FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901954715> ?p ?o ?g. }

• W2901954715 endingPage "59" @default.
• W2901954715 startingPage "52" @default.
• W2901954715 abstract "Objectives. Acinetobacter baumannii is a critical nosocomial pathogen. A. baumannii infections have become a grave challenge due to their ability to develop resistance to different antimicrobial agents. The current study aimed to evaluate the potential synergism and bactericidal activity of a combination of colistin and cotrimoxazole against carbapenem-resistant A. baumannii (CRAB) in a Galleria mellonella model. Methods. Four clinical A. baumannii isolates were biochemically and molecularly identified. Their antimicrobial susceptibility levels were established and the molecular characterization of the carbapenemase-encoding genes was performed. The synergism and bactericidal effect of the colistin/cotrimoxazole combination was assessed using the checkerboard assay and time–kill experiments. An in vivo evaluation of the activity of the combination was performed using the Galleria mellonella model. Results. A fractional inhibitory concentration index (FICI) of ≤0.5 was found for all strains, indicating that the colistin/cotrimoxazole combination exhibited powerful synergistic activity. The combination displayed both synergistic and bactericidal activity at sub-breakpoint concentrations for all strains. Cotrimoxazole monotherapy showed the least protective activity in the G. mellonella model. The survival rate ranged from 66.7–79.2 % at 24 h and was 29.2–60.4 % at 96 h for the tested isolates. Colistin monotherapy performed better than cotrimoxazole monotherapy; the G. mellonella survival rate ranged from 77.1–97.9 %, at 24 h and from 64.5–72. % at 96 h. The colistin/cotrimoxazole combination improved G. mellonella’s survival rate at 96 h remarkably in comparison to colistin or cotrimoxazole monotherapy. Conclusions. Finally, the combination of colistin and cotrimoxazole appears to be a promising therapeutic option for the management of CRAB-associated infections. It is essential to assess the clinical application and the dose–response relationships of combinations such as colistin plus cotrimoxazole." @default.
• W2901954715 created "2018-11-29" @default.
• W2901954715 creator A5002570163 @default.
• W2901954715 creator A5018086130 @default.
• W2901954715 creator A5045897383 @default.
• W2901954715 date "2019-01-01" @default.
• W2901954715 modified "2023-10-14" @default.
• W2901954715 title "In vivo activity of co-trimoxazole combined with colistin against Acinetobacter baumannii producing OXA-23 in a Galleria mellonella model" @default.
• W2901954715 cites W1578686320 @default.
• W2901954715 cites W1904655651 @default.
• W2901954715 cites W1963979843 @default.
• W2901954715 cites W1968052795 @default.
• W2901954715 cites W1984809228 @default.
• W2901954715 cites W1986021215 @default.
• W2901954715 cites W1997495012 @default.
• W2901954715 cites W2019951168 @default.
• W2901954715 cites W2024040601 @default.
• W2901954715 cites W2033705339 @default.
• W2901954715 cites W2047365652 @default.
• W2901954715 cites W2049974378 @default.
• W2901954715 cites W2068362753 @default.
• W2901954715 cites W2081819761 @default.
• W2901954715 cites W2088690349 @default.
• W2901954715 cites W2107994215 @default.
• W2901954715 cites W2108773674 @default.
• W2901954715 cites W2115118328 @default.
• W2901954715 cites W2116567804 @default.
• W2901954715 cites W2120409679 @default.
• W2901954715 cites W2120654979 @default.
• W2901954715 cites W2121097797 @default.
• W2901954715 cites W2129889303 @default.
• W2901954715 cites W2135732696 @default.
• W2901954715 cites W2145952139 @default.
• W2901954715 cites W2149687177 @default.
• W2901954715 cites W2157512160 @default.
• W2901954715 cites W2161069049 @default.
• W2901954715 cites W2167117360 @default.
• W2901954715 cites W2169140164 @default.
• W2901954715 cites W2169646524 @default.
• W2901954715 cites W2169781424 @default.
• W2901954715 cites W2181492369 @default.
• W2901954715 cites W2517965980 @default.
• W2901954715 cites W2612557828 @default.
• W2901954715 cites W2757976894 @default.
• W2901954715 cites W2758734536 @default.
• W2901954715 doi "https://doi.org/10.1099/jmm.0.000872" @default.
• W2901954715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30422109" @default.
• W2901954715 hasPublicationYear "2019" @default.
• W2901954715 type Work @default.
• W2901954715 sameAs 2901954715 @default.
• W2901954715 citedByCount "8" @default.
• W2901954715 countsByYear W29019547152019 @default.
• W2901954715 countsByYear W29019547152020 @default.
• W2901954715 countsByYear W29019547152021 @default.
• W2901954715 countsByYear W29019547152023 @default.
• W2901954715 crossrefType "journal-article" @default.
• W2901954715 hasAuthorship W2901954715A5002570163 @default.
• W2901954715 hasAuthorship W2901954715A5018086130 @default.
• W2901954715 hasAuthorship W2901954715A5045897383 @default.
• W2901954715 hasBestOaLocation W29019547151 @default.
• W2901954715 hasConcept C104317684 @default.
• W2901954715 hasConcept C2776315533 @default.
• W2901954715 hasConcept C2777637488 @default.
• W2901954715 hasConcept C2779032433 @default.
• W2901954715 hasConcept C2779259085 @default.
• W2901954715 hasConcept C4937899 @default.
• W2901954715 hasConcept C523546767 @default.
• W2901954715 hasConcept C54355233 @default.
• W2901954715 hasConcept C55493867 @default.
• W2901954715 hasConcept C60987743 @default.
• W2901954715 hasConcept C71924100 @default.
• W2901954715 hasConcept C86803240 @default.
• W2901954715 hasConcept C89423630 @default.
• W2901954715 hasConceptScore W2901954715C104317684 @default.
• W2901954715 hasConceptScore W2901954715C2776315533 @default.
• W2901954715 hasConceptScore W2901954715C2777637488 @default.
• W2901954715 hasConceptScore W2901954715C2779032433 @default.
• W2901954715 hasConceptScore W2901954715C2779259085 @default.
• W2901954715 hasConceptScore W2901954715C4937899 @default.
• W2901954715 hasConceptScore W2901954715C523546767 @default.
• W2901954715 hasConceptScore W2901954715C54355233 @default.
• W2901954715 hasConceptScore W2901954715C55493867 @default.
• W2901954715 hasConceptScore W2901954715C60987743 @default.
• W2901954715 hasConceptScore W2901954715C71924100 @default.
• W2901954715 hasConceptScore W2901954715C86803240 @default.
• W2901954715 hasConceptScore W2901954715C89423630 @default.
• W2901954715 hasIssue "1" @default.
• W2901954715 hasLocation W29019547151 @default.
• W2901954715 hasLocation W29019547152 @default.
• W2901954715 hasOpenAccess W2901954715 @default.
• W2901954715 hasPrimaryLocation W29019547151 @default.
• W2901954715 hasRelatedWork W1853552926 @default.
• W2901954715 hasRelatedWork W1965083442 @default.
• W2901954715 hasRelatedWork W2038305694 @default.
• W2901954715 hasRelatedWork W2108773674 @default.
• W2901954715 hasRelatedWork W2127371980 @default.
• W2901954715 hasRelatedWork W2140345819 @default.
• W2901954715 hasRelatedWork W2265853700 @default.

• next