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• W2901973368 abstract "Abstract Cardiovascular ischemic disease is a large class of diseases that are harmful to human health. The significant role of microRNAs (miRNAs) in terms of controlling cardiac injury has been reported in latest studies. MiR‐98 is very important in regulating the apoptosis, the differentiation, the growth as well as the metastasis of cells. Nevertheless, the effect of miR‐98 in the cardiac ischemia reperfusion (I/R) injury has rarely been investigated. In the current research, we found that the miR‐98 expression was down‐regulated in the cardiomyocytes subjected to hypoxia/reoxygenation (H/R) and in the myocardium of the I/R rats. In addition, over‐expression of miR‐98 could significantly reduce the myocardial oxidative stress and ischemic injury as well as cell apoptosis. In agreement, similar findings were demonstrated in H9c2 cells subjected to H/R injury. Bioinformatic analysis using MiRanda and TargetScan and luciferase activity assay confirmed death‐associated protein kinase 1 (DAPK1) as a direct target of miR‐98. These findings suggest that miR‐98 may be exploited as a novel molecular marker or therapeutic target for myocardial I/R injury. © 2018 IUBMB Life, 71(1):166–176, 2019" @default.
• W2901973368 created "2018-11-29" @default.
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• W2901973368 date "2018-11-12" @default.
• W2901973368 modified "2023-09-26" @default.
• W2901973368 title "MicroRNA-98 attenuates cardiac ischemia-reperfusion injury through inhibiting DAPK1 expression" @default.
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• W2901973368 doi "https://doi.org/10.1002/iub.1879" @default.
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