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• W2902046275 endingPage "13122" @default.
• W2902046275 startingPage "13117" @default.
• W2902046275 abstract "Significance Proteins embedded in the cell membrane are subjected to the membrane’s chemical and physical modifications. Here, we report that cholesterol and other sterols attenuated single-channel activities of a prototypical potassium channel KcsA. Inherent lipid bilayer tension was measured high compared with cell membrane tension, and all tested sterols decreased bilayer tension. Reducing tension by mechanical means also attenuated channel activity. Thus, channel activity was regulated by bilayer tension changes under chemical and physical perturbations. Unlike conventional stretch activation, bilayer tension activated the channel only when the channel was stimulated by intracellular acidic pH. Overall, acidic pH is necessary for activation, but channel opening is fine-tuned by membrane tension in what constitutes a doubly regulated activation modality." @default.
• W2902046275 created "2018-12-11" @default.
• W2902046275 creator A5023979356 @default.
• W2902046275 creator A5033998713 @default.
• W2902046275 date "2018-12-03" @default.
• W2902046275 modified "2023-09-23" @default.
• W2902046275 title "Constitutive boost of a K ⁺ channel via inherent bilayer tension and a unique tension-dependent modality" @default.
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• W2902046275 doi "https://doi.org/10.1073/pnas.1812282115" @default.
• W2902046275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6304998" @default.
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• W2902046275 hasPublicationYear "2018" @default.
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