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• W2902078215 endingPage "515" @default.
• W2902078215 startingPage "515" @default.
• W2902078215 abstract "Toxin-antitoxin (TA) systems are known to play various roles in physiological processes, such as gene regulation, growth arrest and survival, in bacteria exposed to environmental stress. Type II TA systems comprise natural complexes consisting of protein toxins and antitoxins. Each toxin and antitoxin participates in distinct regulatory mechanisms depending on the type of TA system. Recently, peptides designed by mimicking the interfaces between TA complexes showed its potential to activate the activity of toxin by competing its binding counterparts. Type II TA systems occur more often in pathogenic bacteria than in their nonpathogenic kin. Therefore, they can be possible drug targets, because of their high abundance in some pathogenic bacteria, such as Mycobacterium tuberculosis. In addition, recent bioinformatic analyses have shown that type III TA systems are highly abundant in the intestinal microbiota, and recent clinical studies have shown that the intestinal microbiota is linked to inflammatory diseases, obesity and even several types of cancer. We therefore focused on exploring the putative relationship between intestinal microbiota-related human diseases and type III TA systems. In this paper, we review and discuss the development of possible druggable materials based on the mechanism of type II and type III TA system." @default.
• W2902078215 created "2018-12-11" @default.
• W2902078215 creator A5031280773 @default.
• W2902078215 creator A5056442022 @default.
• W2902078215 creator A5076845979 @default.
• W2902078215 creator A5086369397 @default.
• W2902078215 date "2018-12-04" @default.
• W2902078215 modified "2023-10-17" @default.
• W2902078215 title "A Systematic Overview of Type II and III Toxin-Antitoxin Systems with a Focus on Druggability" @default.
• W2902078215 cites W1483017980 @default.
• W2902078215 cites W1499916435 @default.
• W2902078215 cites W1510613202 @default.
• W2902078215 cites W1519094768 @default.
• W2902078215 cites W1561866161 @default.
• W2902078215 cites W1764746526 @default.
• W2902078215 cites W1798817938 @default.
• W2902078215 cites W1820567505 @default.
• W2902078215 cites W1893619344 @default.
• W2902078215 cites W1902150932 @default.
• W2902078215 cites W1951116384 @default.
• W2902078215 cites W1964968781 @default.
• W2902078215 cites W1967691135 @default.
• W2902078215 cites W1968305507 @default.
• W2902078215 cites W1970743383 @default.
• W2902078215 cites W1974053222 @default.
• W2902078215 cites W1977293483 @default.
• W2902078215 cites W1982583457 @default.
• W2902078215 cites W1982958351 @default.
• W2902078215 cites W1983770726 @default.
• W2902078215 cites W1984774221 @default.
• W2902078215 cites W1987348801 @default.
• W2902078215 cites W1988490582 @default.
• W2902078215 cites W1989802059 @default.
• W2902078215 cites W2001420097 @default.
• W2902078215 cites W2001582257 @default.
• W2902078215 cites W2003324857 @default.
• W2902078215 cites W2005593489 @default.
• W2902078215 cites W2007887595 @default.
• W2902078215 cites W2009170813 @default.
• W2902078215 cites W2016912614 @default.
• W2902078215 cites W2017145164 @default.
• W2902078215 cites W2019197162 @default.
• W2902078215 cites W2021350676 @default.
• W2902078215 cites W2023985059 @default.
• W2902078215 cites W2024601462 @default.
• W2902078215 cites W2025065287 @default.
• W2902078215 cites W2027085730 @default.
• W2902078215 cites W2027708118 @default.
• W2902078215 cites W2032782331 @default.
• W2902078215 cites W2036577985 @default.
• W2902078215 cites W2039815032 @default.
• W2902078215 cites W2041350348 @default.
• W2902078215 cites W2042478438 @default.
• W2902078215 cites W2042777786 @default.
• W2902078215 cites W2044079597 @default.
• W2902078215 cites W2047158803 @default.
• W2902078215 cites W2047444863 @default.
• W2902078215 cites W2047627447 @default.
• W2902078215 cites W2047628885 @default.
• W2902078215 cites W2048294297 @default.
• W2902078215 cites W2051584259 @default.
• W2902078215 cites W2052554412 @default.
• W2902078215 cites W2059193979 @default.
• W2902078215 cites W2066845647 @default.
• W2902078215 cites W2070190014 @default.
• W2902078215 cites W2073332363 @default.
• W2902078215 cites W2076554517 @default.
• W2902078215 cites W2078536451 @default.
• W2902078215 cites W2080700521 @default.
• W2902078215 cites W2084672467 @default.
• W2902078215 cites W2085646557 @default.
• W2902078215 cites W2088363828 @default.
• W2902078215 cites W2089289014 @default.
• W2902078215 cites W2090022879 @default.
• W2902078215 cites W2090925778 @default.
• W2902078215 cites W2091426267 @default.
• W2902078215 cites W2091883313 @default.
• W2902078215 cites W2095012297 @default.
• W2902078215 cites W2095854550 @default.
• W2902078215 cites W2103222799 @default.
• W2902078215 cites W2103928969 @default.
• W2902078215 cites W2105932261 @default.
• W2902078215 cites W2106225552 @default.
• W2902078215 cites W2106661192 @default.
• W2902078215 cites W2106829739 @default.
• W2902078215 cites W2107097628 @default.
• W2902078215 cites W2109560282 @default.
• W2902078215 cites W2111555302 @default.
• W2902078215 cites W2114257996 @default.
• W2902078215 cites W2115463917 @default.
• W2902078215 cites W2119853807 @default.
• W2902078215 cites W2120495574 @default.
• W2902078215 cites W2121797177 @default.
• W2902078215 cites W2122492159 @default.
• W2902078215 cites W2124030991 @default.
• W2902078215 cites W2124424637 @default.
• W2902078215 cites W2125730783 @default.
• W2902078215 cites W2126573196 @default.

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