Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901923894> ?p ?o ?g. }
- W2901923894 endingPage "31" @default.
- W2901923894 startingPage "21" @default.
- W2901923894 abstract "The APOBEC3 enzyme family are host restriction factors that induce mutagenesis of HIV-1 proviral genomes through the deamination of cytosine to form uracil in nascent single-stranded (-)DNA. HIV-1 suppresses APOBEC3 activity through the HIV-1 protein Vif that induces APOBEC3 degradation. Here we compared two common polymorphisms of APOBEC3F. We found that although both polymorphisms have HIV-1 restriction activity, APOBEC3F 108 A/231V can restrict HIV-1 ΔVif up to 4-fold more than APOBEC3F 108 S/231I and is partially protected from Vif-mediated degradation. This resulted from higher levels of steady state expression of APOBEC3F 108 A/231 V. Individuals are commonly heterozygous for the APOBEC3F polymorphisms and these polymorphisms formed in cells, independent of RNA, hetero-oligomers between each other and with APOBEC3G. Hetero-oligomerization with APOBEC3F 108 A/231V resulted in partial stabilization of APOBEC3F 108 S/231I and APOBEC3G in the presence of Vif. These data demonstrate functional outcomes of APOBEC3 polymorphisms and hetero-oligomerization that affect HIV-1 restriction." @default.
- W2901923894 created "2018-11-29" @default.
- W2901923894 creator A5019575748 @default.
- W2901923894 creator A5025285510 @default.
- W2901923894 creator A5054289920 @default.
- W2901923894 creator A5061107241 @default.
- W2901923894 creator A5062062407 @default.
- W2901923894 creator A5063260012 @default.
- W2901923894 date "2019-01-01" @default.
- W2901923894 modified "2023-09-24" @default.
- W2901923894 title "Polymorphisms of the cytidine deaminase APOBEC3F have different HIV-1 restriction efficiencies" @default.
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