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• W2902019944 abstract "This study investigated serum interleukin-10 (IL-10) levels, changes in peripheral blood CD4+CD25+ regulatory T cell (PBCDT) ratios, and the prognosis of cervical cancer (CC) patients.Seventy patients with CC composed the observation group, and 70 healthy subjects composed the control group. The PBCDT ratios in the CC patients and healthy subjects were calculated. Serum IL-10 levels were detected with a double antibody sandwich enzyme-linked immunosorbent assay (ELISA).The PBCDT ratio was higher in the patients with active CC [12.16±2.41%] than in the control subjects [6.34±1.05%]. Serum IL-10 levels were higher in the patients with CC [384±106 pg/ml] than in the control subjects [104±50 pg/ml]; the differences in both PBCDT ratio and IL-10 level were statistically significant (p<0.01). Serum IL-10 levels were positively correlated with PBCDT ratios (r=0.375, p<0.05). The 5-year patient survival rate was significantly higher in the low serum IL-10 group (64.2%) than in the high serum IL-10 group (42.8%, p=0.012).PBCDT ratios and serum IL-10 levels are related to CC activity. These factors are reciprocally related and influence one another, and both are involved in the development and progression of CC. Low IL-10 expression is beneficial regarding the survival of patients with CC." @default.
• W2902019944 created "2018-12-11" @default.
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• W2902019944 date "2018-01-01" @default.
• W2902019944 modified "2023-10-16" @default.
• W2902019944 title "Relationships of interleukin-10 with the regulatory T cell ratio and prognosis of cervical cancer patients" @default.
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• W2902019944 doi "https://doi.org/10.6061/clinics/2018/e679" @default.
• W2902019944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6251251" @default.
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