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- W2901984002 abstract "BiochemistryProteins that emerge from a ribosome bear the N-terminal methionine (Met) residue. In bacteria, Met is formylated before translation starts, whereas in eukaryotes, most nascent proteins seemed to start with unmodified Met. Working in yeast, Kim et al. found that the N-terminal formylation of eukaryotic proteins is detectable even under normal conditions and is greatly increased upon specific stresses, which cause some Fmt1 formyltransferase to be retained in the cytoplasm. The retention of this normally mitochondrial protein was found to require the Gcn2 kinase. In addition, the Psh1 ubiquitin ligase was shown to target N-terminally formylated eukaryotic proteins for proteasome-dependent degradation by the so-called fMet/N-end rule pathway.Science , this issue p. [eaat0174][1] [1]: /lookup/doi/10.1126/science.aat0174" @default.
- W2901984002 created "2018-12-11" @default.
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- W2901984002 date "2018-11-29" @default.
- W2901984002 modified "2023-09-26" @default.
- W2901984002 title "Another N-end rule to add" @default.
- W2901984002 doi "https://doi.org/10.1126/science.362.6418.1014-k" @default.
- W2901984002 hasPublicationYear "2018" @default.
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