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- W2902028897 abstract "SUMMARY One of the earliest and most significant events in embryonic development is zygotic genome activation (ZGA). In several species, bulk transcription begins at the mid-blastula transition (MBT) when, after a certain number of cleavages, the embryo attains a particular nuclear-to-cytoplasmic (N/C) ratio, maternal repressors become sufficiently diluted, and the cell cycle slows down. Here we resolve the frog ZGA in time and space by profiling RNA polymerase II (RNAPII) engagement and its transcriptional readout. We detect a gradual increase in both the quantity and the length of RNAPII elongation before the MBT, revealing that >1,000 zygotic genes disregard the N/C timer for their activation, and that the sizes of newly transcribed genes are not necessarily constrained by cell cycle duration. We also find that Wnt, Nodal and BMP signaling together generate most of the spatio-temporal dynamics of regional ZGA, directing the formation of orthogonal body axes and proportionate germ layers." @default.
- W2902028897 created "2018-12-11" @default.
- W2902028897 creator A5044204439 @default.
- W2902028897 creator A5044946533 @default.
- W2902028897 creator A5060587596 @default.
- W2902028897 date "2018-12-06" @default.
- W2902028897 modified "2023-10-16" @default.
- W2902028897 title "The Spatio-Temporal Control of Zygotic Genome Activation" @default.
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