W2901917768 endingPage "1052" @default.
- W2901917768 startingPage "1033" @default.
- W2901917768 abstract "Introduction: Proteasome inhibitors (PIs) are therapeutic backbones of multiple myeloma treatment, with PI-based therapies being standards of care throughout the treatment algorithm. Proteasome inhibition affects multiple critical signaling pathways in myeloma cells and interacts synergistically with mechanisms of action of other conventional and novel agents, resulting in substantial anti-myeloma activity and at least additive effects.Areas covered: This review summarizes the biologic effects of proteasome inhibition in myeloma and provides an overview of the importance of proteasome inhibition to the current treatment algorithm. It reviews key clinical data on three PIs, specifically bortezomib, carfilzomib, and ixazomib; assesses ongoing phase 3 trials with these agents; and looks ahead to the increasingly broad role of both approved PIs and PIs under investigation in the frontline and relapsed settings.Expert commentary: Progress to date with PIs in multiple myeloma has been impressive, but there remain unmet needs and challenges, as well as increasing opportunities to optimize the use of these agents. Understanding discrepancies between PIs in terms of efficacy and safety profile is a key goal of ongoing research, along with proteomics-based efforts to identify potential biomarkers of sensitivity and resistance, thereby enabling increasingly personalized treatment approaches in the future." @default.
- W2901917768 created "2018-11-29" @default.
- W2901917768 creator A5006765393 @default.
- W2901917768 creator A5012712111 @default.
- W2901917768 creator A5032464400 @default.
- W2901917768 creator A5043526996 @default.
- W2901917768 creator A5049711954 @default.
- W2901917768 creator A5061196957 @default.
- W2901917768 creator A5068511166 @default.
- W2901917768 creator A5091207345 @default.
- W2901917768 date "2018-11-14" @default.
- W2901917768 modified "2023-10-08" @default.
- W2901917768 title "The power of proteasome inhibition in multiple myeloma" @default.
- W2901917768 cites W1516702206 @default.
- W2901917768 cites W1544981048 @default.
- W2901917768 cites W1759028523 @default.
- W2901917768 cites W1773271542 @default.
- W2901917768 cites W1804942062 @default.
- W2901917768 cites W1898969431 @default.
- W2901917768 cites W1952760452 @default.
- W2901917768 cites W1955748620 @default.
- W2901917768 cites W1963853457 @default.
- W2901917768 cites W1967438746 @default.
- W2901917768 cites W1978735501 @default.
- W2901917768 cites W1979068418 @default.
- W2901917768 cites W1980168719 @default.
- W2901917768 cites W1981758758 @default.
- W2901917768 cites W1985275612 @default.
- W2901917768 cites W1985864219 @default.
- W2901917768 cites W1987583882 @default.
- W2901917768 cites W1989740966 @default.
- W2901917768 cites W1993959807 @default.
- W2901917768 cites W1999177459 @default.
- W2901917768 cites W1999964913 @default.
- W2901917768 cites W2006798542 @default.
- W2901917768 cites W2012832145 @default.
- W2901917768 cites W2013370486 @default.
- W2901917768 cites W2015003025 @default.
- W2901917768 cites W2015668100 @default.
- W2901917768 cites W2020298011 @default.
- W2901917768 cites W2023661149 @default.
- W2901917768 cites W2025579499 @default.
- W2901917768 cites W2033944464 @default.
- W2901917768 cites W2037132614 @default.
- W2901917768 cites W2039496823 @default.
- W2901917768 cites W2050829096 @default.
- W2901917768 cites W2055338149 @default.
- W2901917768 cites W2067653691 @default.
- W2901917768 cites W2068889400 @default.
- W2901917768 cites W2070790769 @default.
- W2901917768 cites W2073817882 @default.
- W2901917768 cites W2079278201 @default.
- W2901917768 cites W2082863510 @default.
- W2901917768 cites W2083365324 @default.
- W2901917768 cites W2088674645 @default.
- W2901917768 cites W2088765731 @default.
- W2901917768 cites W2089311432 @default.
- W2901917768 cites W2090310344 @default.
- W2901917768 cites W2091378741 @default.
- W2901917768 cites W2095384810 @default.
- W2901917768 cites W2096207943 @default.
- W2901917768 cites W2096367061 @default.
- W2901917768 cites W2102088366 @default.
- W2901917768 cites W2104039873 @default.
- W2901917768 cites W2106692847 @default.
- W2901917768 cites W2109371953 @default.
- W2901917768 cites W2111650326 @default.
- W2901917768 cites W2117237065 @default.
- W2901917768 cites W2120590293 @default.
- W2901917768 cites W2120780398 @default.
- W2901917768 cites W2124560610 @default.
- W2901917768 cites W2124668830 @default.
- W2901917768 cites W2126267349 @default.
- W2901917768 cites W2129937834 @default.
- W2901917768 cites W2131491521 @default.
- W2901917768 cites W2131574772 @default.
- W2901917768 cites W2133268402 @default.
- W2901917768 cites W2134401047 @default.
- W2901917768 cites W2134902298 @default.
- W2901917768 cites W2135788003 @default.
- W2901917768 cites W2141105112 @default.
- W2901917768 cites W2142368474 @default.
- W2901917768 cites W2143538182 @default.
- W2901917768 cites W2144118007 @default.
- W2901917768 cites W2144797350 @default.
- W2901917768 cites W2145412346 @default.
- W2901917768 cites W2150878522 @default.
- W2901917768 cites W2152065071 @default.
- W2901917768 cites W2153716391 @default.
- W2901917768 cites W2158106888 @default.
- W2901917768 cites W2159195400 @default.
- W2901917768 cites W2160088903 @default.
- W2901917768 cites W2162771614 @default.
- W2901917768 cites W2165065963 @default.
- W2901917768 cites W2168980644 @default.
- W2901917768 cites W2169183166 @default.
- W2901917768 cites W2169295136 @default.
- W2901917768 cites W2169590701 @default.