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- W2902034246 abstract "Characterizing changes to structure and behavior is an important aspect of therapeutic protein development. NMR spectroscopy is well suited to study interactions and higher-order structure that could impact biological function and safety. We used NMR diffusion methods to describe the overall behavior of proteins in solution by defining a diffusion profile that captures the complexities in diffusion behavior. Diffusion profiles offer a simple means to interpret protein solution behavior as a distribution of sizes and association states. As a characterization method, diffusion profiling is well suited to complement and augment traditional biophysical and NMR methods to probe the solution behavior of therapeutic proteins." @default.
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- W2902034246 date "2019-03-04" @default.
- W2902034246 modified "2023-09-29" @default.
- W2902034246 title "Diffusion Profiling of Therapeutic Proteins by Using Solution NMR Spectroscopy" @default.
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- W2902034246 doi "https://doi.org/10.1002/cbic.201800631" @default.
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