FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902045785> ?p ?o ?g. }

• W2902045785 endingPage "e0006839" @default.
• W2902045785 startingPage "e0006839" @default.
• W2902045785 abstract "The pathogenesis of Salmonella enterica serovar Typhi (S. Typhi), the cause of typhoid fever in humans, is mainly attributed to the acquisition of horizontally acquired DNA elements. Salmonella pathogenicity islands (SPIs) are indubitably the most important form of horizontally acquired DNA with respect to pathogenesis of this bacterium. The insertion or deletion of any of these transferrable SPIs may have impact on the virulence potential of S. Typhi. In this study, the virulence potential and genetic relatedness of 35 S. Typhi isolates, collected from 2004 to 2013 was determined by identification of SPI and non-SPI virulence factors through a combination of techniques including virulotyping, Whole Genome Sequencing (WGS), and Variable Number of Tandem Repeats (VNTR) profiling. In order to determine the virulence potential of local S. Typhi isolates, 56 virulence related genes were studied by PCR. These genes are located in the core as well as accessory genome (SPIs and plasmid). Major variations among studied virulence determinants were found in case of SPI-7 and SPI-10 associated genes. On the basis of presence of virulence related genes, the studied S. Typhi isolates from Pakistan were clustered into two virulotypes Vi-positive and Vi-negative. Interestingly, SPI-7 and SPI-10 were collectively absent or present in Vi-negative and Vi-positive strains, respectively. Two Vi-negative and 11 Vi-positive S. Typhi strains were also analyzed by whole genome sequencing (WGS) and their results supported the PCR results. Genetic diversity was tested by VNTR-based molecular typing. All 35 isolates were clustered into five groups. Overall, all Vi-negative isolates were placed in a single group (T5) whereas Vi-positive isolates were grouped into four types. Vi-negative and Vi-positive isolates were mutually exclusive. This is the first report on the comparative distribution of SPI and non-SPI related virulence genes in Vi-negative and Vi-positive S. Typhi isolates with an important finding that SPI-10 is absent in all Vi-negative isolates." @default.
• W2902045785 created "2018-12-11" @default.
• W2902045785 creator A5005731285 @default.
• W2902045785 creator A5009261679 @default.
• W2902045785 creator A5014111892 @default.
• W2902045785 creator A5030196621 @default.
• W2902045785 creator A5045734191 @default.
• W2902045785 creator A5060868317 @default.
• W2902045785 creator A5074911591 @default.
• W2902045785 creator A5076486818 @default.
• W2902045785 creator A5084426405 @default.
• W2902045785 date "2018-11-30" @default.
• W2902045785 modified "2023-10-15" @default.
• W2902045785 title "Virulotyping of Salmonella enterica serovar Typhi isolates from Pakistan: Absence of complete SPI-10 in Vi negative isolates" @default.
• W2902045785 cites W1511623148 @default.
• W2902045785 cites W1552488505 @default.
• W2902045785 cites W161134795 @default.
• W2902045785 cites W1911152711 @default.
• W2902045785 cites W1921367924 @default.
• W2902045785 cites W1965958252 @default.
• W2902045785 cites W1968846062 @default.
• W2902045785 cites W1978486201 @default.
• W2902045785 cites W1981104210 @default.
• W2902045785 cites W1985942985 @default.
• W2902045785 cites W1996954693 @default.
• W2902045785 cites W1999045045 @default.
• W2902045785 cites W2001914179 @default.
• W2902045785 cites W2003602243 @default.
• W2902045785 cites W2005546292 @default.
• W2902045785 cites W2009703894 @default.
• W2902045785 cites W2019849270 @default.
• W2902045785 cites W2023911006 @default.
• W2902045785 cites W2026067686 @default.
• W2902045785 cites W2034223856 @default.
• W2902045785 cites W2034730497 @default.
• W2902045785 cites W2038065826 @default.
• W2902045785 cites W2038662968 @default.
• W2902045785 cites W2043812664 @default.
• W2902045785 cites W2049825741 @default.
• W2902045785 cites W2055043387 @default.
• W2902045785 cites W2055862784 @default.
• W2902045785 cites W2064683530 @default.
• W2902045785 cites W2068317605 @default.
• W2902045785 cites W2078958177 @default.
• W2902045785 cites W2086283512 @default.
• W2902045785 cites W2090913604 @default.
• W2902045785 cites W2092433222 @default.
• W2902045785 cites W2095086636 @default.
• W2902045785 cites W2098703499 @default.
• W2902045785 cites W2100792876 @default.
• W2902045785 cites W2102898060 @default.
• W2902045785 cites W2109169305 @default.
• W2902045785 cites W2110397906 @default.
• W2902045785 cites W2112814753 @default.
• W2902045785 cites W2114087442 @default.
• W2902045785 cites W2114427446 @default.
• W2902045785 cites W2114751628 @default.
• W2902045785 cites W2121467305 @default.
• W2902045785 cites W2121981448 @default.
• W2902045785 cites W2122170012 @default.
• W2902045785 cites W2122799649 @default.
• W2902045785 cites W2123269578 @default.
• W2902045785 cites W2124234780 @default.
• W2902045785 cites W2130527200 @default.
• W2902045785 cites W2133237540 @default.
• W2902045785 cites W2134678725 @default.
• W2902045785 cites W2135146244 @default.
• W2902045785 cites W2136369541 @default.
• W2902045785 cites W2137678717 @default.
• W2902045785 cites W2139790819 @default.
• W2902045785 cites W2140748993 @default.
• W2902045785 cites W2142330755 @default.
• W2902045785 cites W2143150258 @default.
• W2902045785 cites W2143396255 @default.
• W2902045785 cites W2143750684 @default.
• W2902045785 cites W2146341019 @default.
• W2902045785 cites W2148289442 @default.
• W2902045785 cites W2157738884 @default.
• W2902045785 cites W2158804744 @default.
• W2902045785 cites W2162842304 @default.
• W2902045785 cites W2165645605 @default.
• W2902045785 cites W2166419732 @default.
• W2902045785 cites W2186611612 @default.
• W2902045785 cites W2315106853 @default.
• W2902045785 cites W2788800189 @default.
• W2902045785 cites W4251041657 @default.
• W2902045785 cites W4254002014 @default.
• W2902045785 doi "https://doi.org/10.1371/journal.pntd.0006839" @default.
• W2902045785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6267989" @default.
• W2902045785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30500817" @default.
• W2902045785 hasPublicationYear "2018" @default.
• W2902045785 type Work @default.
• W2902045785 sameAs 2902045785 @default.
• W2902045785 citedByCount "12" @default.
• W2902045785 countsByYear W29020457852020 @default.
• W2902045785 countsByYear W29020457852021 @default.
• W2902045785 countsByYear W29020457852022 @default.
• W2902045785 countsByYear W29020457852023 @default.

• next