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• W2901970435 abstract "<h3>BACKGROUND AND PURPOSE:</h3> The aging HIV-infected (HIV⁺) population has increased vascular comorbidities, including stroke, and increased cognitive deficits compared with the general population. Arterial spin-labeling is a technique to measure cerebral blood flow and is more sensitive than regional volume loss in assessing neurodegenerative diseases and cognitive aging. Previous studies have found global cerebral perfusion abnormalities in the HIV⁺ participants. In this study, we evaluated the specific regional pattern of CBF abnormalities in older HIV⁺ participants using quantitative whole-brain arterial spin-labeling. <h3>MATERIALS AND METHODS:</h3> CBF data from the UCSF HIV Over 60 Cohort and the Alzheimer Disease Neuroimaging Initiative were retrospectively evaluated to identify 19 HIV⁺ older adults, all with plasma viral suppression (including 5 with HIV-associated neurocognitive disorder); 13 healthy, age-matched controls; and 19 participants with early mild cognitive impairment. CBF values were averaged by ROI and compared among the 3 groups using generalized linear models. <h3>RESULTS:</h3> When we accounted for age, education, sex, and vascular risk factors, the HIV⁺ participants demonstrated alterations in regional cerebral perfusion, including hypoperfusion of bilateral temporal, parietal, and occipital brain regions compared with both clinically healthy participants and those with mild cognitive impairment. Arterial spin-labeling showed reasonable test characteristics in distinguishing those with HIV-associated neurocognitive disorder from healthy controls and participants with mild cognitive impairment. <h3>CONCLUSIONS:</h3> This study found specific CBF patterns associated with HIV status despite viral suppression—data that should animate further investigations into the pathobiologic basis of vascular and cognitive abnormalities in HIV-associated neurocognitive disorders." @default.
• W2901970435 created "2018-11-29" @default.
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• W2901970435 date "2018-11-22" @default.
• W2901970435 modified "2023-09-27" @default.
• W2901970435 title "Abnormal Cerebral Perfusion Profile in Older Adults with HIV-Associated Neurocognitive Disorder: Discriminative Power of Arterial Spin-Labeling" @default.
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• W2901970435 doi "https://doi.org/10.3174/ajnr.a5902" @default.
• W2901970435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6748330" @default.
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